“One Health” perspective on prevalence of co-existing extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae: a comprehensive systematic review and meta-analysis

Abstract

Background The Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) bacterial isolates that produce extended-spectrum β-lactamases (ESBLs) contribute to global life-threatening infections. This study conducted a systematic review and meta-analysis on the global prevalence of ESBLs in co-existing E. coli and K. pneumoniae isolated from humans, animals and the environment. Methods The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) [ID no: CRD42023394360]. This study was carried out following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. One hundred and twenty-six eligible studies published on co-existing antibiotic resistance in E. coli and K. pneumoniae between 1990 and 2022 were included. Results The pooled prevalence of ESBL-producing E. coli and K. pneumoniae was 33.0% and 32.7% for humans, 33.5% and 19.4% for animals, 56.9% and 24.2% for environment, 26.8% and 6.7% for animals/environment, respectively. Furthermore, the three types of resistance genes that encode ESBLs, namely blaSHVblaCTX−M,blaOXA, and blaTEM, were all detected in humans, animals and the environment. Conclusions The concept of “One-Health” surveillance is critical to tracking the source of antimicrobial resistance and preventing its spread. The emerging state and national surveillance systems should include bacteria containing ESBLs. A well-planned, -implemented, and -researched alternative treatment for antimicrobial drug resistance needs to be formulated.

Antibiotic resistance and virulence profiles of Proteus mirabilis isolated from broiler chickens at abattoir in South Africa

“…In this study, carbapenemase genes were detected in two (7.6%) P. mirabilis isolates. Since direct transmission of extended‐spectrum cephalosporin‐resistant isolates from animals to humans has been documented, this is a serious concern for veterinary medicine as well as human medicine (Marshall & Levy, 2011; Ramatla et al., 2024).…”

The importance of “one health approach” to the AMR study and surveillance in Angola and other African countries

“…Another study did a comprehensive review and meta-analysis to determine the global prevalence of ESBL in co-existing E. coli and K. pneumoniae isolates from humans, animals, and the environment [ 116 ]. A total of 126 studies from Asia ( n = 80), Africa (n = 37), Europe (n = 11), and North America (n = 8), published from 1990 to 2022, were analyzed.…”

In silico characterization of bla OXA -carrying plasmids in Escherichia coli

“…Previous investigation showed that the infections caused by ESBLsproducing E. coli are related to fewer therapeutic options, longer hospital stays, and higher health costs than those caused by non-ESBLs-producing E. coli (Karlowsky et al, 2020). Moreover, a comprehensive systemic review and meta-analysis suggested that the prevalence of ESBLs-producing E. coli has reached 33.0%, 33.5%, and 56.9% for human, animals, and environments, respectively (Ramatla et al, 2023). The intestinal carriage of ESBLs-producing E. coli displayed an almost 8-fold increase from 2.6% in 2003 to 21.1% in 2015 (Bezabih et al, 2021).…”