One Hundred One Simultaneous Pancreas-Kidney Transplantations: Long-Term Outcomes at a Single Center

Arjona, Álvaro; Martínez‐Cecilia, David; Ruiz-Rabelo, Juan; Muñoz, Francisco José Monzón; Lopez, Mendez M.; Agüera, María Luisa; Navarro, María Dolores; Castillo, Domingo del; López, Joaquín Luis Reyes; Aljama, Pedro; Padillo, Javier

doi:10.1016/j.transproceed.2009.06.041

Cited by 14 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pancreas transplant Pancreas transplant can be carried out in conjunction with kidney transplant, after kidney transplant, or as a pancreas transplant alone. The simultaneous kidney and pancreas transplant is the most common type of pancreas transplant carried out, representing almost 78% of pancreas transplants carried out, and transplant of the pancreas alone is generally less than 5% (1,27).…”

Section: Sedatives (Diazepam Lorazepam and Midazolam)mentioning

confidence: 99%

Dental management in transplant patients

Fabuel¹,

Esteve²,

Pérez³

2011

J Clin Exp Dent

View full text Add to dashboard Cite

Introduction: Transplant is the replacement with therapeutic purposes, of organs, tissues or cellular material for others, from a donor who is usually a human, alive or dead. In recent years, transplant organs have been developed by the advances that have occurred with immunosuppressive drugs and medical-surgical technology. Due to the frequency of transplants that are performed today, it is common to find these patients in dental clinics. Objectives: To review the literature on oral manifestations in transplant patients and general dental management and according to transplant organs (heart, lung, liver, kidney, pancreas and bone marrow). Material and Methods: For the literature review, we carried out a search in Pubmed / Medline database using limits and keywords according to the controlled vocabulary "Medical Subject Headings" (MeSH). We obtained a total of 30 articles (eight literature reviews, three randomized clinical trials, one cohort study, three case-control studies, eight clinical case series and seven cross-sectional studies). Results and discussion: We describe the most common oral manifestations in transplant patients (viral, bacterial and fungal infections, gingival enlargement secondary to drug therapy and higher risk in the development of oral malignancy) and the special dental management that should be carried out on these patients, generally and specifically according to the type of transplant.

show abstract

Section: Sedatives (Diazepam Lorazepam and Midazolam)mentioning

confidence: 99%

Dental management in transplant patients

Fabuel¹,

Esteve²,

Pérez³

2011

J Clin Exp Dent

View full text Add to dashboard Cite

show abstract

“…4 For example, while the mortality rates between bladder drainage (BD) and enteric drainage (ED) are comparable, the rate of technical complications and failure is higher in ED transplantation. [5][6][7] In fact, pancreas transplantation with BD is associated with significantly fewer early complications, such as anastomotic leak and intra-abdominal infections, all of which contribute to lower relaparotomy rates. 8 BD grafts also have the additional benefit that anastomotic leaks can be treated conservatively, whereas those linked to ED often require surgical intervention.…”

Section: Introductionmentioning

confidence: 99%

Bladder-Drained Pancreas Transplantation: Urothelial Innate Defenses and Urinary Track Infection Susceptibility

Byrne

Singh

Mowbray

et al. 2019

Journal of Surgical Research

View full text Add to dashboard Cite

show abstract

“…8 It has been most widely applied in type 1 diabetes with renal failure (IDDM-RF), particularly when done as a simultaneous pancreas kidney transplant (SPK) with increased survival rate compared with solitary kidney transplants or dialysis. [8][9][10][11] The rationale for a SPK is that it is an appropriate therapy for patients with IDDM-RF. The trade-off for such patients is the additional operative risk associated with pancreas transplant, as they are obligated to lifelong chronic immunosuppression due to their need for renal transplant.…”

Section: Introductionmentioning

confidence: 99%

Is simultaneous pancreas kidney transplant the most cost-effective strategy for type 1 diabetes patients with renal failure?

Ong¹,

Lee

Lim³

et al. 2015

Proceedings of Singapore Healthcare

View full text Add to dashboard Cite

Introduction: Simultaneous pancreas kidney transplant (SPK) has shown beneficial outcomes in type 1 diabetes patients with renal failure (IDDM-RF). The objective of this study was to assess its cost-effectiveness compared with other treatment strategies for IDDM-RF. Methods: A decision analytic model was developed for IDDM-RF treatment with four possible strategies: deceased donor kidney transplant (DDKT), living donor kidney transplant (LDKT), SPK and dialysis. A cost-utility analysis from the healthcare provider perspective was conducted based on a five-year model. Local data were used whenever possible except for SPK survival variables, wherein data from United Network for Organ Sharing and Scientific Registry of Transplant Recipients were used. Sensitivity analyses were performed to evaluate the impact of uncertainties around key variables. Results: In the baseline analysis, LDKT was the most cost-effective strategy with the lowest cost per quality-adjusted life year gained, i.e. SGD77,068, followed by SPK (SGD82,991), DDKT (SGD92,432) and dialysis (SGD181,192). The DDKT was extended dominated by dialysis and LDKT strategies. Incremental cost-effectiveness ratios with dialysis as a reference for LDKT and SPK strategies were SGD43,094 and SGD56,201, respectively. Both strategies are considered highly cost-effective under World Health Organization (WHO) guidelines. In the sensitivity analysis, a 6% increase in both SPK kidney graft survival and patient survival would make SPK the most cost-effective strategy. Conclusions: Both LDKT and SPK are highly cost-effective strategies in the treatment of IDDM-RF. SPK is potentially the most cost-effective strategy if a 6% increase in both SPK kidney graft survival and patient survival is achieved.

show abstract

One Hundred One Simultaneous Pancreas-Kidney Transplantations: Long-Term Outcomes at a Single Center

Cited by 14 publications

References 10 publications

Dental management in transplant patients

Dental management in transplant patients

Bladder-Drained Pancreas Transplantation: Urothelial Innate Defenses and Urinary Track Infection Susceptibility

Is simultaneous pancreas kidney transplant the most cost-effective strategy for type 1 diabetes patients with renal failure?

Contact Info

Product

Resources

About