One of the Korean mistletoe species, Loranthus yadoriki Sieb. exhibited potent inhibitory activities against monoamine oxidases

Hwang, Keum-Hee; Kim, J; Choi, Yun-Sik; Choj, K; Park, K

doi:10.1055/s-0031-1282451

Cited by 4 publications

(2 citation statements)

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“…Five species of mistletoe are widely distributed in the Republic of Korea. Viscum album L., known as European mistletoe, and Loranthus parasiticus , known as Mulberry mistletoe, are mainly used for traditional medicine in the Republic of Korea [ 2 ]. Mistletoe possesses various beneficial effects, such as anticancer, antiobesity, neuroprotection, antioxidant, and anti-inflammation activities [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect ofLoranthus parasiticuson IgE-Mediated Allergic Responses in RBL-2H3 Cells

Yoo

Yang

Kim

et al. 2016

Mediators of Inflammation

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The mistletoe Loranthus parasiticus has been used as a compound for traditional medicine in Northeast Asia for a long time and is known to possess neuroprotective action. Nonetheless, the effect of Loranthus parasiticus on allergic responses remains unknown. In the present study, we evaluated whether the water extract of Loranthus parasiticus (LPE) could inhibit IgE-mediated allergic responses in RBL-2H3 cells. LPE inhibited the release of β-hexosaminidase (IC50, 184.5 μg/mL) and the formation of tumor necrosis factor-α (IC50, 84.27 μg/mL), interleukin-4 (IC50, 93.43 μg/mL), prostaglandin E2 (IC50, 84.10 μg/mL), prostaglandin D2, and leukotriene C4 (IC50, 43.27 μg/mL) in a concentration-dependent manner. Moreover, LPE inhibited phosphorylation of Syk, PLCγ1/2, PKCδ, ERK, JNK, p38, and Akt. In the late phase, LPE decreased 5-lipoxygenase phosphorylation and COX-2 expression but not cPLA2 phosphorylation. Additionally, LPE included total phenolic compounds (10.72 mg/g dry weight) and total flavonoids (56.20 mg/g dry weight). These results suggest that the phenolic compounds or flavonoids contained in LPE may be associated with antiallergic activity. The phenolic compounds and flavonoids in LPE are antiallergic phytochemicals capable of inhibiting the activation of the FcεRI signaling cascade in mast cells. Such effects may provide further information for the development of a phytomedicine for allergic diseases.

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Section: Introductionmentioning

confidence: 99%

Inhibitory Effect ofLoranthus parasiticuson IgE-Mediated Allergic Responses in RBL-2H3 Cells

Yoo

Yang

Kim

et al. 2016

Mediators of Inflammation

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show abstract

“…Mistletoe is a semi-parasitic plant that possesses various beneficial effects such as anticancer, anti-inflammation, anti-obesity, antioxidant, and neuroprotection [ 7 ]. Viscum coloratum , known as Korean mistletoe, and Loranthus parasiticus , known as Mulberry mistletoe, have long been used as part of traditional medicine in Northeast Asia [ 8 ]. Extract of Viscum album L., known as European mistletoe, has been used as an anticancer therapy in Europe because lectins, carbohydrate-binding proteins, viscotoxins, and small phytoproteins in Viscum album L. possess strong anticancer activity [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Viscum coloratum Extract on IgE/Antigen-Activated Mast Cells and Mast Cell-Derived Inflammatory Mediator-Activated Chondrocytes

et al. 2016

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The accumulation and infiltration of mast cells are found in osteoarthritic lesions in humans and rodents. Nonetheless, the roles of mast cells in osteoarthritis are almost unknown. Although Viscum coloratum has various beneficial actions, its effect on allergic and osteoarthritic responses is unknown. In this study, we established an in vitro model of mast cell-mediated osteoarthritis and investigated the effect of the ethanol extract of Viscum coloratum (VEE) on IgE/antigen (IgE/Ag)-activated mast cells and mast cell-derived inflammatory mediator (MDIM)-stimulated chondrocytes. The anti-allergic effect of VEE was evaluated by degranulation, inflammatory mediators, and the FcεRI signaling cascade in IgE/Ag-activated RBL-2H3 cells. The anti-osteoarthritic action of VEE was evaluated by cell migration, and the expression, secretion, and activity of MMPs in MDIM-stimulated SW1353 cells. VEE significantly inhibited degranulation (IC50: 93.04 μg/mL), the production of IL-4 (IC50: 73.28 μg/mL), TNF-α (IC50: 50.59 μg/mL), PGD2 and LTC4, and activation of the FcεRI signaling cascade in IgE/Ag-activated RBL-2H3 cells. Moreover, VEE not only reduced cell migration but also inhibited the expression, secretion, and/or activity of MMP-1, MMP-3, or MMP-13 in MDIM-stimulated SW1353 cells. In conclusion, VEE possesses both anti-allergic and anti-osteoarthritic properties. Therefore, VEE could possibly be considered a new herbal drug for anti-allergic and anti-osteoarthritic therapy. Moreover, the in vitro model may be useful for the development of anti-osteoarthritic drugs.

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Induction of Apoptotic Cell Death on Human Cervix Cancer HeLa cells by Extract from Loranthus yadoriki

Kim

Kang

Kim

et al. 2018

Biotechnol Bioproc E

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One of the Korean mistletoe species, Loranthus yadoriki Sieb. exhibited potent inhibitory activities against monoamine oxidases

Cited by 4 publications

References 0 publications

Inhibitory Effect ofLoranthus parasiticuson IgE-Mediated Allergic Responses in RBL-2H3 Cells

Inhibitory Effect ofLoranthus parasiticuson IgE-Mediated Allergic Responses in RBL-2H3 Cells

Inhibitory Effects of Viscum coloratum Extract on IgE/Antigen-Activated Mast Cells and Mast Cell-Derived Inflammatory Mediator-Activated Chondrocytes

Induction of Apoptotic Cell Death on Human Cervix Cancer HeLa cells by Extract from Loranthus yadoriki

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