Ondansetron should never be used in pregnancy: AGAINST

Damkier, Per; Kaplan, Yusuf Cem; Shechtman, Svetlana; Diav–Citrin, Orna; Cassina, Matteo; Weber-Schoendorfer, Corinna; Cleary, Brian; Hodson, Kenneth

doi:10.22541/au.159493191.15147187

Cited by 2 publications

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“…In their study, Damkier et al showed that ondansetron used in the first trimester of pregnancy did not increase the risk of cardiac malformation and that the oral cleft palate risk was only three for every 10,000 liveborn children exposed to ondansetron [15].…”

Section: Discussionmentioning

confidence: 97%

Effect of ondansetron application on neural tube development in 48-hour chick embryos

2021

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The study aims to show that ondansetron, which is used safely in pregnant women, can cause serious side effects. Neural tube defects are among the most common congenital malformations of the central nervous system. It is known that genetic predisposition, environmental factors, and some drugs play an important role in the development of neural tube defects. Ondansetron is a selective 5-hydroxytryptamine-3 receptor antagonist used in the treatment of cancer, nausea, and vomiting during pregnancy and after anesthesia. In the literature studies, it was not found that developmental anomalies were observed. Seventy-five free specific pathogen eggs were incubated for 32 hours and divided into five groups of 15 eggs each, including a control group. Ondansetron was administered to these five groups by sub-blastoderm route in 4 different doses with a Hamilton microinjector. At 48 hours of incubation, the embryos were dissected and examined morphologically and histopathologically. At the end of the study, a significant dose-dependent decrease was observed in crown-rump lengths, somite numbers, and mean the number of silver-dyed nucleolar regulatory regions (AgNOR) and total AgNOR / nuclear area ratios. Statistically significant differences were observed between the experimental groups in terms of neural tube closure (p <0.05). Ondansetron has been shown to affect neuronal development and vertebral growth in chicken embryos depending on increasing doses.

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Section: Discussionmentioning

confidence: 97%

Effect of ondansetron application on neural tube development in 48-hour chick embryos

2021

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“…Furthermore, this opinion is also shared by other experts in pre-and postnatal vigilance who are members of the European Network of Teratology Information Services. 17 In practice, it seems reasonable to consider prescribing ondansetron to a pregnant woman with severe pregnancy-induced vomiting if first-line treatments, such as doxylamine alone or in combination with vitamin B6 or metoclopramide, have failed, and especially after week ten of pregnancy. 18 Although it may be preferable not to use ondansetron before week ten, as a precautionary measure, exposure before this time should, nevertheless, not lead to the patient being worried: at most, good-quality ultrasound monitoring of the fetus targeted at the facial mass may be considered in principle.…”

Section: Introductionmentioning

confidence: 99%

5-HT3 Antagonist for Pregnancy Associated Nausea and Vomiting

Ghosh¹,

Dev²,

Matthews³

2021

IHRJ

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5-HT3 antagonists appear to be an effective treatment option in the treatment of nausea and vomiting associated with pregnancy. Literature suggests an increased risk of congenital defects in fetuses exposed to ondansetron during pregnancy, especially during first trimester. Health authorities now suggest that this drug should not be used during this period. However, this decision is debatable and whether ondansetron can be used in pregnant women is still controversial.

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Ondansetron should never be used in pregnancy: AGAINST

Cited by 2 publications

References 0 publications

Effect of ondansetron application on neural tube development in 48-hour chick embryos

Effect of ondansetron application on neural tube development in 48-hour chick embryos

5-HT3 Antagonist for Pregnancy Associated Nausea and Vomiting

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