One Hundred Intracranial Meningiomas Found Incidentally at Necropsy

Wood, Matthew W.; White, Robert J.; Kernohan, James W.

doi:10.1097/00005072-195707000-00005

Cited by 88 publications

(19 citation statements)

References 3 publications

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“…Mirimanoff [19] concludes that age and sex are irrelevant, whereas the site of the tumor and subtotal removal are more important factors leading to recurrence. Multiplicity has been reported in the literature as occuring in 2.4 % to 16 % of cases [5,9,16,24,28]. On the other hand we share the idea of Mahmood et al [17], that the rate of recurrence for benign meningiomasis actually lower than reported, and most of what has been considered as recurrence is in fact a regrowth of an incompletely removed meningioma.…”

Section: Discussionsupporting

confidence: 83%

Intracranial meningiomas. Analysis of 344 surgically treated cases

et al. 1998

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The authors present 344 (230 females, 114 males) surgical cases of intracranial meningioma. A total of 370 interventions (344 primary procedures, 10 reexplorations for neurologic deterioration, 16 operations for recurrence) were made. Mean follow-up was 38 months. The overall evaluation revealed that 306 (88.95%) patients were completely normal or in a better condition than before operation. 18 (5.23%) were in a worse condition after operation and 20 (5.81%) died. Results suggested that complications and mortality were mostly related to localization and large volume; we also still have problems with aggressive and malignant meningiomas.

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Section: Discussionsupporting

confidence: 83%

Intracranial meningiomas. Analysis of 344 surgically treated cases

et al. 1998

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“…This is in contrast to the materials previously presented containing 3/6 astrocytomas [11], 9/19 astrocytomas [15], 9/20 astrocytomas [16], and 8/19 astrocytomas [17], while only 1/6 [11], 1/19 [15], 3/20 [16], and 2/19 [17] were meningiomas. The mean age of our four meningioma cases in fraction I (sudden unexpected deaths caused by unknown tumors), was 68 years, closely to the mean age of 70 years in a material of meningiomas found incidentally at autopsy [19]. None of our meningiomas were multiple.…”

Section: Discussionsupporting

confidence: 75%

Neoplastic disease in a medicolegal autopsy material

Gezelius¹,

Eriksson²

1988

Z Rechtsmed

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Only a small fraction of sudden unexpected deaths are caused by neoplastic disease and thus subject ot medicolegal autopsy. The medicolegal autopsy forms an opportunity to study not only medically diagnosed and treated neoplasms, but also the natural evolution of untreated disease. In a series of 7,020 consecutive medicolegal autopsies in northern Sweden, we found 171 cases with malignant and/or intracranial neoplasms. In 41 cases, sudden death was caused by previously unknown tumors. The most common mechanisms of death in this group were disseminated cancer, intracranial tumors, pulmonary thromboembolism, hemoptysis, and aspiration of blood, and the most common locations were the bronchi and the lung. In some of these cases, the mechanism was sometimes dramatic, raising a question of violent death or intoxication. In 30 cases, sudden unexpected death was caused by previously known tumors, and also in this group disseminated cancer was the most common cause of death, and the most common locations were the bronchi and the lung. In 22 cases, tumors were found suicidal cases; in 14 of these, the tumor was considered to be a major causative factor to the suicide, while in eight cases the tumor was considered to be an incidental finding. The expected number of cancers in the 1,060 suicides investigated in this series was 27, according to the official cancer prevalence data. Thus, a possible over-representation of suicides among persons with cancer seems doubtful and needs further exploration.

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“…It is of course general experience that of all intracranial tumours meningiomas are the most likely to be missed. In the series of Wood et al (1957), from the Mayo Clinic, of 300 brain tumours -discovered incidentally at necropsy one-third were meningiomas. Cushing (1938) found that the interval between onset of symptoms and diagnosis was on the average eight years, and, exceptionally, as long as 20 or even 30 years.…”

Section: Discussionmentioning

confidence: 99%