One hertz repetitive transcranial magnetic stimulation over dorsal premotor cortex enhances offline motor memory consolidation for sequence‐specific implicit learning

Meehan, Sean K.; Zabukovec, Jeanie R.; Dao, Elizabeth; Cheung, Katharine L.; Linsdell, Meghan A.; Boyd, Lara A.

doi:10.1111/ejn.12291

Cited by 22 publications

(26 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the behavioral level, it was found that the practice in the eye‐controlled version of the tracking task was related with a better performance in such a modality of motor control (Figure a). This result is consistent with those obtained in many related studies where the participants were trained in similar sensorimotor tracking tasks but using the hand as an effector (Ewolds, Broeker, de Oliveira, Raab, & Kuenzell, ; Lang, Gapenne, Aubert, & Ferrel‐Chapus, ; Meehan et al, ; ; Wadden et al, ; ; ; Zhu et al, ). These tracking tasks require different perceptive, executive and motor functions (e.g., visuospatial analysis, visuospatial attention, visuomotor association, motor execution, or motor programming) (Lutz, Martin, & Jaencke, ), and performance improvements occur as participants learn new kinematics or dynamics.…”

Section: Discussionsupporting

confidence: 90%

Neurofunctional correlates of eye to hand motor transfer

Modroño

Socas

Hernández‐Martín

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

This work investigates the transfer of motor learning from the eye to the hand and its neural correlates by using functional magnetic resonance imaging (fMRI) and a sensorimotor task consisting of the continuous tracking of a virtual target. In pretraining evaluation, all the participants (experimental and control group) performed the tracking task inside an MRI scanner using their right hand and a joystick. After which, the experimental group practiced an eye‐controlled version of the task for 5 days using an eye tracking system outside the MRI environment. Post‐training evaluation was done 1 week after the first scanning session, where all the participants were scanned again while repeating the manual pretraining task. Behavioral results show that the training in the eye‐controlled task produced a better performance not only in the eye‐controlled modality (motor learning) but also in the hand‐controlled modality (motor transfer). Neural results indicate that eye to hand motor transfer is supported by the motor cortex, the basal ganglia and the cerebellum, which is consistent with previous research focused on other effectors. These results may be of interest in neurorehabilitation to activate the motor systems and help in the recovery of motor functions in stroke or movement disorder patients.

show abstract

Section: Discussionsupporting

confidence: 90%

Neurofunctional correlates of eye to hand motor transfer

Modroño

Socas

Hernández‐Martín

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…; Meehan et al . ). The different neural pathways involved in consolidation of different forms of learning may be differentially influenced by a short bout of high intensity exercise.…”

Section: Discussionmentioning

confidence: 97%

“…While consolidation of the learning in both tasks probably relies heavily on primary motor cortex (M1) (Muellbacher et al 2002;Luft et al 2004), recent evidence suggests that a complex network involving not only M1 but also the cerebellum is involved in the consolidation of sensorimotor adaptation-based learning (Della-Maggiore et al 2017). This is not the case for consolidation of a visuomotor tracking task, which relies heavily on the premotor cortex along with M1 (Boyd & Linsdell, 2009;Kantak et al 2010;Meehan et al 2013). The different neural pathways involved in consolidation of different forms of learning may be differentially influenced by a short bout of high intensity exercise.…”

Section: Effect Of Exercise On Learning May Be Context Specificmentioning

confidence: 99%

A single exercise bout and locomotor learning after stroke: physiological, behavioural, and computational outcomes

Charalambous

Alcântara

French

et al. 2018

The Journal of Physiology

View full text Add to dashboard Cite

Acute high-intensity exercise coupled with motor practice improves the retention of motor learning in neurologically intact adults. However, whether exercise could improve the retention of locomotor learning after stroke is still unknown. Here, we investigated the effect of exercise intensity and timing on the retention of a novel locomotor learning task (i.e. split-belt treadmill walking) after stroke. Thirty-seven people post stroke participated in two sessions, 24 h apart, and were allocated to active control (CON), treadmill walking (TMW), or total body exercise on a cycle ergometer (TBE). In session 1, all groups exercised for a short bout (∼5 min) at low (CON) or high (TMW and TBE) intensity and before (CON and TMW) or after (TBE) the locomotor learning task. In both sessions, the locomotor learning task was to walk on a split-belt treadmill in a 2:1 speed ratio (100% and 50% fast-comfortable walking speed) for 15 min. To test the effect of exercise on 24 h retention, we applied behavioural and computational analyses. Behavioural data showed that neither high-intensity group showed greater 24 h retention compared to CON, and computational data showed that 24 h retention was attributable to a slow learning process for sensorimotor adaptation. Our findings demonstrated that acute exercise coupled with a locomotor adaptation task, regardless of its intensity and timing, does not improve retention of the novel locomotor task after stroke. We postulate that exercise effects on motor learning may be context specific (e.g. type of motor learning and/or task) and interact with the presence of genetic variant (BDNF Val66Met).

show abstract

“…Motor learning is a complex process involving a distributed network of brain areas (Floyer‐Lea & Matthews, ). Therefore, targeting an alternative cortical area that is functionally and anatomically connected to M1 may be effective in strengthening synaptic connections involved in motor learning (Meehan et al ., , ; Brodie et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Impact of 5‐Hz rTMS over the primary sensory cortex is related to white matter volume in individuals with chronic stroke

Brodie

Borich

Boyd

2014

Eur J of Neuroscience

View full text Add to dashboard Cite

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that may facilitate mechanisms of motor learning. In a recent single-blind, pseudo-randomized study, we showed that 5-Hz rTMS over ipsilesional primary somatosensory cortex followed by practice of a skilled motor task enhanced motor learning compared with sham rTMS + practice in individuals with chronic stroke. However, the beneficial effect of stimulation was inconsistent. The current study examined how differences in sensorimotor cortex morphology might predict rTMS-related improvements in motor learning in these individuals. High-resolution T1-weighted magnetic resonance images were acquired and processed in FreeSurfer using a newly developed automated, whole brain parcellation technique. Gray matter and white matter volumes of the ipsilesional primary somatosensory and motor cortices were extracted. A significant positive association was observed between the volume of white matter in the primary somatosensory cortex and motor learning-related change, exclusively in the group that received active 5-Hz rTMS. A regression model with age, gray matter and white matter volumes as predictors was significant for predicting motor learning-related change in individuals who received active TMS. White matter volume predicted the greatest amount of variance (47.6%). The same model was non-significant when volumes of the primary motor cortex were considered. We conclude that white matter volume in the cortex underlying the TMS coil may be a novel predictor for behavioral response to 5-Hz rTMS over the ipsilesional primary somatosensory followed by motor practice.

show abstract

One hertz repetitive transcranial magnetic stimulation over dorsal premotor cortex enhances offline motor memory consolidation for sequence‐specific implicit learning

Cited by 22 publications

References 48 publications

Neurofunctional correlates of eye to hand motor transfer

Neurofunctional correlates of eye to hand motor transfer

A single exercise bout and locomotor learning after stroke: physiological, behavioural, and computational outcomes

Impact of 5‐Hz rTMS over the primary sensory cortex is related to white matter volume in individuals with chronic stroke

Contact Info

Product

Resources

About