The Two-Higgs-Doublet model (2HDM) is a simple and viable extension of the Standard Model with a scalar potential complex enough that two minima may coexist. In this work we investigate if the procedure to identify our vacuum as the global minimum by tree-level formulas carries over to the one-loop corrected potential. In the CP conserving case, we identify two distinct types of coexisting minima -the regular ones (moderate tan β) and the non-regular ones (small or large tan β) -and conclude that the tree level expectation fails only for the non-regular type of coexisting minima. For the regular type, the sign of m 2 12 already precisely indicates which minima is the global one, even at one-loop.