One-pot amide synthesis from allyl or benzyl halides and amines by Pd-catalysed carbonylation

Air‐stable Bis(pentamethylcyclopentadienyl) Zirconium Perfluorooctanesulfonate as an Efficient and Recyclable Catalyst for the Synthesis of N‐substituted Amides

“…More recently, transition metal catalyzed oxidative amidation of alcohols or aldehydes with amines has been developed for amides synthesis (path b, c) . Alternative approaches including the carbonylation of alkyl or benzyl halides with amines (path d),, the reaction of substituted alkynyl bromides with amines (path e), the amidation of carboxylic acids with tert ‐amines through C−N bond cleavage (path f), and the oxidative coupling of carboxylic acids with formamides (path g) have been introduced. However, many of these approaches are problematic regarding cost and atom‐efficiency, as well as functional group tolerance and recyclability.…”

Palladium‐Catalyzed Aminocarbonylation of Allylic Alcohols

“…Compared to the direct functionalization of allylic alcohols, the palladium-catalyzed carbonylation of activated allylic compounds such as allyl halides, [9] allyl carbonates, [10] phosphonates, [11] and carbamates [12] have been known since the 1990s.…”

Direct Amidation of Carboxylic Acids with Tertiary Amines: Amide Formation over Copper Catalysts through C–N Bond Cleavage

“…Later in 1979, Grieco et al disclosed the direct conversion of carboxylic acids into amides by using primary or secondary amines as starting materials (Scheme , path b) 2b. In 2010, Troisi et al published the one‐pot synthesis of amides over a palladium catalyst through the carbonylation of alkyl or benzyl halides with amines (Scheme , path c) 2c. Later, Chen et al2d and Rieke and Kim2e demonstrated the preparation of amides by using substituted alkynyl bromides and organozinc reagents as starting materials (Scheme , paths d and e).…”