Ondansetron-induced ventricular tachycardia in a patient of caesarian section

Supraventricular Tachycardia Associated With Ondansetron

“…A case of pulseless VT requiring CPR has been reported following ondansetron administration intraoperatively, on a ground of hypomagnesemia and hypokalemia, which was successfully managed, 4 whereas another case of VT required cardioconversion to return to sinus rhythm. 5 Another arrythmia associated with ondansetron has been atrial fibrillation, with Kasinath et al reporting a case who finally needed pharmaceutical treatment and surveillance, 6 while Havrilla et al a case developing ST segment alterations on top of atrial fibrillation onset. 7 Both cases had unremarkable previous medical history and the arrythmia was manifested after a second ondansetron dosage.…”

“…A case of pulseless VT requiring CPR has been reported following ondansetron administration intraoperatively, on a ground of hypomagnesemia and hypokalemia, which was successfully managed, 4 whereas another case of VT required cardioconversion to return to sinus rhythm. 5…”

Intraoperative pulseless ventricular tachycardia after Ondansetron

“…Prolongation of QRS or QT interval has been reported with granisetron, ondansteron, and dolasetron leading to ventricular tachyarrhythmias though not commonly in healthy population. [ 4 ] Molecular level affinity of ondansetron to human tissue by human ether-a-go-go-related gene (HERG) programmed K + channel lead to prolongation of cardiac repolarization and QT prolongation. [ 5 ] In our case ondansetron induced QT prolongation triggered by electrolyte disturbances thereby leading to pulseless VT.…”