One Health and Global Health View of Antimicrobial Susceptibility through the “Eye” of Aeromonas: Systematic Review and Meta-Analysis

Jones, Daniel C.; LaMartina, Emily Lou; Lewis, John R.; Dahl, Andreas; Nadig, Nischala; Szabó, Anikó; Newton, Ryan J.; Skwor, Troy

doi:10.1016/j.ijantimicag.2023.106848

Cited by 10 publications

(24 citation statements)

References 55 publications

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“…Aeromonas spp., discharged in final effluent have been identified with the following carbapenemases bla KPC-2, bla VIM-2, bla OXA-48, bla IMP-13, bla GES and bla MOX genes [47]. Their presence in treated effluent emphasizes the potential role Aeromonas can serve as a vehicle for transferring dangerous ARGs across environmental sectors [3], as well as an opportunist for exchanging ARGs both intra- and interspecies.…”

Section: Resultsmentioning

confidence: 99%

“…In previous work, we used Aeromonas as a global indicator species for analyzing antimicrobial resistance over a twenty-year period. We identified similar resistance levels across human, agricultural, and environmental sectors for the majority of 21 antimicrobials; the few exceptions were mainly of last resort antimicrobial like cefepime and aztreonam [3]. Among these antibiotics, wastewater contains significantly higher resistance profiles than all other sectors, which stresses that wastewater may be an origin or source for increased HGT and ARG acquisition.…”

Section: Resultsmentioning

confidence: 99%

“…Alarmingly, broad-spectrum and last-resort antibiotics are becoming more frequently employed than ever before [2]. Consequently, as these compounds' usage increases, so does the identification of bacterial strains resistant to them [3].…”

Section: Introductionmentioning

confidence: 99%

“…However, a challenge for using this tactic against AMR resides in identifying a proper indicator species. One potential indicator which has been proposed is Aeromonas [3]. This genus of bacteria resides ubiquitously in aquatic environments across the globe, including freshwater to brackish, and have been correlated with a variety of diseases among cold- and warm-blooded animals [11].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, aeromonads readily participate in both intra- and interspecies horizontal gene transfer (HGT) [14], allowing for monitoring of ARGs within an environment [15]. Aquaculture and wastewater treatment facilities, both common habitats for Aeromonas [3,16], have been identified as hot-spots of ARGs transmission [17]. Therefore, it has been proposed that aeromonads may provide a useful tool in tracking antimicrobial resistance patterns around the world [3,18].…”

Section: Introductionmentioning

confidence: 99%

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First report and characterization of a plasmid-encodedbla_SFO-1in a multi-drug resistantAeromonas hydrophilaclinical isolate

Skwor,

Jones,

Cahak

et al. 2024

Preprint

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Antibiotic resistance remains one of the most pressing public health issues facing the world today. At the forefront of this battle lies the ever-increasing identification of extended spectrum beta-lactamases and carbapenemases within human pathogens, conferring resistance towards broad-spectrum and last-resort anti-microbials. This study was prompted due to the identification of a pathogenic Aeromonas hydrophila isolate (strain MAH-4) collected from abdominal fluid, which presented a robust resistance pattern against second, third, and fourth generation cephalosporins, ertapenem, ciprofloxacin, gentamicin, levofloxacin and moxifloxacin, and beta lactam/beta-lactamase inhibitor combinations. Whole genome sequencing was performed and identified a 328 kb plasmid (pMAH4) encoding 10 antibiotic resistance genes, including blaSFO-1, blaTEM-1, and blaOXA-1 of A. hydrophia MAH-4. This is the first report of beta-lactamase SFO-1 within a clinical strain of Aeromonas. Due to the remarkable sequence identity of pMAH4 to plasmids associated with Enterobacterales genera like Klebsiella, and the extensive capabilities of Aeromonas for horizontal gene transfer, our identification of a clinical isolate encoding SFO-1 on a plasmid suggests ARG mobility between Enterobacterales and non-Enterobacterales species.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

First report and characterization of a plasmid-encodedbla_SFO-1in a multi-drug resistantAeromonas hydrophilaclinical isolate

Skwor,

Jones,

Cahak

et al. 2024

Preprint

Self Cite

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Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing

Neil,

Cheney,

Rosenzweig

et al. 2024

Appl Microbiol Biotechnol

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Aeromonas species (spp.) are well-known fish pathogens, several of which have been recognized as emerging human pathogens. The organism is capable of causing a wide spectrum of diseases in humans, ranging from gastroenteritis, wound infections, and septicemia to devastating necrotizing fasciitis. The systemic form of infection is often fatal, particularly in patients with underlying chronic diseases. Indeed, recent trends demonstrate rising numbers of hospital-acquired Aeromonas infections, especially in immuno-compromised individuals. Additionally, Aeromonas-associated antibiotic resistance is an increasing challenge in combating both fish and human infections. The acquisition of antibiotic resistance is related to Aeromonas’ innate transformative properties including its ability to share plasmids and integron-related gene cassettes between species and with the environment. As a result, alternatives to antibiotic treatments are desperately needed. In that vein, many treatments have been proposed and studied extensively in the fish-farming industry, including treatments that target Aeromonas quorum sensing. In this review, we discuss current strategies targeting quorum sensing inhibition and propose that such studies empower the development of novel chemotherapeutic approaches to combat drug-resistant Aeromonas spp. infections in humans. Key points • Aeromonas notoriously acquires and maintains antimicrobial resistance, making treatment options limited. • Quorum sensing is an essential virulence mechanism in Aeromonas infections. • Inhibiting quorum sensing can be an effective strategy in combating Aeromonas infections in animals and humans.

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Factors contributing to antibiotic misuse among parents of school-going children in Dhaka City, Bangladesh

Islam,

Shahjahan,

Azad

et al. 2024

Sci Rep

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Antimicrobial resistance (AMR) is a pressing global health concern, especially in resource-constrained countries, such as Bangladesh. This study aimed to identify the factors contributing to antibiotic misuse by assessing knowledge, attitude, and practice (KAP). A cross-sectional study was conducted from August 20 to August 30, 2022, among 704 parents of school-going children in Dhaka South City. Descriptive statistics were used to analyze the KAP, and multivariate models, including linear and ordinal logistic regression, were used to explore the associations between these factors. The findings revealed that approximately 22% of the participants were male and 78% were female. Most parents (58%) had completed higher secondary education. Approximately 45% of the respondents demonstrated moderate knowledge, 53% had uncertain attitudes, and 64% exhibited antibiotic misuse. Factors such as parental age, education level, employment status, income, child's age, and family type significantly influenced KAP. These findings emphasize the importance of targeted education and awareness initiatives to enhance knowledge and responsible antibiotic use among parents, contributing to global efforts against antibiotic resistance. The government should enforce laws and regulations regarding the misuse of antibiotics.

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One Health and Global Health View of Antimicrobial Susceptibility through the “Eye” of Aeromonas: Systematic Review and Meta-Analysis

Cited by 10 publications

References 55 publications

First report and characterization of a plasmid-encodedbla_SFO-1in a multi-drug resistantAeromonas hydrophilaclinical isolate

First report and characterization of a plasmid-encodedbla_SFO-1in a multi-drug resistantAeromonas hydrophilaclinical isolate

Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing

Factors contributing to antibiotic misuse among parents of school-going children in Dhaka City, Bangladesh

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One Health and Global Health View of Antimicrobial Susceptibility through the “Eye” of Aeromonas: Systematic Review and Meta-Analysis

Cited by 10 publications

References 55 publications

First report and characterization of a plasmid-encodedblaSFO-1in a multi-drug resistantAeromonas hydrophilaclinical isolate

First report and characterization of a plasmid-encodedblaSFO-1in a multi-drug resistantAeromonas hydrophilaclinical isolate

Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing

Factors contributing to antibiotic misuse among parents of school-going children in Dhaka City, Bangladesh

Contact Info

Product

Resources

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First report and characterization of a plasmid-encodedbla_SFO-1in a multi-drug resistantAeromonas hydrophilaclinical isolate

First report and characterization of a plasmid-encodedbla_SFO-1in a multi-drug resistantAeromonas hydrophilaclinical isolate