One Health aspects &amp; priority roadmap for fungal diseases : A mini-review

Banerjee, Sayantan; Denning, David W.; Chakrabarti, Arunaloke

doi:10.4103/ijmr.ijmr_768_21

Cited by 26 publications

(20 citation statements)

References 68 publications

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“…Though we didn't find any case with post transplant, haematological malignancies, post-pulmonary tuberculosis in our study. Nevertheless, these are found as potential risk factors in published literature on mucormycosis; hence there is a strong association of co-morbidities and fungalcoinfection (5,8,9,21). History of corticosteroid intake for the treatment of COVID-19 was present in 76.3 -88% of cases in several studies (10,24).…”

Section: Discussionmentioning

confidence: 99%

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Mucormycosis During Second Wave Of COVID-19 in India: Exploratory Analysis From Tertiary Care Centre Of Uttar Pradesh

Singh

Bansal

Kumar

et al. 2021

Indian J Community Health

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Background: In April and May 2021, India faced massive second wave of COVID-19 pandemic and then became the hotspots of mucormycosis across globe. Hence, we planned the first analysis of mucormycosis in Uttar Pradesh. Aim and Objectives: coThe objectives were to explore the epidemiology, vaccination status, clinical features, microbiological findings, treatment of mucormycosis and outcome. Material and Methods: This was an observational study of mucormycosis at tertiary care centre of Agra, Uttar Pradesh, India from 20 May 2021 to 15 July 2021. Results: 98 patients’ data with mucormycosis was analyzed. Patients had median age of 55 years. COVID-19 infection was present in 69.4% of participants and diabetes mellitus was present as underlying co-morbid condition in more than 85% of patients. 91.8 % of cases were unvaccinated with steroid consumption in almost 60% of patients. R. arrhizus was among the most common agent while we found less commonly reported fungi like R.homothallicus, Apophysomyces, Cunninghamella. 41.8% of cases were successfully treated and 16.3% of cases expired. Conclusion: Diabetes mellitus was labeled as major predisposing factor and most patients were unvaccinated. Awareness about fungal infections, rigorous monitoring of chronic diseases, judicious use of drugs, early diagnosis and prompt treatment is decisive for better outcome.

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Section: Discussionmentioning

confidence: 99%

“…(4,5,6,7). Emerging fungal infections is a growing concern worldwide, more so in India due to temperature adaptation, under-diagnosis, millions of diabetics and poor awareness (5,8,9). Globally, the prevalence of mucormycosis varied from 0.005 to 1.7 per million populations, while it is nearly 80 times higher (0.14 per 1000) in India (10).…”

Section: Introductionmentioning

confidence: 99%

Mucormycosis During Second Wave Of COVID-19 in India: Exploratory Analysis From Tertiary Care Centre Of Uttar Pradesh

Singh

Bansal

Kumar

et al. 2021

Indian J Community Health

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“…About 1 billion people in the world are thought to suffer from a fungal infection, an increase due to host factors as well as new mechanisms of virulence or resistance. Additionally, recent environmental and epidemiological evidence of endemic mycoses shows changes in the geographic prevalence of pathogenic fungi worldwide [ 327 , 328 ]. It has recently been suggested that invasive mycoses are undergoing etiopathogenic changes that are making these diseases even more prevalent, and that the geographical distribution is moving towards geographical areas where it did not exist before [ 329 ].…”

Section: Clinical Use Of Polyenesmentioning

confidence: 99%

Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications

et al. 2022

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This review examined a collection of studies regarding the molecular properties of some polyene antibiotic molecules as well as their properties in solution and in particular environmental conditions. We also looked into the proposed mechanism of action of polyenes, where membrane properties play a crucial role. Given the interest in polyene antibiotics as therapeutic agents, we looked into alternative ways of reducing their collateral toxicity, including semi-synthesis of derivatives and new formulations. We follow with studies on the role of membrane structure and, finally, recent developments regarding the most important clinical applications of these compounds.

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“…Nearly 6 million different species of fungi exist, and about 600 of them can cause human disease. Fungal diseases represent a health concern, because of high mortality rates and constant problems with antifungal resistance . There are no licensed vaccines to prevent fungal diseases.…”

Section: The Need For New Antifungalsmentioning

confidence: 99%

Antifungal Development and the Urgency of Minimizing the Impact of Fungal Diseases on Public Health

Oliveira

Bezerra

Rodrigues

2022

ACS Bio Med Chem Au

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One Health aspects & priority roadmap for fungal diseases : A mini-review

Cited by 26 publications

References 68 publications

Mucormycosis During Second Wave Of COVID-19 in India: Exploratory Analysis From Tertiary Care Centre Of Uttar Pradesh

Mucormycosis During Second Wave Of COVID-19 in India: Exploratory Analysis From Tertiary Care Centre Of Uttar Pradesh

Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications

Antifungal Development and the Urgency of Minimizing the Impact of Fungal Diseases on Public Health

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