One experience with ‘lower’ or ‘higher’ intensity stressors, respectively enhances or diminishes responsiveness to haloperidol weeks later: implications for understanding drug variability

Antelman, Seymour M.; Caggiula, Anthony R.; Kocan, Donna; Knopf, Steven; Meyer, Donald L.; Edwards, David J.; Barry, Herbert

doi:10.1016/0006-8993(91)91709-a

Cited by 73 publications

(47 citation statements)

References 17 publications

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“…Among drugs (in addition to those already noted)-and chemicals-it has been observed with the stimulants, amphetamine and cocaine, [11][12][13][14] anxiolytic, anxiogenic and hypnotic benzodiazepines, ie, diazepam, phine, 21 clenbuterol, 22 clomipramine, [23][24][25] 2-deoxy-dglucose, 19 the cytokines, interleukin-1 beta, 26,27 interleukin-2, 28 tumor necrosis factor-alpha, 29 50 and vitellogenin mRNA induction. 33,34 The diversity of agents capable of inducing TDS and the wealth of endpoints affected, as well as its extremely long-lasting nature (up to at least months after a single stimulus exposure 36 ), make it apparent that it does not obey the 'rules' typically associated with pharmacological phenomena.…”

Section: Mostly Preclinical Findingsmentioning

confidence: 99%

“…It has now been shown numerous times with a diversity of stressors that this is indeed the case. Among nonchemical stressors, TDS has been induced by seconds of loud bell ringing, 51 food deprivation, 12 tailpinch, 11 shock, 40,45,52 immobilization, 19,49 needle jab, 19 the psychological stimulus of a brief period in a strange environment, 41 brain surgery, 27 a combination of some of the foregoing plus swim stress, 47 and, as noted above, ECS.…”

Section: Mostly Preclinical Findingsmentioning

confidence: 99%

“…In other words, both potentiating and inhibiting actions strengthened with the passage of time. 19 Long-term, time-dependent enhancement or inhibition of hippocampal mineralocorticoid and glucocorticoid receptor binding has also been observed following brief exposure to stressful stimuli differing in severity. 46 …”

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confidence: 99%

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Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic

2000

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This review provides both a biological and clinical perspective on Time-Dependent Sensitization (TDS), an ancient amplified memory response to threat manifest in the ability of both drugs and nondrug stressors to induce neuronal and behavioral effects which strengthen entirely as a function of the passage of time following even a single or acute exposure. Evidence is presented to show that TDS may be involved in the development of a spectrum of diseases and how drug regimens based on the principles of TDS could provide a novel and revolutionary means of treating psychiatric and other illnesses. Molecular Psychiatry (2000) 5, 350-356.

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Section: Mostly Preclinical Findingsmentioning

confidence: 99%

Section: Mostly Preclinical Findingsmentioning

confidence: 99%

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Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic

2000

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“…Strong stress causes a reduction in adrenaline concentration and affects dopamine (DA) metabolism in different brain regions, leading to the formation of one of its principal acidic metabolites, dihydroxyphenylacetic acid (DOPAC) [19,20]. On the other hand, elevated glucocorticoid concentration in the adrenal medulla enhances the induction of enzymes that control the synthesis of A from NA [21].…”

Section: Resultsmentioning

confidence: 99%

Catecholamine levels in the brain of rats exposed by inhalation to benzalkonium chloride

Świercz¹,

Grzelińska²,

Gralewicz³

et al. 2009

International Journal of Occupational Medicine and Environmental Health

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Objectives: The aim of the study was to obtain quantitative data on the effect of inhalation exposure to benzalkonium chloride (BAC) on the concentration of catecholamines and their metabolites in selected brain structures. Additionally, concentration of corticosterone (CORT) in plasma was estimated. Material and Methods: Wistar rats were subjected to a single (6-hour) or repeated (3 days, 6 h/day) exposure to BAC aerosol at ca. 30 mg/m 3 . The Waters integrated analytical system of HPLC was used to determine the plasma corticosterone. Qualitative and quantitative determinations of catecholamines and their metabolites: 3,4-dihydroxyphenylacetic (DOPAC) and homovanillic (HVA) acids were performed with the use of the Waters integrity HPLC. Results: The determinations have shown that in the BAC-exposed rats the plasma CORT concentration was several times higher than in the control rats. A significant increase of the concentration of dopamine (DA) (striatum and diencephalon) and noradrenaline (NA) (hippocampus and cerebellum) and a significant reduction of adrenaline (A) level (cortex, hippocampus, striatum and mesencephaloon) was found to occur in the brain of rats exposed to BAC compared to control. In the animals exposed to BAC, the concentration of DOPAC, a DA metabolite, was significantly reduced, but the change occurred mainly in the striatum. This resulted in a significant decrease of the DOPAC/DA and HVA/DA metabolic ratio in this structure. Conclusion: It is assumed that the alterations in the concentration of catecholamines and their metabolites in the BAC-exposed rats were related to the unexpectedly strong and persistent activation of the hypothalamo-pituitary-adrenocortical (HPA) axis evidenced by the high plasma CORT concentration.

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“…There is no doubt that inhaling TMBs, similarly as other aromatic hydrocarbons, may provoke stress response, especially in species with highly developed sense of smell [31][32][33]. Some years ago, Antelman et al showed that the changes developing after exposure to a stressor (termed by Antelman as Time-Dependent Sensitization -TDS) may, depending on the strength of the stressor, proceed in opposite directions: increased or decreased sensitivity to the inducing stressor as well as to other stressors [34,35]. It is likely that, owing to differences in the spatial configuration of the methyl groups, the PS odour is being perceived by the rat as more unpleasant or alarming, and therefore more stressful, than the HM odour (or vice versa).…”

Section: Figmentioning

confidence: 99%

Contrasting effects of 4-week inhalation exposure to pseudocumene or hemimellitene on sensitivity to amphetamine and propensity to amphetamine sensitization in the rat

Lutz¹,

Gralewicz²,

Wiaderna³

et al. 2010

International Journal of Occupational Medicine and Environmental Health

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Objectives: Some data suggest that increased behavioural sensitivity to psychostimulants may develop after exposure to volatile chemicals in common use. The purpose of the present experiment was to find out whether and in what way inhalation exposure to pseudocumene (PS) or hemimellitene (HM) at low concentrations alters behavioural sensitivity to the psychostimulant amphetamine (AMPH), and propensity to develop behavioural sensitization to AMPH. Material and Methods: Adult male Wistar rats were exposed 6 h/day, 5 days a week for 4 weeks to PS or HEM at 0, 25, 100 or 250 ppm. Behavioural sensitivity to AMPH was assessed by measuring locomotor activity of the animals in an open-field. Behavioural sensitization to AMPH was induced by a repeated AMPH treatment. Results: In rats exposed to HEM, the behavioural sensitivity to AMPH was increased, but remained unchanged in rats exposed to PS. The second testing revealed an augmented behavioural response to AMPH in control rats. In the HM exposed rats this augmenting was significantly more evident and in the PS exposed rats significantly less evident than in controls. For each of the two solvents, the concentration-effect relationship was nonlinear; out of the three concentrations used, 100 ppm was the most effective. Conclusions: The results confirm that low-level inhalation exposure to trimethylbenzene isomers may induce behavioural sensitisation and/or increase the susceptibility of the animals to develop this state upon repeated psychostimulant treatment. They show, however, that HM and PS differ markedly in their ability to induce such alterations.

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One experience with ‘lower’ or ‘higher’ intensity stressors, respectively enhances or diminishes responsiveness to haloperidol weeks later: implications for understanding drug variability

Cited by 73 publications

References 17 publications

Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic

Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic

Catecholamine levels in the brain of rats exposed by inhalation to benzalkonium chloride

Contrasting effects of 4-week inhalation exposure to pseudocumene or hemimellitene on sensitivity to amphetamine and propensity to amphetamine sensitization in the rat

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