Oncoplastic Surgery in the Management of Breast Cancer

Shaitelman, Simona F.; Jeruss, Jacqueline S.; Pusic, Andrea L.

doi:10.1200/jco.19.02795

Cited by 22 publications

(23 citation statements)

References 51 publications

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“…The use of OBC has increased over time. 27 In 2014, 33% of all breast-conserving surgeries were performed using any type of oncoplastic surgery. 28 appointed consultant breast surgeons have to be familiar with mammaplasty techniques.…”

Section: Discussionmentioning

confidence: 99%

“…The use of OBC has increased over time. 27 In 2014, 33% of all breast-conserving surgeries were performed using any type of oncoplastic surgery. 28 Therefore, breast surgeons in training are increasingly exposed to these techniques, e.g., in the United Kingdom all newly appointed consultant breast surgeons have to be familiar with mammaplasty techniques.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective, Multicenter Analysis Comparing Conventional with Oncoplastic Breast Conserving Surgery: Oncological and Surgical Outcomes in Women with High-Risk Breast Cancer from the OPBC-01/iTOP2 Study

Fitzal¹,

Bolliger²,

Dunkler

et al. 2021

Ann Surg Oncol

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Introduction Recent data suggest that margins ≥2 mm after breast-conserving surgery may improve local control in invasive breast cancer (BC). By allowing large resection volumes, oncoplastic breast-conserving surgery (OBCII; Clough level II/Tübingen 5-6) may achieve better local control than conventional breast conserving surgery (BCS; Tübingen 1-2) or oncoplastic breast conservation with low resection volumes (OBCI; Clough level I/Tübingen 3-4). Methods Data from consecutive high-risk BC patients treated in 15 centers from the Oncoplastic Breast Consortium (OPBC) network, between January 2010 and December 2013, were retrospectively reviewed. Results A total of 3,177 women were included, 30% of whom were treated with OBC (OBCI n = 663; OBCII n = 297). The BCS/OBCI group had significantly smaller tumors and smaller resection margins compared with OBCII (pT1: 50% vs. 37%, p = 0.002; proportion with margin <1 mm: 17% vs. 6%, p < 0.001). There were significantly more re-excisions due to R1 (“ink on tumor”) in the BCS/OBCI compared with the OBCII group (11% vs. 7%, p = 0.049). Univariate and multivariable regression analysis adjusted for tumor biology, tumor size, radiotherapy, and systemic treatment demonstrated no differences in local, regional, or distant recurrence-free or overall survival between the two groups. Conclusions Large resection volumes in oncoplastic surgery increases the distance from cancer cells to the margin of the specimen and reduces reexcision rates significantly. With OBCII larger tumors are resected with similar local, regional and distant recurrence-free as well as overall survival rates as BCS/OBCI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Retrospective, Multicenter Analysis Comparing Conventional with Oncoplastic Breast Conserving Surgery: Oncological and Surgical Outcomes in Women with High-Risk Breast Cancer from the OPBC-01/iTOP2 Study

Fitzal¹,

Bolliger²,

Dunkler

et al. 2021

Ann Surg Oncol

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“… 1 , 2 The use of these techniques has become increasingly popular over the past 2 decades as they merge the curative intent of oncological surgery with plastic surgery techniques in an attempt to resect larger and/or multicentric tumors, reducing the necessity to perform mastectomies. 3 However, most of the evidence evaluating the benefit of OBC is based on small single-center studies, limiting its applicability and generalizability. 4 In this global retrospective study, we sought to determine whether OBC with large resection volumes improves local recurrence rates compared with conventional breast conservation or low-volume oncoplastic procedures in women with high-risk breast cancer.…”

Section: Pastmentioning

confidence: 99%

ASO Author Reflections: Impact of Resection Volume on Risk of Local Recurrence—The OPBC-01/iTOP2 Study

et al. 2021

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“…Die OBC könnte möglicherweise die Anzahl notwendiger Mastektomien reduzieren (▶ Abb. 1) [3,4]. Eine Reduktion nochmaliger Re-Operationen wegen geringeren R1-Resektionen wird der OBC eindeutig sicher zugeschrieben [5,6].…”

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Die onkoplastische Chirurgie und ihr Stellenwert

2022

Senologie - Zeitschrift für Mammadiagnostik und -therapie

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Oncoplastic Surgery in the Management of Breast Cancer

Abstract: Author affiliations and support information (if applicable) appear at the end of this article.

Cited by 22 publications

References 51 publications

Retrospective, Multicenter Analysis Comparing Conventional with Oncoplastic Breast Conserving Surgery: Oncological and Surgical Outcomes in Women with High-Risk Breast Cancer from the OPBC-01/iTOP2 Study

Retrospective, Multicenter Analysis Comparing Conventional with Oncoplastic Breast Conserving Surgery: Oncological and Surgical Outcomes in Women with High-Risk Breast Cancer from the OPBC-01/iTOP2 Study

ASO Author Reflections: Impact of Resection Volume on Risk of Local Recurrence—The OPBC-01/iTOP2 Study

Die onkoplastische Chirurgie und ihr Stellenwert

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