One- and Two-Dimensional Nuclear Magnetic Resonance Characterization of Poly(aspartic acid) Prepared by Thermal Polymerization of L-Aspartic Acid

Wolk, Steven K.; Swift, Graham; Paik, Yi Hyon; Yocom, Kathryn M.; Smith, Rebecca L.; Simon, Ethan S.

doi:10.1021/ma00104a016

Cited by 109 publications

(106 citation statements)

References 8 publications

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“…Earlier structural analyses demonstrated that β-Asp units account for 70 % of the total composition of tPAA, indicating that tPAA is composed of a high proportion of β-peptides. The analyses also showed that tPAA contains equivalent moles of D-and L-Asp units, with branching and cross-linking as unnatural structures, in addition to β-Asp units [45][46][47][48][49]. As unnatural structures in polymer materials generally affect the biodegradability of the material, tPAA biodegradability should be carefully considered in its applications.…”

Section: Paamentioning

confidence: 99%

Biodegradable Polymers: Recent Developments and New Perspectives

Carrasco¹,

Pérez²,

Cailloux³

et al. 2017

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Section: Paamentioning

confidence: 99%

Biodegradable Polymers: Recent Developments and New Perspectives

Carrasco¹,

Pérez²,

Cailloux³

et al. 2017

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“…The reaction yields a melt which is difficult to handle. In NMR and biodegradation studies, these polyaspartates showed less branching and improved biodegradability compared to those prepared without an acid catalyst [31][32][33] (see Chapter 4). In addition, these polyaspartates have a higher molecular mass of approximately 50 000.…”

Section: Solid-phase Thermal Polycondensationmentioning

confidence: 99%

Polyaspartates and Polysuccinimide

Klein

Moritz

Graupner

2008

Ullmann's Encyclopedia of Industrial Chemistry

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The article contains sections titled: 1. Introduction 2. Synthesis and Production of Polyaspartates 3. Analytical Characterization and Detection 3.1. NMR Spectroscopy 3.2. NMR Spectroscopy 3.3. Gel Permeation Chromatography 3.4. Isotachophoresis 3.5. Fluorescence Spectroscopy 3.6. Precipitation Titration 3.7. Polyelectrolyte Titration 4. Toxicological Properties and Environmental Fate 5. Function and Applications 5.1. Functionality 5.1.1. Dispersing Effect 5.1.2. Threshold Effect 5.1.3. Crystal Distortion 5.1.4. Complexing Effect 5.1.5. Corrosion Inhibition 5.2. Applications and Uses of Polyaspartates 5.2.1. Water Treatment 5.2.2. Detergents and Cleaners 5.2.3. Mining and Oil Recovery 5.2.4. Other Uses 6. Polysuccinimide 6.1. Introduction 6.2. Chemical Properties and Analytic Characterization 6.3. Applications and Uses of Polysuccinimide 7. References Polyaspartates are biodegrable polyanions which can substitute the currently used polycarboxylates or polyacrylates as inhibitors of mineral formation and scaling, widely occurring problems in various industrial processes. Polyaspartates can be used in many applications such as detergents and cleaners, water treatment agents, or as agents in mining and oil recovery. Production in commercial scale is possible by polycondensation of enzymatically produced l ‐aspartic acid. However, complete substitution of polycarboxylates, which are mainly non‐biodegradable, would only be possible by using chemical precursors of aspartic acid. Polyaspartates have excellent toxicological properties.

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“…In the present study, we reported the acid catalyst polycondensation of aspartic acid with valine product poly-(aspartamide/valine) (PAV) at different molar ratios. Their chemical structures were conformed by 13 C-NMR, DSC, FT-IR, X-ray, and GPC measurements. The effects of light, temperature, humidity, and pH on PHPAV were investigated.…”

Section: Introductionmentioning

confidence: 99%

Biodegradation of poly(L‐aspartic acid‐co‐valine) and its derivatives

Tang

He²

2006

J of Applied Polymer Sci

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Biodegradable poly(l-aspartic-acid/valine) (PAV) was synthesized by thermal polycondensation. The molar ratios of aspartic acid/valine were 9 : 1, 8 : 2, 7 : 3, 6 : 4, and 5 : 5, respectively. The chemical structure of PAV was confirmed by 13 C-NMR, DSC, FTIR, X-ray, and GPC measurements. The degradation of PAV was studied in PBS buffer solution (pH 7.4 and 8.2) and in aqueous solution with enzymatic hydrolysis in which papain and trypsine acted as catalyst. It showed that the biodegradation rate of PAV was increased when the content of valine in copolymer increased. 3-Hydroproplamine was used in a succinimide ring-open reaction to obtain hydrophilic products (PHPAV).Stability tests showed that humidity, light, and temperature had no remarkable effect on PHPAV, however, it could be degraded in base solution. Biocompatibility and hematological tests were investigated. No deaths were found in the mice treated with PHPAV solution up to a 7.5 g/kg dose. No differences in number of red cells and glutamic pyruvic and creatinuria transaminase activities were found between the experiment and the control groups.

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One- and Two-Dimensional Nuclear Magnetic Resonance Characterization of Poly(aspartic acid) Prepared by Thermal Polymerization of L-Aspartic Acid

Cited by 109 publications

References 8 publications

Biodegradable Polymers: Recent Developments and New Perspectives

Biodegradable Polymers: Recent Developments and New Perspectives

Polyaspartates and Polysuccinimide

Biodegradation of poly(L‐aspartic acid‐co‐valine) and its derivatives

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