One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23

Abstract

One hundred and twenty-seven cultured human tumor cell lines produced tumors after sc inoculation of 1-20 million cells into nude mice. They included 56 carcinoma lines, 14 sarcoma lines, and 57 lines from miscellaneous tumors and were all glucose-6-phosphate dehydrogenase type B. Twenty-nine percent of the lines produced tumors of 1 cm3 size within 1 month and 41% in the second month after inoculation. The histopathology correlated with the human tumor of origin in all cases.

The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice

“…The lifespan of these mice was similar to healthy nude mice. 28 The mean tumor volumes in groups II, III, and IV at the time of death were 43-, 12-, 26-fold, respectively, compared with group I (P < .01). The tumor-bearing mice in groups II -IV suffered from ascites and wasting, and peritoneal carcinosis nodules were present in a subset of these mice.…”

“…The lifespan of these mice was similar to healthy nude mice. 28 Previously, cytotoxic gene therapy has been tested for human RCC in a subcutaneous nude mouse model 5 using cytosine deaminase and HSV-tk gene therapy. In this study, HSV-tk, coupled with acyclovir, failed to demonstrate any antitumor effect.…”

Concanavalin A acceptor glycoproteins: A new type of marker for the classification of tumour cells

“…In a similar comparison with another adenocarcinoma line, Ger (Grant et al, 1979) ..CALU Figure 6 Con A acceptor glycoproteins from human carcinoma cell lines. The cell lines were the lung carcinoma CaLu-l and the colon carcinoma HT29 (Fogh et al, 1977). The diagram on the right shows the spots which are common to both cell lines.…”

Comprehensive genetic and functional characterization of IPH‐926: a novel CDH1‐null tumour cell line from human lobular breast cancer

“…Recently, it was proposed that the cell line MDA-MB-134 might be derived from an ILBC [10]. However, MDA-MB-134 was originally reported to be derived from a ductal mammary carcinoma [21] is widely perceived as a ductal breast cancer cell line [e.g., 15], usually non-tumourigenic in vivo [15,18,[21][22][23] and lacking E-cadherin expression due to a homozygous mutation of the CDH1 gene [24]. However, identical allozyme phenotype patterns in the MDA-MB-134 and the MDA-MB-309 cell lines raised concerns about a potential cross-contamination or mis-identification of both cell lines early after their establishment [25].…”