Oncosis

Weerasinghe, Priya; Hallock, Sarathi; Brown, Robert E.; Buja, L. Maximilian

doi:10.1002/9781119432463.ch27

Cited by 1 publication

(1 citation statement)

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“…Oncosis is a form of programmed cell death characterized by organelle swelling and membrane disruption [ 177 ]. It is a type of cell injury that involves energy depletion, impairment of ionic pumps, swelling, dilation of the Golgi apparatus and endoplasmic reticulum, chromatin clumping, and the formation of cytoplasmic blebs [ 178 ].…”

Section: Depsipeptides With a Recognized Mechanism Of Targeting Cance...mentioning

confidence: 99%

Depsipeptides Targeting Tumor Cells: Milestones from In Vitro to Clinical Trials

2023

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Cancer is currently considered one of the most threatening diseases worldwide. Diet could be one of the factors that can be enhanced to comprehensively address a cancer patient’s condition. Unfortunately, most molecules capable of targeting cancer cells are found in uncommon food sources. Among them, depsipeptides have emerged as one of the most reliable choices for cancer treatment. These cyclic amino acid oligomers, with one or more subunits replaced by a hydroxylated carboxylic acid resulting in one lactone bond in a core ring, have broadly proven their cancer-targeting efficacy, some even reaching clinical trials and being commercialized as “anticancer” drugs. This review aimed to describe these depsipeptides, their reported amino acid sequences, determined structure, and the specific mechanism by which they target tumor cells including apoptosis, oncosis, and elastase inhibition, among others. Furthermore, we have delved into state-of-the-art in vivo and clinical trials, current methods for purification and synthesis, and the recognized disadvantages of these molecules. The information collated in this review can help researchers decide whether these molecules should be incorporated into functional foods in the near future.

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Section: Depsipeptides With a Recognized Mechanism Of Targeting Cance...mentioning

confidence: 99%