One-electron reduction triggered nitric oxide release for ischemia-reperfusion protection

Xu, Xiaoxiang; Sun, Meiling; Luo, Xiao; Zhang, Ziqian; Su, Lin; Cui, Ling-Fei; Zhu, Zhihui; Lu, Xicun; Wang, Rui; Han, Feng; Qian, Xuhong; Yang, Youjun

doi:10.1016/j.freeradbiomed.2020.12.443

Cited by 6 publications

(5 citation statements)

References 54 publications

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“…The instantaneous reaction may be induced by the efficient absorption of UV light and the pervasive reducing substances in bio-systems. 30,44 Considering the unavoidable reducing agents in cells, choosing an appropriate wavelength for the excitation light is a possible solution. RAW 264.7 cells were treated with DAPI and NOD-NPs, then exposed to 450 nm blue light for 30 s. Fluorescence signals emerged around the cell nuclei.…”

Section: Resultsmentioning

confidence: 99%

Photo-controlled and photo-calibrated nanoparticle enabled nitric oxide release for anti-bacterial and anti-biofilm applications

Lin

et al. 2022

RSC Adv.

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Section: Resultsmentioning

confidence: 99%

Photo-controlled and photo-calibrated nanoparticle enabled nitric oxide release for anti-bacterial and anti-biofilm applications

Lin

et al. 2022

RSC Adv.

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“…Western blotting analysis was performed according to the method as described previously [ 31 ]. The equivalent amount of protein in lysates was separated by 10–15% SDS-PAGE and transferred to PVDF membrane (Millipore, Billerica, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Endothelial peroxynitrite causes disturbance of neuronal oscillations by targeting caspase-1 in the arcuate nucleus

Sun

Mao

et al. 2021

Redox Biology

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Severe anorexia limits the clinical application of cisplatin, and even leads to the discontinuation of treatment. However, the mechanisms underlying cisplatin-induced anorexia are unknown. Herein, we demonstrated that cisplatin could affect neuronal gamma oscillations and induce abnormal neuronal theta-gamma phase-amplitude coupling in the arcuate nucleus (Arc) of the hypothalamus, and these findings were associated with significantly decreased food intake and weight loss in mice. Chemogenetic activation of AgRP neurons in the Arc reversed the cisplatin-induced food intake reduction in mice. We further demonstrated that endothelial peroxynitrite (ONOO − ) formation in the Arc induced nitrosative stress following cisplatin treatment via a previously uncharacterized pathway involving neuronal caspase-1 activation. Strikingly, treatment with the ONOO − scavenger uric acid (UA) reversed the reduced action potential (AP) frequency of AgRP neurons and increased the AP frequency of POMC neurons induced by SIN1, a donor of ONOO − , in the Arc, as determined by whole-cell patch-clamp electrophysiological recording. Consistent with these findings, UA treatment effectively alleviated cisplatin-induced dysfunction of neuronal oscillations and neuronal theta-gamma phase-amplitude coupling in the Arc of mice. Taken together, these results suggest, for the first time, that targeting the overproduction of endothelial ONOO − can regulate cisplatin-induced neurotoxicity through neuronal caspase-1, and thereby serve as a potential therapeutic approach to alleviate chemotherapy-induced anorexia and weight loss.

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“…However, NBDNO derivatives were highly sensitive to reducing agents in previous reports. [15] Moreover, PNO micelles were stable under 700 nm light irradiation in the absence of SNB (Figure S31).…”

Section: Nir-mediated Onoo à Release In Aqueous Solutionsmentioning

confidence: 99%

Overcoming the Oxygen Dilemma in Photoredox Catalysis: Near‐Infrared (NIR) Light‐Triggered Peroxynitrite Generation for Antibacterial Applications

et al. 2023

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The peroxynitrite anion (ONOO−) is closely associated with many diseases and the creation of ONOO− donors is an essential means of understanding its pathophysiological functions. However, it is challenging to develop ONOO− donors due to the difficulties in simultaneously producing highly reactive and short‐lived nitric oxide (NO) and superoxide anion (O2⋅−). Here, we report a novel strategy for constructing ONOO− donors by combining near‐infrared (NIR)‐mediated type I photosensitization and photoredox catalysis. The key design using a Nile blue analogue that can serve as both a type I photosensitizer and a metal‐free photocatalyst. Intriguingly, the formation of O2⋅− via type I photosensitization avoids oxygen interference and instead activates nitrobenzofurazan‐based NO donors via oxygen‐tolerant NIR photoredox catalysis. The simultaneous release of O2⋅− and NO leads to ONOO− release, showing both antibacterial and antibiofilm activities.

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One-electron reduction triggered nitric oxide release for ischemia-reperfusion protection

Cited by 6 publications

References 54 publications

Photo-controlled and photo-calibrated nanoparticle enabled nitric oxide release for anti-bacterial and anti-biofilm applications

Photo-controlled and photo-calibrated nanoparticle enabled nitric oxide release for anti-bacterial and anti-biofilm applications

Endothelial peroxynitrite causes disturbance of neuronal oscillations by targeting caspase-1 in the arcuate nucleus

Overcoming the Oxygen Dilemma in Photoredox Catalysis: Near‐Infrared (NIR) Light‐Triggered Peroxynitrite Generation for Antibacterial Applications

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