One cell one niche: hematopoietic microenvironments constructed by bone marrow stromal cells with fibroblastic and histiocytic features

Ru, Yongxin; Dong, Shuang; Zhao, Shi-Xuan; Li, Yuan; Liang, Haoyue; Zhang, M M Fengkui; Zhu, Xiaofan; Zheng, Yizhou

doi:10.1080/01913123.2019.1620394

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…To observe proteolytic environment during HSC mobilization [111] Transwell migration assay Determines HSPC transmigration capacity and interaction between hematopoietic cells and their niche [112] In vitro dynamic phenotyping method Quantitative classification of mobilization agents and target specific inhibitors/treatments using dynamics of HSPC [113] Morphological features Construction of hematopoietic microenvironment [114] Live imaging technique of slice cultures, clonal analysis, and mathematical modeling Understanding origin and 3-D organization of niche in intra-aortic hematopoietic cluster formation [115] Zebrafish models have long been used for lineage tracing during embryonic stages, and recent genetic models have made that easier. For example, the lineage tracing of HSPCs from aortic hemogenic endothelium was performed using a multicolor transgenic labeling system called blood bow, along with high-end imaging and FACS.…”

Section: Molecular Technique Functional Exploration Referencesmentioning

confidence: 99%

“…The in vitro dynamic phenotyping method enables the classification of mobilization agents, and targets specific inhibitors/treatments quantitatively [113]. The hematopoietic microenvironment can also be constructed using morphological features using bone marrow granule samples and detailed images that illustrate hematopoietic cells with fibroblastic and histiocytic features [114].…”

Section: Molecular Technique Functional Exploration Referencesmentioning

confidence: 99%

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Hematopoietic Stem and Progenitor Cells (HSPCs) and Hematopoietic Microenvironment: Molecular and Bioinformatic Studies of the Zebrafish Models

Faisal

Hassan

Kumar

et al. 2022

IJMS

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Hematopoietic stem cells (HSCs) reside in a specialized microenvironment in a peculiar anatomic location which regulates the maintenance of stem cells and controls its functions. Recent scientific progress in experimental technologies have enabled the specific detection of epigenetic factors responsible for the maintenance and quiescence of the hematopoietic niche, which has improved our knowledge of regulatory mechanisms. The aberrant role of RNA-binding proteins and their impact on the disruption of stem cell biology have been reported by a number of recent studies. Despite recent modernization in hematopoietic microenvironment research avenues, our comprehension of the signaling mechanisms and interactive pathways responsible for integration of the hematopoietic niche is still limited. In the past few decades, zebrafish usage with regards to exploratory studies of the hematopoietic niche has expanded our knowledge for deeper understanding of novel cellular interactions. This review provides an update on the functional roles of different genetic and epigenetic factors and molecular signaling events at different sections of the hematopoietic microenvironment. The explorations of different molecular approaches and interventions of latest web-based tools being used are also outlined. This will help us to get more mechanistic insights and develop therapeutic options for the malignancies.

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Section: Molecular Technique Functional Exploration Referencesmentioning

confidence: 99%

Section: Molecular Technique Functional Exploration Referencesmentioning

confidence: 99%

Hematopoietic Stem and Progenitor Cells (HSPCs) and Hematopoietic Microenvironment: Molecular and Bioinformatic Studies of the Zebrafish Models

Faisal

Hassan

Kumar

et al. 2022

IJMS

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“…The microenvironment in the BM serves an important role in regulating hematopoiesis. BM stromal cells, endothelial cells (ecs), osteoblasts, macrophages, extracellular matrix and secreted cytokines form a honeycomb-like hematopoietic microenvironment (43,44). The destruction and dysfunction of ecs and BM mesenchymal stem cells (MScs) may alter the hematopoietic microenvironment (43,(45)(46)(47).…”

Section: Sars-cov-2 Destroys the Hematopoietic Microenvironmentmentioning

confidence: 99%

Hematological changes in patients with COVID‑19 (Review)

Jiao

Zhang

et al. 2020

Mol Med Rep

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in december 2019, an emergence of pneumonia was detected in patients infected with a novel coronavirus (coV) in Wuhan (Hubei, china). The international committee on Taxonomy of Viruses named the virus severe acute respiratory syndrome-coV-2 and the disease coV disease-19 (coVid-19). Patients with coVid-19 present with symptoms associated with respiratory system dysfunction and hematological changes, including lymphopenia, thrombocytopenia and coagulation disorders. However, to the best of our knowledge, the pathogenesis of coVid-19 remains unclear. Therefore, understanding the mechanisms underlying the hematological changes that manifest during coVid-19 may aid in the development of treatments and may improve patient prognosis. Contents1. introduction 2. Hematological changes in patients with coVid-19 3. Possible mechanisms of lymphopenia and thrombocytopenia in patients with coVid-19 4. Possible mechanisms involved in coagulation disorders in patients with coVid-19 5. Potential treatments 6. conclusions

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“…For the alternative regeneration mechanism, bloodborne cells of the bone marrow origin also play a role, in addition to the resident liver cells [11][12][13]. Hepatic stellate cells (HSCs) are also an important element of the liver regeneration machinery being part of liver stem cell niche, supporting regeneration at early stages by producing growth factors and inducing regeneration arrest after restoration of normal organ mass [14].…”

Section: General Mechanism Of Liver Regenerationmentioning

confidence: 99%

Liver regeneration in traditional Chinese medicine: advances and challenges

et al. 2020

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Liver diseases pose a serious problem for national health care system all over the world. Liver regeneration has profound impacts on the occurrence and development of various liver diseases, and it remains an extensively studied topic. Although current knowledge has suggested two major mechanisms for liver regeneration, including compensatory hyperplasia of hepatocytes and stem or progenitor cell-mediated regeneration, the complexity of this physiopathological process determines that its effective regulation cannot be achieved by single-target or single-component approaches. Alternatively, using traditional Chinese medicine (TCM) to regulate liver regeneration is an important strategy for prevention and treatment of liver disorder and the related diseases. From the perspectives of TCM, liver regeneration can be caused by the disrupted balance between hepatic damage and regenerative capacity, and the “marrow”-based approaches have important therapeutic implications for liver regeneration. These two points have been massively supported by a number of basic studies and clinical observations during recent decades. TCM has the advantages of overall dynamic fine-tuning and early adjustment, and has exhibited enormous therapeutic benefits for various liver diseases. Here, we review the recent advances in the understanding of liver regeneration in TCM system in the hope of facilitating the application of TCM for liver diseases via regulation of liver regeneration.

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One cell one niche: hematopoietic microenvironments constructed by bone marrow stromal cells with fibroblastic and histiocytic features

Cited by 4 publications

References 31 publications

Hematopoietic Stem and Progenitor Cells (HSPCs) and Hematopoietic Microenvironment: Molecular and Bioinformatic Studies of the Zebrafish Models

Hematopoietic Stem and Progenitor Cells (HSPCs) and Hematopoietic Microenvironment: Molecular and Bioinformatic Studies of the Zebrafish Models

Hematological changes in patients with COVID‑19 (Review)

Liver regeneration in traditional Chinese medicine: advances and challenges

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