‘One medicine—one pathology': are veterinary and human pathology prepared?

Cardiff, Robert D.; Ward, Jerrold M.; Barthold, Stephen W.

doi:10.1038/labinvest.3700695

Cited by 123 publications

(104 citation statements)

References 63 publications

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“…y Mechanistically, molecularly novel GEM phenotypes may justify novel criteria and terminology, but expertise in ''normal'' mouse anatomy and pathology is critical to identify and interpret novel pathology phenotypes. 46,48,109,210 Supplemental Tables S1 and S2 include terminology from the original publications and illustrate some of the evolution of terminology over the past 8 or more decades.…”

Section: Nomenclature Of Mice Genes and Genetic Manipulationsmentioning

confidence: 99%

Pathobiology of Aging Mice and GEM

2012

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The use of induced and spontaneous mutant mice and genetically engineered mice (and combinations thereof) to study cancers and other aging phenotypes to advance improved functional human life spans will involve studies of aging mice. Genetic background contributes to pathology phenotypes and to causes of death as well as to longevity. Increased recognition of expected phenotypes, experimental variables that influence phenotypes and research outcomes, and experimental design options and rationales can maximize the utility of genetically engineered mice (GEM) models to translational research on aging. This review aims to provide resources to enhance the design and practice of chronic and longevity studies involving GEM. C57BL6, 129, and FVB/N strains are emphasized because of their widespread use in the generation of knockout, transgenic, and conditional mutant GEM. Resources are included also for pathology of other inbred strain families, including A, AKR, BALB/c, C3H, C57L, C58, CBA, DBA, GR, NOD.scid, SAMP, and SJL/J, and non-inbred mice, including 4WC, AB6F1, Ames dwarf, B6, 129, B6C3F1, BALB/c,129, Het3, nude, SENCAR, and several Swiss stocks. Experimental strategies for long-term cross-sectional and longitudinal studies to assess causes of or contributors to death, disease burden, spectrum of pathology phenotypes, longevity, and functional healthy life spans (health spans) are compared and discussed.

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Section: Nomenclature Of Mice Genes and Genetic Manipulationsmentioning

confidence: 99%

Pathobiology of Aging Mice and GEM

2012

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“…One Health has been recognized as a major strategy of disease control and prevention by the US Department of Agriculture, US Centers for Disease Control and Prevention (CDC), World Bank, World Health Organization (WHO), Food and Agriculture Organization of the United Nations (FAO), World Organization for Animal Health (OIE), United Nations System Influenza Coordination (UNSIC), European Commission and other entities [5][6][7].…”

Section: Editorialmentioning

confidence: 99%

Zoonotic Diseases and One Health Approach

Dahal¹,

Kahn²

2014

Epidemiol

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“…Now that both the AMA and AVMA have embraced the One Medicine concept, the time is right to reinforce the universality of medicine and further unite veterinary and human medicine. 1 We can do this by adopting a term more familiar and respected by the public. We can elevate the postmortem examination of animals to a process on par with human medicine and perhaps increase the idea of the importance of this to further our understanding of animal disease.…”

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confidence: 99%

Necropsy or Autopsy? It’s All About Communication!

et al. 2011

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Several of us have decided that communication is more important than tradition. Yes, Virginia, we were all drilled in the discipline of veterinary pathology by traditionalists. We're stubborn individualists, aren't we? Greats like John King have necropsied thousands of animals, and we want our procedure to be distinguished from the ''other'' side-the RDs (well okay, the MDs). The short answer is that ''necropsy'' literally means ''death examination'' or examination of death and finds its application in the study of bodies following death. The term is general without reference to species. ''Autopsy'' literally means ''self-examination,'' and some of us were taught that the frame of reference for ''self'' referred to the postmortem examination of ''ourselves'' or our own species, humans. As such, postmortem examination of nonhumans was proscribed from using the term and was designated ''necropsy.'' But hold on there a minute, let's see what Webster has to say. Or as Don Meuten likes to say, ''Show me the reference!''

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‘One medicine—one pathology': are veterinary and human pathology prepared?

Cited by 123 publications

References 63 publications

Pathobiology of Aging Mice and GEM

Pathobiology of Aging Mice and GEM

Zoonotic Diseases and One Health Approach

Necropsy or Autopsy? It’s All About Communication!

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