Ondansetron prevents postoperative emesis in male outpatients

Kovac, Anthony L.; Pearman, Michael H.; Khalil, Sara; Scuderi, Phillip E.; Joslyn, Alan F.; Prillaman, Barbara A.; Cox, Felicia

doi:10.1016/s0952-8180(96)00173-0

Cited by 31 publications

(20 citation statements)

References 25 publications

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“…Ironically, while writing this manuscript a report of yet another large multicentre trial of ondansetron appeared in a peer reviewed journal 47. It contained the same data as a report published two years earlier 23.…”

Section: Methodsmentioning

confidence: 87%

Impact of covert duplicate publication on meta-analysis: a case study

Tramèr

Reynolds²,

Moore³

et al. 1997

BMJ

627

328

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Section: Methodsmentioning

confidence: 87%

Impact of covert duplicate publication on meta-analysis: a case study

Tramèr

Reynolds²,

Moore³

et al. 1997

BMJ

627

328

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show abstract

“…The network meta-analysis for delirium included 18 studies involving 3,652 patients in which ondansetron, granisetron, dolasetron, tropisetron, and dolasetron plus dexamethasone were administered during surgery [52, 60, 68, 69, 76, 79, 96, 100, 105, 106, 118, 124, 128, 133, 137, 139, 144, 146]. The network geometry and included drugs can be found in Fig.…”

Section: Resultsmentioning

confidence: 99%

Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

Tricco

Soobiah

Blondal

et al. 2015

BMC Med

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BackgroundSerotonin (5-HT3) receptor antagonists are commonly used to decrease nausea and vomiting for surgery patients, but these agents may be harmful. We conducted a systematic review on the comparative safety of 5-HT3 receptor antagonists.MethodsSearches were done in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify studies comparing 5-HT3 receptor antagonists with each other, placebo, and/or other antiemetic agents for patients undergoing surgical procedures. Screening search results, data abstraction, and risk of bias assessment were conducted by two reviewers independently. Random-effects pairwise meta-analysis and network meta-analysis (NMA) were conducted. PROSPERO registry number: CRD42013003564.ResultsOverall, 120 studies and 27,787 patients were included after screening of 7,608 citations and 1,014 full-text articles. Significantly more patients receiving granisetron plus dexamethasone experienced an arrhythmia relative to placebo (odds ratio (OR) 2.96, 95 % confidence interval (CI) 1.11–7.94), ondansetron (OR 3.23, 95 % CI 1.17–8.95), dolasetron (OR 4.37, 95 % CI 1.51–12.62), tropisetron (OR 3.27, 95 % CI 1.02–10.43), and ondansetron plus dexamethasone (OR 5.75, 95 % CI 1.71–19.34) in a NMA including 31 randomized clinical trials (RCTs) and 6,623 patients of all ages. No statistically significant differences in delirium frequency were observed across all treatment comparisons in a NMA including 18 RCTs and 3,652 patients.ConclusionGranisetron plus dexamethasone increases the risk of arrhythmia.Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-015-0379-3) contains supplementary material, which is available to authorized users.

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“…In a male-only study by Kovac et al [120], ondansetron 4 mg IV administered prior to the induction of outpatient anesthesia was determined to be an effective dose for PONV prevention. In children older than 2 years, 0.1 mg/kg orally was effective for prevention [121] and 0.1 mg/kg (Ͻ40 kg) and 4 mg (Ն40 kg) IV for treatment [122].…”

Section: Ondansetronmentioning

confidence: 99%

“…Initially the PONV prevention studies [117,120] with IV ondansetron were administered prior to the start of anesthesia. Sun et al [123] and Tang et al [124] investigated ondansetron's PONV efficacy when administered at the end of surgery.…”

Section: Ondansetronmentioning

confidence: 99%

Prevention and Treatment of Postoperative Nausea and Vomiting

Kovac¹

2003

Antiemetic Therapy

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Ondansetron prevents postoperative emesis in male outpatients

Cited by 31 publications

References 25 publications

Impact of covert duplicate publication on meta-analysis: a case study

Impact of covert duplicate publication on meta-analysis: a case study

Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

Prevention and Treatment of Postoperative Nausea and Vomiting

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