One-Hour Postload Plasma Glucose Levels Are Associated with Kidney Dysfunction

Abstract

Background and objectives: A cutoff of 155 mg/dl for 1-hour postload plasma glucose (1hPG) during the oral glucose tolerance test (OGTT) is able to identify patients who are at high risk for type 2 diabetes and vascular atherosclerosis. We aimed to examine whether individuals with 1hPG >155 mg/dl are also at increased risk for chronic kidney disease (CKD).Design, setting, participants, & measurements: Atherosclerosis risk factors, OGTT, and estimated GFR by Chronic Kidney Disease Epidemiology Collaboration equation were analyzed in 1075 white individuals without diabetes.Results: The area under the receiver operating characteristic curve for 1hPG was the highest (0.700) compared with the areas under the receiver operating characteristic curve of 0, 30-minute, and 2-hour glucose concentrations. Individuals with 1hPG >155 mg/dl had a worse cardiometabolic risk profile, exhibiting significantly higher body mass index, BP, triglycerides, and fasting insulin levels and lower HDL, IGF-1 levels, and insulin sensitivity, than individuals with 1hPG <155 mg/dl. Estimated GFR was significantly lower in individuals with 1hPG >155 mg/dl. In a logistic regression model adjusted for age and gender, individuals with 1hPG >155 mg/dl showed an increased risk for CKD compared with individuals with 1hPG <155 mg/dl. When the logistic regression analysis was restricted to individuals who had normal glucose tolerance, those with 1hPG >155 mg/dl showed a higher risk for CKD compared with individuals with 1hPG <155 mg/dl.Conclusions: These data suggest that a cutoff point of 155 mg/dl for the 1hPG during OGTT may be helpful in the identification of individuals who are at increased risk for CKD.

Plasma complement C3 levels are associated with insulin secretion independently of adiposity measures in non-diabetic individuals

“…The design of the CATAMERI study has been described in detail elsewhere [16,22,23]. Here, we analyzed only the 1010 non-diabetic individuals, out of the total 1445 participants to the CATAMERI study, for whom the full set of covariates was available.…”

“…To the best of our knowledge, there is no information on the independent association between plasma complement C3 concentrations and insulin secretion after adjustments for potential confounders, including measures of adiposity, insulin sensitivity, lipids, and other inflammatory markers. To address this question, we exploited the CATAnzaro MEtabolic RIsk factors (CATAMERI) [16,22,23] study, a large collection of subjects with a wide range of body mass index (BMI) in whom insulin secretion was measured during an oral glucose tolerance test (OGTT).…”

Characterization of left ventricular mass in individuals at risk for type 2 diabetes identified by HbA1c levels according to the American Diabetes Association criteria

“…There is evidence that FPG and 2-h PG in the range diagnostic for IFG and IGT have an impact on cardiac geometry and function and are associated with left ventricular hypertrophy (LVH), a well-established predictor of cardiovascular morbidity and mortality [3][4][5]. Whether HbA1c is a better indicator of LVH as compared with other glycemic parameters is still unsettled, and requires detailed comparisons in large cohorts since the concordance of prediabetes definitions is modest [6].To address this issue we recruited 738 White subjects participating to the CATAMERI study, a cross-sectional study assessing cardiometabolic risk factors in individuals carrying at least one risk factor including overweight, hypertension, dyslipidemia, dysglycemia, and family history for T2DM [7]. The protocol was approved by the Comitato Etico Azienda Ospedaliera "Mater Domini" and written informed consent was obtained from all participants in accordance with principles of Helsinki Declaration.…”

“…To address this issue we recruited 738 White subjects participating to the CATAMERI study, a cross-sectional study assessing cardiometabolic risk factors in individuals carrying at least one risk factor including overweight, hypertension, dyslipidemia, dysglycemia, and family history for T2DM [7]. The protocol was approved by the Comitato Etico Azienda Ospedaliera "Mater Domini" and written informed consent was obtained from all participants in accordance with principles of Helsinki Declaration.…”

The utility of serum glucose measurement at 1 hour of the oral glucose tolerance test

“…Italian authors published research on the risk of renal dysfunction and its association with early OGTT measurement values [16].…”