One Pot and Two Pot Synthetic Strategies and Biological Applications of Epoxy-Chalcones

Abstract

Epoxy chalcone is a heterocyclic molecule and an important precursor for the synthesis of biologically active compounds. This mini-review is elucidating the synthetic strategies of chalcone epoxide via one pot and two pot routes including nature of reactants, nature of catalyst and variety of catalyst to improve yield of desired product, biological applications and advantages and drawbacks of these synthetic strategies. One pot route has wide variety of reactants and efficient one is the condensation of aldehyde and ketone. However, two pot route is consisted of chalcone synthesis preceding to epoxy chalcone. The synthetic routes for the preparation of epoxy chalcone and the usage as a precursor for the synthesis of various organic molecules with biological application is comprehensively discussed. This review is outstanding in organic chemistry and pharmaceutical industries to produce new molecules with various applications. Graphic AbstractO O

Microwave‐Assisted Synthesis, Antimicrobial Activities and Molecular Docking of Methoxycarboxylated Chalcone Derived Pyrazoline and Pyrazole Derivatives

“…The heterocyclic compounds derived from chalcones are valuable in pharmaceutical industries [7] . Chalcone derivatives disclosed the fascinating properties of heterocyclic pyrazoline due to its stability and aromatic properties, [8] which is a significant aspect of a wide range of biological activities [9] . Pyrazoline is pharmacologically active compounds with excellent antifungal, [10] hypoglycaemic, [11] antioxidant, [12] antibacterial, [13] anticancer, [14] antipyretic, [15] antimalarial, [16] antitubercular [17,18] properties.…”

Synthesis and a Catalytic Study of Diastereomeric Cationic Chiral-at-Cobalt Complexes Based on (R,R)-1,2-Diphenylethylenediamine

“…However, although many efficient catalysts are known for the kinetic resolution of racemic monosubstituted epoxides, − the resolution of disubstituted epoxides poses significant challenges . To best of our knowledge, only one example of the kinetic resolution of disubstituted epoxides with CO 2 has been reported .…”

One‐potandtwo‐potmethods for chalcone derived pyrimidines synthesis and applications

“…[151] Herein, we discuss comprehensive synthetic methods via one-pot and two-pot for the synthesis of pyrimidine derivatives from chalcone, a highly stable, cheap, commercially available starting material. Chalcone [152,153] is a common and excellent precursor employed in the synthesis of heterocycles (i.e., pyrazole, pyrazoline, [154][155][156] flavone, [157] cyclohexenone, [158] epoxide, [159] and pyrimidine [160,161] ). The review is a benefit to organic chemist researchers to design more potent unique compounds for pharmaceutical industries.…”