One Hundred Consecutive Patients Treated with Magnetic Sphincter Augmentation for Gastroesophageal Reflux Disease: 6 Years of Clinical Experience from a Single Center

Bonavina, Luigi; Saino, Greta; Bona, Davide; Sironi, Andrea; Lazzari, Veronica

doi:10.1016/j.jamcollsurg.2013.04.039

Cited by 120 publications

(105 citation statements)

References 19 publications

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“…The mean DeMeester score decreased from 36.6 to 13.5 (p \ 0.001), and % time pH \ 4 decreased from 10.9 to 3.3 (p \ 0.001) [9 • ]. These results appear to be durable with post-implantation pH studies at a mean of 4.2 years in 20 patients showing % time pH \ 4 was lowered from 8 to 3.2 %, and the DeMeester score was reduced from 30.1 to 11.2 [10]. Normalization of pH (% time pH \ 4 for B4.5 % of the time) was 67 % (20/30) at last follow-up and 75 % (15/20) at 5 years [10].…”

Section: Outcomes and Results Of Linxmentioning

confidence: 72%

“…The symptom of regurgitation was significantly improved from nearly 60-1 % 3 years after device implantation [9 • ]. Bloating was reported in only 2 % (2/100) of patients, while 99 % (99/100) of patients reported ability to belch and vomit at follow-up [10]. Lastly, patient satisfaction was reported in 87 % (83/95) of patients at last follow-up [10].…”

Section: Outcomes and Results Of Linxmentioning

confidence: 98%

“…The current outcome data on LINX are derived from two major publications that evaluated 100 patients from the USA [9 • ] and 100 patients from Italy [10]. Patients in both trials were among the first to undergo device implantation, and the majority were part of a clinical trial.…”

Section: Outcomes and Results Of Linxmentioning

confidence: 99%

“…In both studies, the patient's GERD symptoms as measured by the GERD HRQL showed significant (C50 %) improvement from baseline in 92 % [9 • ] and a normalization of the median GERD-HRQL from 16 to 2 on PPIs before placement [10]. The symptom of regurgitation was significantly improved from nearly 60-1 % 3 years after device implantation [9 • ].…”

Section: Outcomes and Results Of Linxmentioning

confidence: 99%

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New Options for the Management of GERD

Wilson

Louie

2014

Curr Surg Rep

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Novel GERD treatment modalities have emerged over the past decade as alternatives to proton pump inhibitors or traditional laparoscopic Nissen fundoplication. Four new devices-LINX, TIF, EndoStim and Stretta-have attempted to improve upon the limitations of these traditional therapies. While each is promising, only the LINX device addresses the patient's symptoms, achieves objective control of acid and has limited the need for additional therapies. Further comparative research and longer term follow-up are necessary to determine the role of these therapies in the algorithm of GERD management.

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Section: Outcomes and Results Of Linxmentioning

confidence: 72%

Section: Outcomes and Results Of Linxmentioning

confidence: 98%

Section: Outcomes and Results Of Linxmentioning

confidence: 99%

Section: Outcomes and Results Of Linxmentioning

confidence: 99%

See 2 more Smart Citations

New Options for the Management of GERD

Wilson

Louie

2014

Curr Surg Rep

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“…There have also been two other large studies demonstrating excellent results with the LINX device (85 % success rate) [11,12].…”

Section: The Linx Reflux Management System (Torax Medical)mentioning

confidence: 92%

Gastroesophageal Reflux Disease: Diagnosis and Patient Selection

Singhal

Khaitan

2014

Indian J Surg

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Gastroesophageal reflux disease (GERD) has a high prevalence worldwide. Recent reports have noted a high prevalence even in Asian countries. GERD significantly affects the quality of life and can present with a wide variety of symptoms. Not all reflux is acid, and non-acid reflux disease can be more difficult to diagnose and can lead to a variety of extra-esophageal symptoms. Although proton pump inhibitors (PPIs) are effective in the majority of patients, but they are not without side effects, and their effect often diminishes with time. For patients who do not desire to be on long-term PPIs or have incomplete symptom resolution with medication, various endoscopic and minimally invasive treatment modalities are now available. The etiology of GERD can be multifactorial including dysfunctional LES, presence of a hiatal hernia, and transient lower esophageal sphincter relaxations (TLESRs). We hence believe that the treatment should be individualized to the cause of the reflux. In the following review, we describe the etiology of reflux disease and attempt to lay a framework for the diagnosis and selection of patients for the various interventions available for treatment, along with their evidence base.

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New Surgical Treatments for GERD

Bell¹

2021

The Esophagus

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One Hundred Consecutive Patients Treated with Magnetic Sphincter Augmentation for Gastroesophageal Reflux Disease: 6 Years of Clinical Experience from a Single Center

Cited by 120 publications

References 19 publications

New Options for the Management of GERD

New Options for the Management of GERD

Gastroesophageal Reflux Disease: Diagnosis and Patient Selection

New Surgical Treatments for GERD

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