One Health Approach to Control Canine Rabies in Thailand: The Chiang Mai Model

Petsophonsakul, Wilaiwan; Inoue, Satoshi

doi:10.1079/9781800622975.0004

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…The average antibody level was 8.34 ± 26.11 IU/ml (< 0.02-191.18 IU/ml). Less than half of the forest dogs had protective immunity against rabies; this failed to achieve the targeted vaccination coverage of ≥70% (Petsophonsakul et al, 2019). The immunity of forest dogs can act as a buffer zone for rabies control along the borders between the forest and the city.…”

Section: Challenge Iv: Evaluating Rabies Vaccination In High-risk Exp...mentioning

confidence: 99%

One Health for Dog-mediated Rabies Elimination in Asia

2023

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The views expressed in this publication are those of the author(s) and do not necessarily represent those of, and should not be attributed to, CAB International (CABI). Any images, figures and tables not otherwise attributed are the author(s)' own. References to internet websites (URLs) were accurate at the time of writing. CAB International and, where different, the copyright owner shall not be liable for technical or other errors or omissions contained herein. The information is supplied without obligation and on the understanding that any person who acts upon it, or otherwise changes their position in reliance thereon, does so entirely at their own risk. Information supplied is neither intended nor implied to be a substitute for professional advice. The reader/user accepts all risks and responsibility for losses, damages, costs and other consequences resulting directly or indirectly from using this information. CABI's Terms and Conditions, including its full disclaimer, may be found at https://www.cabi.org/ terms-and-conditions/.

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Section: Challenge Iv: Evaluating Rabies Vaccination In High-risk Exp...mentioning

confidence: 99%

One Health for Dog-mediated Rabies Elimination in Asia

2023

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One-dose intradermal rabies booster enhances rabies antibody production and avidity maturation

Kewcharoenwong,

Freeouf,

Nithichanon

et al. 2024

Med Microbiol Immunol

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The incidence of rabies in Thailand reached its peak in 2018 with 18 human deaths. Preexposure prophylaxis (PrEP) vaccination is thus recommended for high-risk populations. WHO has recently recommended that patients who are exposed to a suspected rabid animal and have already been immunized against rabies should receive a 1-site intradermal (ID) injection of 0.1 mL on days 0 and 3 as postexposure prophylaxis (PEP). In Thailand, village health and livestock volunteers tasked with annual dog vaccination typically receive only a single lifetime PrEP dose and subsequent boosters solely upon confirmed animal bites. However, the adequacy of a single PrEP dose for priming and maintaining immunity in this high-risk group has not been evaluated. Therefore, our study was designed to address two key questions: (1) sufficiency of single-dose PrEP—to determine whether a single ID PrEP dose provides adequate long-term immune protection for high-risk individuals exposed to numerous dogs during their vaccination duties. (2) Booster efficacy for immune maturation—to investigate whether one or two additional ID booster doses effectively stimulate a mature and sustained antibody response in this population. The level and persistence of the rabies antibody were determined by comparing the immunogenicity and booster efficacy among the vaccination groups. Our study demonstrated that rabies antibodies persisted for more than 180 days after cost-effective ID PrEP or the 1st or the 2nd single ID booster dose, and adequate antibody levels were detected in more than 95% of participants by CEE-cELISA and 100% by indirect ELISA. Moreover, the avidity maturation of rabies-specific antibodies occurred after the 1st single ID booster dose. This smaller ID booster regimen was sufficient for producing a sufficient immune response and enhancing the maturation of anti-rabies antibodies. This safe and effective PrEP regimen and a single visit involving a one-dose ID booster are recommended, and at least one one-dose ID booster regimen could be equitably implemented in at-risk people in Thailand and other developing countries. However, an adequate antibody level should be monitored before the booster is administered.

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One Health Approach to Control Canine Rabies in Thailand: The Chiang Mai Model

Cited by 2 publications

References 4 publications

One Health for Dog-mediated Rabies Elimination in Asia

One Health for Dog-mediated Rabies Elimination in Asia

One-dose intradermal rabies booster enhances rabies antibody production and avidity maturation

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