Ondansetron and Granisetron for Prevention of Postoperative Nausea and Vomiting following Laparoscopic Cholecystectomy

Abstract

Introduction: Laparoscopic surgeries are known to be associated with a higher incidence of postoperative nausea and vomiting (PONV). Prophylaxis of PONV is usually achieved with a singledose antiemetic drug administered during the surgical procedure. The aim of this study was to compare the antiemetic efficacy of two different 5-hydroxytryptamine-3 (5HT3) receptor antagonists, ondansetron and granisetron when given prophylactically to patients undergoing laparoscopic cholecystectomy.Methods: It was a randomized, double blind study, conducted in 90 patients. Patients were divided into two groups: Group A and Group B with 45 patients in each group. Patients in groupA were given 100 microgram/kg ondansetron intravenously (IV), and patients in Group B were given 40 microgram/kg granisetron. Both the drugs were diluted in 10 ml of 0.9% NaCl and were given at the end of surgery. The standard general anesthetic technique was administered to all the patients. Episodes of nausea, retching and vomiting were assessed during the first 24 hours after anesthesia. results:There was no statistically significant difference for demographic data and duration of surgery among the two groups (P>0.05). Evaluated nausea and vomiting scores in the first 3 hours period revealed that each of the drugs had a similar antiemetic effect (P>0.05). Between 4-12 hours also the episodes of nausea, retching as well as vomiting were statistically insignificant in both the groups. In the last 12 hours, episodes of nausea, retching and vomiting were significantly higher in ondansetron group. conclusions: Granisetron, when given prophylactically, resulted in a significantly lower incidence of PONV than ondansetron in the first 24 hours.

The effect of intravenous dextrose administration for prevention of post-operative nausea and vomiting after laparoscopic cholecystectomy: A double-blind, randomised controlled trial

“…As a common substitute for traditional open cholecystectomy, LC has been introduced in cholelithiasis management; however, the evidence shows excessive episodes of PONV after LC. [ 18 19 ] Many studies have been conducted to evaluate the efficacy of different antiemetic medications in preventing PONV after LC, with a variable success rate. Such medication may also be problematic in terms of side effects including hypotension, dysphoria, excessive sedation, hallucination and dry mouth.…”

Comparison of Ondansetron and Granisetron Effects for Prevention of Nausea and Vomiting Following Strabismus Surgery

“…Gauchan et al evaluated the antiemetic efficacy of Ondansetron and Granisetron in patients undergoing laparoscopic cholecystectomy during the first 24 hours after anaesthesia. They indicated that Granisetron was effectively capable of increasing incidence of PONV as compared to Ondansetron in the first 24 hours [17].…”

“…Considering the maximum sample size, the standard deviation in similar studies, alpha coefficient of 5% and power of 80% [16], [17], 120 patients with strabismus surgery were randomly assigned to 3 groups of 40 subjects in the placebo, Ondansetron and Granisetron. Inclusion criteria: 1) Patients undergoing strabismus surgery over the age of 3 years And 2) Class 1 & 2 American Society of Anaesthesiologists' (ASA) classification of Physical Health.…”

Evaluating the Effect of Intraoperative Dextrose 10% Administration on Reducing Postoperative Nausea and Vomiting after Laparoscopic Surgery

“…Laparoscopic cholecystectomy is considered now a better substitution for traditional open cholecystectomy in patients suffering from cholecystitis; Unfortunately, Laparoscopic surgeries proved to show excessive episodes of PONV [16] with an incidence of approximately 30% [3,4]. Although many different antiemetic drugs in many studies have been evaluated rather alone or with combination trying to prevent PONV after LC, unsatisfactory results occurred.…”