One giant leap for pediatric AMKL

Shand, Jessica C.

doi:10.1182/blood-2016-05-715045

Cited by 1 publication

(1 citation statement)

References 10 publications

(8 reference statements)

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“…When analysing putative interactions between known protein-protein interaction domains of JARID1A, SCL/E47 and GATA1, we show that this interaction could be directly mediated by GATA1 zinc-finger domains and the second PHD domain (PHD2) of JARID1A. Interestingly, the loss of both normal GATA1 and JARID1A function is linked with AMKL [9,38,39], suggesting a possible functional link between loss of interaction and leukemogenesis.…”

Section: Discussionmentioning

confidence: 89%

The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain

et al. 2020

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Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes result in tightly regulated cell differentiation transcriptional programmes. However, the complex functional and physical interplay between transcription factors and chromatin-modifying enzymes remains elusive. Recent evidence has implicated histone demethylases in normal haematopoietic differentiation as well as in malignant haematopoiesis. Here, we report an interaction between H3K4 demethylase JARID1A and the haematopoietic-specific master transcription proteins SCL and GATA1 in red blood cells. Specifically, we observe a direct physical contact between GATA1 and the second PHD domain of JARID1A. This interaction has potential implications for normal and malignant haematopoiesis.

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Section: Discussionmentioning

confidence: 89%