Ondansetron versus Amitriptyline in the Treatment of Peripheral Neuropathy: A Randomized Double Blind Prospective Clinical Study

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“…5 The results of our study in case of Gabapentin group are similar to studies conducted earlier in which Gabapentin showed significant improvement in nerve conduction. 12,13 However in contrast to some studies 12,14 , where no significant improvement in NCV was shown by Amitriptyline, our study reported significant improvement in NCV in Amitriptyline group as well. The results in case of Amitriptyline group differed from these studies 12,14 as in our study significant improvement in NCV was shown in Amitriptyline group, this can be attributed to significant glycemic control during the study duration.…”

“…12,13 However in contrast to some studies 12,14 , where no significant improvement in NCV was shown by Amitriptyline, our study reported significant improvement in NCV in Amitriptyline group as well. The results in case of Amitriptyline group differed from these studies 12,14 as in our study significant improvement in NCV was shown in Amitriptyline group, this can be attributed to significant glycemic control during the study duration. There exists a strong evidence in published literature that glycemic control prevents deterioration in nerve conduction.…”

“…Also NCV in Amitriptyline group demonstrated worsening in one of the parameters, Fwaves, in left tibial nerve. 14 In contrast, our study had shown a statistically significant improvement in sensory NCV in Amitriptyline group. In a study conducted by Rajesh M et al in 2015, comparison of pre-drug (0 week) and post-drug (12th week) values showed significant improvement in both latency and conduction velocity in the Pregabalin and Gabapentin treated groups, in both motor and sensory nerves.…”