One Hundred Patients With Staphylococcus Septicemia Receiving Bacteriophage Service

MacNeal, Ward J.; Frisbee, Frances C.

doi:10.1097/00000441-193602000-00004

Cited by 30 publications

(16 citation statements)

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“…Good efficacy in the treatment was demonstrated by specific phages [77,78] or phage cocktails [79]. Even severe cases of bacteremia and sepsis were reported as treatable with a phage [78,79].…”

Section: Staphylococcal Phages In Medicinementioning

confidence: 99%

Facing Antibiotic Resistance: Staphylococcus aureus Phages as a Medical Tool

Kaźmierczak

Górski

Dąbrowska

2014

Viruses

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Staphylococcus aureus is a common and often virulent pathogen in humans. This bacterium is widespread, being present on the skin and in the nose of healthy people. Staphylococcus aureus can cause infections with severe outcomes ranging from pustules to sepsis and death. The introduction of antibiotics led to a general belief that the problem of bacterial infections would be solved. Nonetheless, pathogens including staphylococci have evolved mechanisms of drug resistance. Among current attempts to address this problem, phage therapy offers a promising alternative to combat staphylococcal infections. Here, we present an overview of current knowledge on staphylococcal infections and bacteriophages able to kill Staphylococcus, including experimental studies and available data on their clinical use.

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Section: Staphylococcal Phages In Medicinementioning

confidence: 99%

Facing Antibiotic Resistance: Staphylococcus aureus Phages as a Medical Tool

Kaźmierczak

Górski

Dąbrowska

2014

Viruses

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“…76 The use of phage treatment for local infections, including particularly those due to Staphylococcus, has the distinction of being one of only two phage therapy strategies that were deemed to be convincingly efficacious by the 1934 Eaton and Bayne-Jones report, [14][15][16] an otherwise phage-therapy skeptical publication; see also reference 77. Indeed, the first human phage therapy publication reported on treatment of S. aureus skin infections.…”

Section: Phage Approaches To Treatment Of Specific Diseasesmentioning

confidence: 99%

Phage treatment of human infections

et al. 2011

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Phages as bactericidal agents have been employed for 90 years as a means of treating bacterial infections in humans as well as other species, a process known as phage therapy. In this review we explore both the early historical and more modern use of phages to treat human infections. We discuss in particular the little-reviewed French early work, along with the Polish, US, Georgian and Russian historical experiences. We also cover other, more modern examples of phage therapy of humans as differentiated in terms of disease. In addition, we provide discussions of phage safety, other aspects of phage therapy pharmacology, and the idea of phage use as probiotics.

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“…SAB mortality rates of between 75% and 83% were observed in the preantibiotic era (182,196). The introduction of antibiotics in the 1940s and 1950s resulted in better outcomes (320).…”

Section: Mortalitymentioning

confidence: 99%

Predictors of Mortality in Staphylococcus aureus Bacteremia

et al. 2012

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SUMMARY Staphylococcus aureus bacteremia (SAB) is an important infection with an incidence rate ranging from 20 to 50 cases/100,000 population per year. Between 10% and 30% of these patients will die from SAB. Comparatively, this accounts for a greater number of deaths than for AIDS, tuberculosis, and viral hepatitis combined. Multiple factors influence outcomes for SAB patients. The most consistent predictor of mortality is age, with older patients being twice as likely to die. Except for the presence of comorbidities, the impacts of other host factors, including gender, ethnicity, socioeconomic status, and immune status, are unclear. Pathogen-host interactions, especially the presence of shock and the source of SAB, are strong predictors of outcomes. Although antibiotic resistance may be associated with increased mortality, questions remain as to whether this reflects pathogen-specific factors or poorer responses to antibiotic therapy, namely, vancomycin. Optimal management relies on starting appropriate antibiotics in a timely fashion, resulting in improved outcomes for certain patient subgroups. The roles of surgery and infectious disease consultations require further study. Although the rate of mortality from SAB is declining, it remains high. Future international collaborative studies are required to tease out the relative contributions of various factors to mortality, which would enable the optimization of SAB management and patient outcomes.

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One Hundred Patients With Staphylococcus Septicemia Receiving Bacteriophage Service

Cited by 30 publications

References 0 publications

Facing Antibiotic Resistance: Staphylococcus aureus Phages as a Medical Tool

Facing Antibiotic Resistance: Staphylococcus aureus Phages as a Medical Tool

Phage treatment of human infections

Predictors of Mortality in Staphylococcus aureus Bacteremia

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