One Pot Bio-Synthesis of Palladium Nanoneedles and Its Bioavailability

Abstract

Bioinorganic chemistry has achieved great importance by considering environmental and health issues. Here we present anticancer, antioxidant, good protein quencher single pot biosynthesized one dimensional palladium Nanoneedles (PdNNs) as a negative catalyst, where water plays a role of safer solvent. Needle-shaped one-dimensional PdNNs was synthesized using filamentous fungal stain of Aspergillus oryzae (biomass) was successively applied as a suppressant for the growth of human breast, colon and leukemia cancer Cell Lines. Quenching process of bovine serum albumin by PdNNs was spontaneous with hydrogen bonding and hydrophilic interaction. Interaction of protein and PdNNs showed binding constant in the range of 104 M-1 and one binding site. Forster's resonance energy transfer (FRET) theory applied to find out distance between the interaction of PdNNs and protein, where critical distance and energy transfer distance varies with change in concentrations of PdNNs 4.84 x 10−6 M to 9.69 x 10-7 M from 2.9 to 3.7 nm and 3.2 to 5.4 nm respectively. Radical scavenging method was applied to find out an antioxidant activity which of nanoneedles. Needle-shaped palladium nanoparticles and particle size found to be ̴ 3.0 nm using high-resolution transmission electron microscopes.