Ondansetron serum concentration and polymorphisms of CYP2D6, ABCB1 and 5-HT3B receptor genes in the treatment of chemoterapy induced nausea and vomiting
Abstract:This study was aimed to understand differences of ondansetron serum concentration in each antiemetic responses, polymorphisms of 5HT3B receptor, CYP2D6 and ABCB1 genes in Indonesian cancer patients treated with high emetogenic cytostatics. We recruited cancer patients in Dr Sardjito Hospital treated with cisplatin (≥ 50 mg/m 2 ) as monotherapy or combination therapy. Patients were treated with ondansetron 8 mg intravenously and dexamethasone 8 mg intravenously and metoclopramide (10 mg orally) after cytostatic… Show more
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