Ondansetron, a selective 5-HT3 antagonist, antagonizes methamphetamine-induced anorexia in mice

Ginawi, O. T.; Al-Majed, Abdulhakeem A.; Al-Suwailem, A.

doi:10.1016/j.phrs.2004.09.002

Cited by 13 publications

(8 citation statements)

References 24 publications

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“…2001; Jaehne, Salem & Irvine 2005). In animal models, the structurally related psychostimulants MDMA and METH have been shown to cause a number of deleterious effects on brain and body including neurotoxicity, hyperthermia and anorexia (Dafters 1995; Ginawi, Al‐Majed & Al‐Suwailem 2005b; Warren et al . 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Acute and chronic use of psychostimulants (such as MDMA and METH) has been shown to result in decreased appetite, reduced feeding behavior, and drug‐induced anorexia (Cho et al . 2001; Ginawi et al . 2005b).…”

Section: Introductionmentioning

confidence: 99%

“…1997). Rats that were given METH (2 mg/kg) by intraperitoneal (IP) injection exhibited significant reduction in food intake (Ginawi et al . 2005b)…”

Section: Introductionmentioning

confidence: 99%

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PRECLINICAL STUDY: Changes in leptin, ghrelin, growth hormone and neuropeptide‐Y after an acute model of MDMA and methamphetamine exposure in rats

Kobeissy¹,

Jeung²,

Warren³

et al. 2007

Addiction Biology

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Club drug abuse is a growing problem in the United States. Beyond addiction and toxicity are endocrine effects which are not well characterized. Specifically, the changes in appetite following exposure to drugs of abuse are an interesting but poorly understood phenomenon. Serum hormones such as leptin, ghrelin, growth hormone (GH), and neuropeptide-Y (NP-Y) are known to affect appetite, but have not been studied extensively with drugs of abuse. In this work, we examine the effects of club drugs 3,4-methylenedioxymethamphetamine (MDMA) (ecstasy) and methamphetamine (METH) (doses of 5, 20 and 40 mg/kg) on serum concentrations of these hormones in adult male Sprague-Dawley rats 6, 12, 24 and 48 hours after drug administration. In a dose-dependent manner, MDMA was shown to cause transient significant decreases in serum leptin and GH followed by a base line recovery after 24 hours. Conversely, serum ghrelin increased and normalized after 24 hours. Interestingly, serum NP-Y showed a steady decrease in both treatment of MDMA and METH at different time points and dosages. In humans, abuse of these drugs reduces eating. As evident from these data, acute administration of METH and MDMA had significant effects on different serum hormone levels involved in appetite regulation. Future studies should be performed to see how chronic, low dose drug administration would affect hormone levels and try to answer questions about the physiological mechanisms involved in the anorexic paradigm observed in drug use.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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PRECLINICAL STUDY: Changes in leptin, ghrelin, growth hormone and neuropeptide‐Y after an acute model of MDMA and methamphetamine exposure in rats

Kobeissy¹,

Jeung²,

Warren³

et al. 2007

Addiction Biology

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show abstract

“…It should be noted that ondansetron does not affect amphetamine-induced stereotypies [13]. In contrast, ondansetron has recently been reported to oppose methamphetamine-induced hypophagia in mice that may therefore be mediated via 5-HT 3 receptors [121]. Peripherally located 5-HT 3 receptors are thought to mediate the anorectic response to amino acid deficiency generated experimentally in rats by amino acid imbalanced diets.…”

Section: -Ht 3 Receptors and Feedingmentioning

confidence: 99%

Monoamine Receptors in the Regulation of Feeding Behaviour and Energy Balance

Clifton

Kennett²

2006

CNSNDDT

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We evaluate the likely utility of drugs that interact, either directly or indirectly, with monoamine binding receptors for the treatment of obesity. We discuss ligands at dopaminergic, adrenergic, serotoninergic and histaminergic receptors and also drugs that either release or inhibit the reuptake of monoamine neurotransmitters. We review evidence from preclinical studies of receptor distribution and function, together with the consequences of gene deletion in transgenic mouse strains and the results from human studies where these are available. In addition we consider the side effect profiles that would be expected of these potential anti-obesity treatments. We conclude that compounds interacting with 5-HT(2C), 5-HT(6) and histamine H(3) receptors may be of particular interest as specific drug development targets for the treatment of appetite disturbance in obesity.

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“…The serotonin-2C receptor has been previously genetically associated with AIWG [8]; however the role of the serotonin-3 receptor (5-HT3) has not been explored. Ondansetron, a 5-HT3 antagonist that is used to treat chemotherapy-induced emesis [9], has been shown to block the suppression of food intake by serotonin [7] or methamphetamine administration [10]. Another 5-HT3 antagonist, tropisetron, blocks glucose-induced weight gain in mice [11].…”

Section: Introductionmentioning

confidence: 99%

Association Study of Serotonin 3 Receptor Subunit Gene Variants in Antipsychotic-Induced Weight Gain

et al. 2016

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Background: Schizophrenia (SCZ) is a chronic severe neuropsychiatric disorder, where pharmacological treatment has been hindered by adverse effects, including antipsychotic-induced weight gain (AIWG) and related complications. Genetic studies have been exploring the appetite regulation and energy homeostasis pathways in AIWG with some promising leads. The serotonin system has been shown to participate in these pathways. Methods: In the current study, we examined single nucleotide polymorphisms across the serotonin receptor genes HTR3A and HTR3B. Prospective weight change was assessed for a total of 149 SCZ patients of European ancestry. Results: We did not find the tested HTR3A or HTR3B gene markers to be associated with AIWG in our sample. Conclusion: Our preliminary findings suggest that these receptors may not play a major role in predicting AIWG.

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Ondansetron, a selective 5-HT3 antagonist, antagonizes methamphetamine-induced anorexia in mice

Cited by 13 publications

References 24 publications

PRECLINICAL STUDY: Changes in leptin, ghrelin, growth hormone and neuropeptide‐Y after an acute model of MDMA and methamphetamine exposure in rats

PRECLINICAL STUDY: Changes in leptin, ghrelin, growth hormone and neuropeptide‐Y after an acute model of MDMA and methamphetamine exposure in rats

Monoamine Receptors in the Regulation of Feeding Behaviour and Energy Balance

Association Study of Serotonin 3 Receptor Subunit Gene Variants in Antipsychotic-Induced Weight Gain

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