One-Day Session LINAC–Based Stereotactic Radiosurgery of Posterior Uveal Melanoma

Furdová, Alena; Strmeň, P.; Waczulı́ková, Iveta; Chorváth, Martin; Šramka, M; Slezák, Peter

doi:10.5301/ejo.2011.7733

Cited by 24 publications

(23 citation statements)

References 32 publications

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“…Historically, melanoma has been considered a radioresistant tumor, but newer data have challenged this viewpoint. According to our results, a single one-day sessions SRS with 35.0 Gy is suffi cient to treat small and middle stage melanoma (8).…”

Section: B Amentioning

confidence: 69%

“…Based on tumor staging (I, II, III, and IV), features that showed a signifi cant increase with tumor staging included the age at presentation (57, 58, 60, 60 years) (p < 0.001), tumor base (8,12,17,17 mm) (p < 0.001), tumor thickness (2.9, 6.0, 10.1, 10.2 mm) (p < 0.001), distance to optic disc (3, 5, 5, 5 mm) (p < 0.001), distance to foveola (3, 5, 5, 5 mm) (p < 0.001), mushroom confi guration (6 %, 24 %, 34 %, 33 %) (p < 0.001), plateau confi guration (3 %, 4 %, 7 %, 11 %) (p < 0.001), tumor pigmentation (48 %, 53 %, 69 %, 78 %) (p < 0.001), and extraocular extension (0 %, 1 %, 11 %, 22 %) (p < 0.001). After therapy, Kaplan-Meier estimates of metastasis at 1, 5, 10, and 20 years were < 1 %, 5 %, 12 %, and 20 % for stage I, 2 %; 17 %, 29 %, and 44 % for stage II; 6 %, 44 %, 61 %, and 73 % for stage III, and 100 % by 1 year for stage IV.…”

Section: B Amentioning

confidence: 99%

“…According to the Slovak National Cancer Registry, the incidence in Slovakia is 0.2 to 0.6 / 100 000 inhabitants. Choroidal malignant melanoma is the most frequent uveal melanoma -over 75 % (8).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is it sufficient to repeat LINEAR accelerator stereotactic radiosurgery in choroidal melanoma?

Furdová¹,

Horkovičová²,

Justusova³

et al. 2016

BLL

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OBJECTIVES: One day session LINAC based stereotactic radiosurgery (SRS) at LINAC accelerator is a method of "conservative" attitude to treat the intraocular malignant uveal melanoma. METHODS: We used model Clinac 600 C/D Varian (system Aria, planning system Corvus version 6.2 verifi cation IMRT OmniPro) with 6 MeV X by rigid immobilization of the eye to the Leibinger frame. The stereotactic treatment planning after fusion of CT and MRI was optimized according to the critical structures (lens, optic nerve, also lens and optic nerve at the contralateral side, chiasm). The fi rst plan was compared and the best plan was applied for therapy at C LINAC accelerator. The planned therapeutic dose was 35.0 Gy by 99 % of DVH (dose volume histogram). RESULTS: In our clinical study in the group of 125 patients with posterior uveal melanoma treated with SRS, in 2 patients (1.6 %) was repeated SRS indicated. Patient age of the whole group ranged from 25 to 81 years with a median of 54 TD was 35.0 Gy. In 2 patients after 5 year interval after stereotactic radiosurgery for uveal melanoma stage T1, the tumor volume increased to 50 % of the primary tumor volume and repeated SRS was necessary. CONCLUSION: To fi nd out the changes in melanoma characteristics after SRS in long term interval after irradiation is necessary to follow up the patient by an ophthalmologist regularly. One step LINAC based stereotactic radiosurgery with a single dose 35.0 Gy is one of treatment options to treat T1 to T3 stage posterior uveal melanoma and to preserve the eye globe. In some cases it is possible to repeat the SRS after more than 5 year interval (Fig. 8, Ref. 23). Text in PDF www.elis.sk.

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Section: B Amentioning

confidence: 69%

Section: B Amentioning

confidence: 99%

See 1 more Smart Citation

Is it sufficient to repeat LINEAR accelerator stereotactic radiosurgery in choroidal melanoma?

Furdová¹,

Horkovičová²,

Justusova³

et al. 2016

BLL

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“…Stereotactic radiosurgery has recently been proposed as an alternative treatment for posterior uveal melanoma. Secondary infi ltration of the conjunctiva after radiotherapy due to scleral infi ltration is very rare (19,20,21).…”

Section: Discussionmentioning

confidence: 99%

Therapy of melanocytic conjunctival tumors

Halas¹,

Svetlosakova²,

Babál³

2013

BLL

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Abstract:Background: Clinical experience of our single center in dealing with pigmented epibulbar lesionsmelanocytic conjunctival tumors is presented. Since 2008 we use the topical treatment with mitomycin C (MMC) as an alternative or adjunctive method for excision in the treatment of melanocytic neoplasia of the conjunctiva. Methods: The retrospective case series of 85 patients with pigmented lesions of the conjunctiva -melanocytic conjunctival tumors, histopathologically examined in the period 2001-2010 is presented. Since 2008 we started to apply MMC in the treatment of primary acquired melanosis (PAM) and dysplastic nevi. We apply MMC topically directly after an excision as 2-times fi ve minutes application. Results: In 85 patients with pigmented lesions of the conjunctiva histopathological fi ndings after excision of the lesion showed in 68 (80 %) cases melanocytic nevocelullar nevus, out of which 55 cases were combined and 13 cases were junctional nevi. In 60 (80 %) cases of melanocytic nevi atypia was found in 25 patients (42 %), nevus without atypia was present in 35 cases (58 %). PAM with atypia was found in 16 patients (classifi ed since 2000). During the period of application of MMC we diagnosed only one patient with primary conjunctival melanoma. There was no presence of relapse of the pigmented lesion either after primary excision or after excision with MMC. Conclusion: Resection of more than one quadrant of bulbar conjunctiva in patients with pigmented lesions of the conjunctiva in cases of conjunctival nevus with atypia and PAM with atypia combined with topical MMC chemotherapy is an alternative therapy for residual pigmented lesions. There was no presence of relapse of pigmentation in area of excision with or without using MMC during the surgery in patients with PAM. The number of our patients is not suffi cient yet to draw a conclusion (Fig. 6, Ref. 21). Full Text in PDF www.elis.sk.

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“…Exact planning is very important in determining the stereotactic coordinates of radiation beams that apply into targeted tumor mass. Irradiation of critical structures by inappropriate doses can lead to loss of vision or other complications, and it can reduce quality of life after the therapy [6].…”

Section: Introductionmentioning

confidence: 99%

Options of Irradiating Intraocular Melanoma at Linear Accelerator: A Mini Review

Justusova¹

2017

AOVS

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One-Day Session LINAC–Based Stereotactic Radiosurgery of Posterior Uveal Melanoma

Abstract: One-step LINAC-based SRS with a single dose 35.0 Gy is a method to treat middle-stage posterior uveal melanoma and to preserve the eye globe or as the first step of combined methods: irradiation before endoresection or cyclectomy.

Cited by 24 publications

References 32 publications

Is it sufficient to repeat LINEAR accelerator stereotactic radiosurgery in choroidal melanoma?

Is it sufficient to repeat LINEAR accelerator stereotactic radiosurgery in choroidal melanoma?

Therapy of melanocytic conjunctival tumors

Options of Irradiating Intraocular Melanoma at Linear Accelerator: A Mini Review

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