Oncostatin M is expressed in atherosclerotic lesions: A role for Oncostatin M in the pathogenesis of atherosclerosis

Oncostatin M was associated with thrombosis in patients with atrial fibrillation

“…[24] Several reports demonstrated that OSM was involved in thrombogenesis in situ atherosclerotic lesions via TF-dependent pathway. [25] Mirshahi et al [13] further reported that OSM could adjust the balance between TF and TFPI, which is critical in blood clotting.…”

Oncostatin M binds to extracellular matrix in a bioactive conformation: Implications for inflammation and metastasis

“…Several studies have indicated a role for OSM in regulating pathological processes associated with chronic inflammation including cancer (11), arthritis (16, 17, 19, 20), Alzheimer’s disease (21–23), and atherosclerosis (24). Inflammation contributes to almost all aspects of tumor progression and is also a consequence of tumor development (62).…”

“…Furthermore, sustained STAT3 signaling in tumor cells has been shown to enhance proliferation, survival, angiogenesis, invasion, and tumor-promoting inflammation (32, 61). OSM contributes to the chronic inflammation associated with the progression of atherosclerosis via STAT1 and STAT3 signaling (24), and OSM-expressing macrophages are observed in lesions from all the patients examined (24). Unphosphorylated STAT3 has also been reported to mediate cell signaling (38, 86, 87) and to regulate and activate cellular programs associated with inflammation (37, 38).…”

“…OSM regulates proteolysis and extracellular matrix (ECM) turnover via the induction of cysteine and aspartic proteases, as well as metalloproteinases (3, 14, 15). In addition to its role in the inflammatory process associated with tumor progression, OSM drives other pathological conditions involving chronic inflammation including arthritis (16–20), Alzheimer’s disease (21–23) and atherosclerosis (24). The importance of inflammation in cancer is well established, since patients suffering from chronic inflammatory conditions such as pancreatitis, inflammatory bowel disease, prostatitis, and chronic obstructive pulmonary disease are more prone to develop cancer in affected tissues (25–28).…”

Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo

“…Although originally identified for its ability to inhibit tumorigenesis (9), OSM modulates a host of other biological processes that are cell type-dependent (10). Elevated OSM levels have been observed in a variety of inflammatory diseases in humans, including rheumatoid arthritis and atherosclerosis (11,12). OSM also has important roles in hepatic insulin resistance and steatosis (13), inflammation (14), and cardiomyocyte remodeling (15) and has several well characterized actions in the liver (16 -18).…”