One night on-call: Sleep deprivation affects cardiac autonomic control and inflammation in physicians

Tobaldini, Eleonora; Cogliati, Chiara; Fiorelli, Elisa Maria; Nunziata, Vanessa; Wu, Maddalena Alessandra; Prado, Marta; Bevilacqua, Maurizio; Trabattoni, Daria; Porta, Alberto; Montano, Nicola

doi:10.1016/j.ejim.2013.03.011

Cited by 99 publications

(74 citation statements)

References 42 publications

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“…In addition, there is evidence that acute sleep deprivation reduces the amplitude of both sympathetic and parasympathetic responses at HUTT in healthy subjects [37], similar to what has been observed in our sample. Therefore we cannot rule out that sleep disturbances associated with RLS (insomnia, poor sleep efficiency), rather than the disease itself, are responsible for lower reactivity of the autonomic system during orthostatic stress.…”

Section: Tablesupporting

confidence: 76%

Is autonomic nervous system involved in restless legs syndrome during wakefulness?

et al. 2014

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A B S T R A C TObjective: To investigate cardiovascular autonomic function in patients with restless leg syndrome (RLS) by means of cardiovascular reflexes and heart rate variability (HRV) during wakefulness. Methods: Twelve RLS patients and 14 controls underwent cardiovascular function tests including headup tilt test (HUTT), Valsalva maneuver, deep breathing, hand grip, and cold face. HRV analysis was performed in the frequency domain using both autoregressive (AR) and fast Fourier transform algorithms in rest supine condition and during HUTT.Results: There was a significant increase in systolic blood pressure values in supine rest condition and a trend toward a lower Valsalva ratio in RLS patients with respect to controls. The significant and physiological changes of HRV at HUTT detected in healthy subjects were not found in RLS patients. Conclusion: RLS patients exhibit a tendency toward hypertension, reduced amplitude of both sympathetic and parasympathetic responses at HUTT, as well as blunted parasympathetic drive to blood pressure changes. These findings, if confirmed by more controlled studies, might support the hypothesis of autonomic nervous system involvement during wakefulness and consequently an enhanced cardiovascular risk in RLS.

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Section: Tablesupporting

confidence: 76%

Is autonomic nervous system involved in restless legs syndrome during wakefulness?

et al. 2014

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“…One of the possible mechanisms is the alterations in cardiac autonomic regulation. In a recently published article, Tobaldini and friends analyzed the effects of SD in autonomic regulatory response indices by applying the head-up tilt test (HUT) in 15 internal medicine residents, and they found dominant sympathetic modulation besides withdrawal in parasympathetic modulation with SD [8].…”

Section: Discussionmentioning

confidence: 99%

“…Although cardiovascular effects of sleep deprivation (SD) have been demonstrated in several studies, underlying pathophysiological mechanism has not been clearly demonstrated [3][4][5][6][7]. Autonomic nervous system plays a major role in the regulation of cardiovascular function, and the effect of sleep deprivation on cardiovascular autonomic response is not clear [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Effect of acute sleep deprivation on heart rate recovery in healthy young adults

et al. 2014

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“…Despite studies showing the impact of sleep debt on cardiovascular health, 4,12 little is known about its effects on cardiac contractile machinery and the role of resistance training as a preventive tool. Therefore, the aim of this study was to evaluate the effect of high-intensity resistance training on myocardial contractility in rats subsequently subjected to paradoxical sleep deprivation.…”

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confidence: 99%

Effect Of Resistance Training On Myocardial Contractility In Vitro After Sleep Deprivation

Giampá

Mônico‐Neto

Souza

et al. 2017

International Journal of Cardiovascular Sciences

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Background: Resistance training promotes cardiovascular health benefits that may affected by sleep deprivation. Objective:To evaluate the effect of high-intensity resistance training on myocardial contractility in rats subsequently subjected to paradoxical sleep deprivation. Methods:Forty male Wistar rats were distributed into control group (CTRL), resistance training (REST), 96-hour paradoxical sleep deprivation (PSD96) and resistance training followed by 96-hour paradoxical sleep deprivation (REST/PSD96). The animals underwent high-intensity resistance training for 8 weeks, 5x/week. Twenty-four hours after the last training session, the PSD96 and REST/PSD96 groups were submitted to paradoxical sleep deprivation, which was followed by the in vitro study of isolated papillary muscle contractile mechanics. Results:In comparison with the CTRL group, a lower papillary muscle length and increased cross sectional area were found in PSD96 and RETS/PSD96, which were associated with decreased temporal parameters of contraction force and relaxation. Decreased resting tension and slowing of relaxation time were found in the PSD96 group only. This effect was attenuated by previous resistance training. Conclusion:Resistance training partially prevented contractile changes induced by PSD, minimizing the slowing in relaxation time. Thus, high-intensity exercise seems to not fully protect the cardiac tissue from PSD-induced effects. (Int J Cardiovasc Sci. 2017;30(1):20-31)

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One night on-call: Sleep deprivation affects cardiac autonomic control and inflammation in physicians

Cited by 99 publications

References 42 publications

Is autonomic nervous system involved in restless legs syndrome during wakefulness?

Is autonomic nervous system involved in restless legs syndrome during wakefulness?

Effect of acute sleep deprivation on heart rate recovery in healthy young adults

Effect Of Resistance Training On Myocardial Contractility In Vitro After Sleep Deprivation

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