One Anastomosis Gastric Bypass in the Treatment of Obesity: Effects on Body Weight and the Metabolome

Mika, Adriana; Śledziński, Tomasz; Proczko-Stepaniak, Monika; Magkos, Faidon

doi:10.1007/978-3-030-53370-0_58

Cited by 2 publications

(1 citation statement)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is also a small number of studies that showed changes in oxylipins pro le after bariatric intervention (Modesitt et al, 2015;Sarosiek et al, 2016;Schulte et al, 2020a). Considering the regulatory effects of oxylipins, it is possible that they in uence the emergence of positive metabolic changes that are observed after bariatric surgery (Mika et al, 2020;Ji et al, 2021;Vrakopoulou et al, 2021;van Veldhuisen et al, 2022). Determining how a speci c bariatric procedure affects the oxylipins pro le can therefore provide insight into possible mechanisms that lead to metabolically advantageous outcomes.…”

Section: Introductionmentioning

confidence: 99%

Changes in serum oxylipin profile after one anastomosis gastric bypass

Pakiet

Łukaszewicz

Proczko-Stepaniak

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

The bioactive oxylipins are important compounds in the chronic inflammation-associated conditions, such as obesity. Treatment of obesity with bariatric surgery improves metabolic state of the patients, thus, the study of oxylipins can provide insight into how the metabolic states of patients changes after the procedure. We determined the free oxylipins profile in serum of 15 patients that underwent one-anastomosis gastric bypass (OAGB) before the surgery, two weeks and 6–9 months after the surgery. For this purpose, a liquid chromatography-tandem mass spectrometry (LC-MS/MS), with solid-phase extraction (SPE) method was validated for the quantification of 27 oxylipins. The analytical method was characterized by good linearity (regression coefficient > 0.99), detection limits from 2 pg to 394 pg. The mean precision was ~ 101%, accuracy was ~ 12% and extraction efficiency for most analytes ranged between 80–120%. In patients serum samples at 6–9 months the oxylipin profiles differed significantly from other time points, mostly with regards to oxylipins associated with endothelial function. Our study demonstrates the value in oxylipin profiling to monitor the metabolic effects of obesity treatment.

show abstract