Ondansetron, dexamethasone and an NK1 antagonist block radiation sickness in mice

Yamamoto, Kouichi; Nohara, Kyoko; Furuya, T; Yamatodani, Atsushi

doi:10.1016/j.pbb.2005.07.007

Cited by 17 publications

(7 citation statements)

References 37 publications

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“…The main aetiology of the behaviour has been considered to supply essential mineral substances (zinc, calcium, and iron) by eating materials (Halsted, ); however, a previous report suggested that pica played a role in the detoxification of toxins or elimination of gastrointestinal discomfort by ingesting soil (Johns and Duquette, ). We reported that pica in rats and mice was induced by emetic stimuli and inhibited by a pretreatment with the respective anti‐emetic agents (Yamamoto et al ., 2004; 2005). Furthermore, as we demonstrated that the incidence, latency and duration of chemotherapeutic drug‐induced pica are related to the clinical emetogenicity of these drugs (Yamamoto et al ., 2007; 2011), pica is useful for assessing the emetogenic potential or anti‐emetic efficacy of newly developed drugs in preclinical studies.…”

Section: Resultsmentioning

confidence: 99%

Involvement of substance P in the development of cisplatin‐induced acute and delayed pica in rats

Yamamoto

Asano

Tasaka

et al. 2014

British J Pharmacology

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BACKGROUND AND PURPOSEAlthough substance P (SP) and neurokinin NK1 receptors have been reported to be involved in cisplatin-induced acute and delayed emesis, their precise roles remain unclear. Pica, the consumption of non-nutrient materials such as kaolin in rats, can be used as a model of nausea in humans. We investigated the time-dependent changes in cisplatin-induced pica and the involvement of SP and NK1 receptors in this behaviour. EXPERIMENTAL APPROACHRats were administered cisplatin with or without a daily injection of a 5-HT3 receptor antagonist (granisetron) or an NK1 receptor antagonist (aprepitant), and kaolin intake was then monitored for 5 days. The effects of granisetron on the cisplatin-induced expression of preprotachykinin-A (PPT-A) mRNA, which encodes mainly for SP, and on SP release in the medulla, measured by in vivo brain microdialysis, were also investigated. KEY RESULTSCisplatin induced pica within 8 h of its administration that continued for 5 days. Granisetron inhibited the acute phase (day 1), but not the delayed phase (days 2-5), of pica, whereas aprepitant abolished both phases. Within 24 h of the injection of cisplatin, PPT-A mRNA expression and SP release in the medulla were significantly increased; these findings lasted during the observation period and were inhibited by granisetron for up to 24 h. CONCLUSIONS AND IMPLICATIONSThe profiles of cisplatin-induced pica in rats are similar to clinical findings for cisplatin-induced emesis in humans, and we showed that SP production in the medulla and activation of NK1 receptors are involved in this cisplatin-induced pica. Abbreviations

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Section: Resultsmentioning

confidence: 99%

Involvement of substance P in the development of cisplatin‐induced acute and delayed pica in rats

Yamamoto

Asano

Tasaka

et al. 2014

British J Pharmacology

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“…So far, neither aprepitant nor casopitant have been formally tested for patients with radiation-induced nausea and vomiting in a randomized trial and can therefore not be recommended, although the pathogenesis of RINV is thought to be mediated in parts by substance P [47].…”

Section: Prophylaxis With Neurokinin-1 Receptor Antagonistsmentioning

confidence: 99%

Radiotherapy-induced nausea and vomiting (RINV): MASCC/ESMO guideline for antiemetics in radiotherapy: update 2009

Feyer

Maranzano

Molassiotis

et al. 2010

Support Care Cancer

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Radiation-induced nausea and vomiting (RINV) are still often underestimated by radiation oncologists. However, as many as 50-80% of patients undergoing radiotherapy (RT) will experience nausea and/or vomiting, depending on the site of irradiation. Fractionated RT may involve up to 40 fractions over a 6-8-week period, and prolonged symptoms of nausea and vomiting affect quality of life. Furthermore, uncontrolled nausea and vomiting may result in patients delaying or refusing further radiotherapy. Incidence and severity of nausea and vomiting depend on RT-related factors (irradiated site, single and total dose, fractionation, irradiated volume, radiotherapy techniques) and patient-related factors (gender, general health of the patient, age, concurrent or recent chemotherapy, psychological state, tumor stage). The new proposed guideline from the Multinational Association of Supportive Care in Cancer and European Society of Clinical Oncology summarises the updated data from the literature and takes into consideration the existing guidelines. According to the irradiated area (the most frequently studied risk factor), the proposed guideline divided these areas into four levels of emetogenic risk: high, moderate, low and minimal. In fact, the emetogenicity of radiotherapy regimens and recommendations for the appropriate use of antiemetics including 5-hydroxytryptamine receptor antagonists and steroids are given in regard to the applied radiotherapy or radiochemotherapy regimen. This updated guideline offers guidance to the treating physicians for effective antiemetic therapies in RINV.

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“…Several other attempts to estimate drug-induced nausea and emesis in rodents have been reported previously (Mitchell et al, 1976;Yamamoto et al, 2005Yamamoto et al, , 2007Malik et al, 2007), but the methods need care. For example, pica behavior, the eating of non-nutritive substances such as kaolin, is known to evaluate emetic potential in rodents (Yamamoto et al, 2007).…”

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confidence: 99%

Solid gastric emptying mediated by the serotonin (5-HT)3 receptor in mice is a simple marker to predict emesis

Ando

Takagi²

2011

J. Toxicol. Sci.

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Ondansetron, dexamethasone and an NK1 antagonist block radiation sickness in mice

Cited by 17 publications

References 37 publications

Involvement of substance P in the development of cisplatin‐induced acute and delayed pica in rats

Involvement of substance P in the development of cisplatin‐induced acute and delayed pica in rats

Radiotherapy-induced nausea and vomiting (RINV): MASCC/ESMO guideline for antiemetics in radiotherapy: update 2009

Solid gastric emptying mediated by the serotonin (5-HT)3 receptor in mice is a simple marker to predict emesis

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