Oncothermia: Principles and Practices

Szász, András; Szász, Nóra; Szász, Olivér

doi:10.1007/978-90-481-9498-8

Cited by 76 publications

(80 citation statements)

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“…mEHT is based on the nano-thermal but not temperature-dependent effects of electromagnetic fields and special modulation (7), whose effect may exceed the effect of the overall heating (macroscopic temperature elevation) by 3-4-fold (8). mEHT does not require hyperthermia-range temperature and may be performed safely, without invasive thermal control.…”

Section: Introductionmentioning

confidence: 99%

“…mEHT does not require hyperthermia-range temperature and may be performed safely, without invasive thermal control. Unlike conventional hyperthermia, mEHT is also effective as monotherapy (7,9). Our previous phase II randomized trial on the combination of mEHT with traditional Chinese medicine (TCM) in colorectal cancer (9) suggested a synergetic effect of mEHT and TCM and was found to be sufficiently beneficial in PCMA patients for the present trial to be initiated.…”

Section: Introductionmentioning

confidence: 99%

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Local modulated electro-hyperthermia in combination with traditional Chinese medicine vs. intraperitoneal chemoinfusion for the treatment of peritoneal carcinomatosis with malignant ascites: A phase II randomized trial

Pang¹,

Zhang²,

Wang³

et al. 2017

Molecular and Clinical Oncology

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Abstract. The purpose of this study was to develop a safe and non-toxic alternative to the conventional conservative treatment of peritoneal carcinomatosis with malignant ascites (PCMA) by investigating the efficacy and safety of local modulated electro-hyperthermia (mEHT) combined with the traditional Chinese medicine (TCM) 'Shi Pi' herbal decoction, compared with standard intraperitoneal chemoinfusion (IPCI). A randomized, controlled, single-center, open-label clinical trial (phase II) with two parallel groups (allocation ratio, 1:1) was conducted to investigate the efficacy and safety of mEHT+TCM (study group, SG) vs. standard IPCI (control group, CG) in patients with PCMA by intention-to-treat analysis. A total of 260 patients with PCMA were randomly allocated into the two groups (130/130); mEHT was applied for 60 min per session every second day for 4 weeks, for a total of 14 sessions. The TCM decoction was administered orally, at 400 ml daily. In CG, occlusive IPCI with cisplatin (30-60 mg) and fluorouracil (500-600 mg/m 2 ) was applied twice, biweekly. The objective response rate (ORR), quality of life (QoL) and adverse event rate (AER) in the two groups were evaluated 1 month after treatment, analyzed and compared. The present study is registered on ClinicalTrials.gov (NCT02638051). No case was lost or excluded (0/260). The ORR in SG was 77.69% (101/130) vs. 63.85% (73/130) in CG (P<0.05). The QoL in SG was 49.23% vs. 32.3% in CG (P<0.05). The AER in SG was 2.3% (3/130) vs. 12.3% (16/130) in CG (P<0.05). All the adverse events were grade I. In conclusion, the combination of mEHT with TCM achieves better control of PCMA compared with standard IPCI, with less toxicity. Both components of the combination are non-toxic treatments easily tolerated by patients. Thus, this combined treatment may be preferred due to the better benefit-harm balance.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Local modulated electro-hyperthermia in combination with traditional Chinese medicine vs. intraperitoneal chemoinfusion for the treatment of peritoneal carcinomatosis with malignant ascites: A phase II randomized trial

Pang¹,

Zhang²,

Wang³

et al. 2017

Molecular and Clinical Oncology

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“…If we used the natural inhomogeneity of the tissues, we would be able to select the malignant cells, even their parts which we could excite by an external field. This is the nano-heating technology, which is realized by the mEHT applications [11] [13]. The naturally present membrane rafts of malignant cells are selectively heated up [82], producing at least 3˚C higher temperature on these nanoclusters of transmembrane proteins than their environment [83].…”

Section: Discussionmentioning

confidence: 99%

“…In this article we do not study the surgery-combined methods, only the non-invasive technics are considered. One special technique of oncologic hyperthermia is the modulated electro-hyperthermia (mEHT; trade name oncothermia) [11]. Its effects on effusions like malignant ascites are not cleared yet.…”

Section: Introductionmentioning

confidence: 99%

Electrokinetics of Temperature for Development and Treatment of Effusions

Szász¹,

Szigeti²,

Szász³

2017

ABB

Self Cite

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Introduction: Hyperthermia is a complementary therapy in oncology having various pros and contras for its application. Ascites, pleural effusion, edema and other electrolyte accumulations are frequently excluded from the treatability of the patients with heating locally or systemically. The special gathering of electrolytes is sometimes contraindicated, at times not mentioned in the clinical protocols. However, it is certainly challenging in the oncology where micro and macro edemas, as well as larger electrolyte accumulations (e.g. ascites, pleural effusion), are very frequent. Methods: Excluding patients with accumulation of free electrolytes limits the applications of hyperthermia. To find a solution we are studying the microvasculature and fluid dynamism together with the electric field effects, including the injury currents. The hyperthermia method which we investigate is the modulated electro-hyperthermia (mEHT). We use the Starling's equation and the injury current in the frame of non-equilibrium thermodynamics and in connection with the biologically closed electric circuits. Results: It is shown that mEHT, unlike the conventional hyperthermia, is applicable for patients who have edema and other free-electrolytes in the volume which is targeted. The heterogeneous heating (unlike the homogeneous, isothermal conventional hyperthermia) promotes the development of tumor-specific immune actions, and so has less adverse-effects, and longer survival time for patients in advanced, metastatic cancers too. Conclusion: mEHT is well applicable in cases of ascites, pleural effusion, edema and other electrolyte accumulations when a patient is treated in complex (complementary) oncological therapy.

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“…Oncothermia (OTM) is a kind of hyperthermia method intended to use of malignant diseases, [1]. OTM is based on electromagnetic interactions with the living matter, selecting the malignant cells as targets, [2].…”

Section: Introductionmentioning

confidence: 99%

Newer application of Oncothermia to non-malignant diseases such as Dupuytren's contracture of the hand and chronic lower back pain lasting more than 4 weeks

Máté¹,

Molnár²,

Szőke³

et al. 2017

acupunct electrother res

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ABSTRACT:Oncothermia (OTM) is based on electromagnetic interactions with the living matter. Its nano-targeting approach establishes a new paradigm. OTM could be applied not only to treat malignancies but it is feasible to apply for other diseases too. OTH is well proven method from the laboratory level to the clinical applications, promoting the natural processes, re-establishing of the synchronization between the cells. This approach allows therapy of some nonmalignant diseases too. Our objective is to use OTM for the irregularities of tissue-growth and for pain syndromes as well. OTM uses precisely tuned radiofrequency (RF) current flowing through the treated part of the body. We made extensive study, proving in details the applicability of the OTM for Dupuytren's contracture and chronic low back pain, in conjunction with permanent acupuncture method, a modified process of traditional Chinese Medicine (TCM). The synergy of the ancient and the state-of-art medical knowledges is the basic method of the present research. Our results with application of OTM for chronic low back pain and Dupuytren's contracture shows definite improvements of the patients involved in the study. We measured the success with the Visual Analog Scale (VAS), with anecdotic quality of life (QoL), and the shortening of the of-work period due to the disease. We measured that VAS decreased significantly, the hand contracture became less rigid and less contracted. The QoL of patients improved and their complaints which blocked their regular activity has significantly reduced. OTM method was safe & no adverse effects were observed. Recognition of the distortions in the healthy tissue have some common principles and possibilities in TCM and OTM: both the methods recognize the loss of complexity of the living organization. Data of our 122 HEgYI, g., MATE, A., MOLNAR, I., SzOkE, H.` 2 recent study verified the relevant end-points of our present study: the safety, the quality of life (QoL), the prolonged painless status of the patient.

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Oncothermia: Principles and Practices

Cited by 76 publications

References 0 publications

Local modulated electro-hyperthermia in combination with traditional Chinese medicine vs. intraperitoneal chemoinfusion for the treatment of peritoneal carcinomatosis with malignant ascites: A phase II randomized trial

Local modulated electro-hyperthermia in combination with traditional Chinese medicine vs. intraperitoneal chemoinfusion for the treatment of peritoneal carcinomatosis with malignant ascites: A phase II randomized trial

Electrokinetics of Temperature for Development and Treatment of Effusions

Newer application of Oncothermia to non-malignant diseases such as Dupuytren's contracture of the hand and chronic lower back pain lasting more than 4 weeks

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