Oncolytic viruses as a promising therapeutic strategy for hematological malignancies

Yang, Chen; Hua, Nanni; Xie, Shufang; Wu, Yi; Zhu, Lifeng; Wang, Shibing; Tong, Xiangmin

doi:10.1016/j.biopha.2021.111573

Cited by 14 publications

(17 citation statements)

References 171 publications

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“…The inclusion criteria were as follows: (1) patients diagnosed as HMs by clinical examination; (2) first chemotherapy and placement of PICC catheter; (3) patients aged more than 18 years old, primary school education and above, with certain reading comprehension ability; and (4) conscious, informed consent, and voluntary participation in this study. Exclusion criteria were as follows: (1) patients who did not support or cooperate with tumor chemotherapy in this study, (2) patients with superior vena cava syndrome and severe hemorrhagic diseases that were not suitable for catheterization, and (3) severe hearing and visual impairment.…”

Section: General Informationmentioning

confidence: 99%

“…(1) In the form of face-to-face interviews, patients and their families are asked to recall the practice of PICC self-management process during this period, and patients are encouraged to talk about the problems or worries that may exist in the current PICC self-management behavior (such as being afraid to move or excessive activity). Analyze the internal and external causes of this unhealthy behavior, such as asking the patient "what benefits do you think this will bring to you?," help patients find alternative solutions, and correct the subjective benefit of patients' bad behavior (2) In the process of intervention, we should pay attention to the important value of family members in the self-management of patients' PICC, strengthen the health education to patients' families, and weaken the formation of patients' bad health behavior caused by external factors. The intervention time was 10~15 mins…”

Section: Identify the Vein And Insertion Site (A)mentioning

confidence: 99%

“…Hematological malignancies (HM), defined as a hematological malignant tumor, refers to a malignant clonal disease originating from the hematopoietic system, which occupies the sixth place in the incidence of all tumors [1]. The incidence rate in China is 2.76/100000 [2]. As we all know, intravenous chemotherapy is an indispensable part of com-prehensive treatment of HMs.…”

Section: Introductionmentioning

confidence: 99%

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Nursing Effect and Prognosis Analysis of Self-Management Education Model Based on Protective Motivation Theory on Patients with Hematological Tumor after PICC Catheterization

Jiang

Yang

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To analyze the nursing effect and prognostic value of self-management education model based on protective motivation theory on patients with hematological malignancies (HM) after peripheral venous catheterization (PICC). Methods. A total of 90 patients with HMs treated with PICC catheterization in our hospital from October 2019 to October 2021 were included in the study. The patients were randomly assigned into experimental group ( n = 45 ) and control group ( n = 45 ). On the basis of the control group, the experimental group implemented the self-management education model based on the theory of protective motivation, and the control group implemented routine nursing health education measures. The self-nursing ability scale (ESCA), Hamilton anxiety scale (HAMA), the average cost of PICC catheter maintenance, the incidence of PICC-related complications, and the score of Newcastle nursing satisfaction scale (NSNS) were observed 1 month before and after nursing. Results. After one month of nursing, there was no significant difference in ESCA self-concept ( p > 0.05 ). After one month of nursing, the scores of self-care responsibility, self-nursing skills, and health knowledge in the experimental group were significantly higher compared to those before nursing ( p < 0.05 ) and higher compared to those in the control group ( p < 0.05 ). After one month of nursing, the score of HAMA scale was significantly lower compared to that before nursing ( p < 0.05 ), and the score of HAMA scale in the experimental group was lower compared to the control group ( p < 0.05 ). After one month of nursing, the average cost of PICC pipeline maintenance in the test group was lower than that in the control group ( p < 0.05 ). One month after nursing, the incidence of PICC-related complications in the experimental group was lower than that in the control group ( p < 0.05 ). One month after nursing, the score of NSNS scale was significantly higher than that before nursing ( p < 0.05 ). After one month of nursing, the score of NSNS scale in the experimental group was higher than that in the control group. Conclusion. The self-management education model based on protective motivation theory is effective in nursing patients with peripheral venous catheterization and PICC catheterization of HMs. It is more beneficial to promote patients’ self-nursing management ability, reduce anxiety, reduce the average cost of PICC pipeline maintenance, reduce the incidence of PICC-related complications, and enhance nursing satisfaction.

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Section: General Informationmentioning

confidence: 99%

Section: Identify the Vein And Insertion Site (A)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nursing Effect and Prognosis Analysis of Self-Management Education Model Based on Protective Motivation Theory on Patients with Hematological Tumor after PICC Catheterization

Jiang

Yang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Immunotherapies are currently used in a wide spectrum of cancers, including carcinomas ( 1 ), sarcomas ( 2 ), and hematologic malignancies ( 3 ). Viral immunotherapies are based on oncolytic viruses, which are natural or engineered viruses that selectively replicate in and kill cancer cells without harming the normal tissues.…”

Section: Introductionmentioning

confidence: 99%

Toll-like Receptor Signaling–deficient Cells Enhance Antitumor Activity of Cell-based Immunotherapy by Increasing Tumor Homing

Morales-Molina

Rodríguez-Milla

Gambera

et al. 2023

Cancer Research Communications

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Cancer immunotherapy aims to activate the immune system. Some immunotherapeutic agents can be loaded in carrier cells for delivering to the tumors. However, a challenge with cell-based therapies is the selection of the appropriate cells to produce effective clinical outcomes. We hypothesize that therapies based on cells presenting a natural low pro-inflammatory profile (‘silent cells’) in the peripheral blood would result in better antitumor responses by increasing their homing to the tumor site. We studied our hypothesis in an immunotherapy model consisting of mesenchymal stromal cells (MSCs) carrying oncolytic adenoviruses for the treatment of immunocompetent mice. Toll-like receptor signaling-deficient cells (TLR4, TLR9 or MyD88 knockout) were used as ‘silent cells’, while regular MSCs were used as control. Although in vitro migration was similar in regular and knockout carrier cells, in vivo tumor homing of silent cells was significantly higher after systemic administration. This better homing to the tumor site was highly related to the mild immune response triggered by these silent cells in peripheral blood. As a result, the use of silent cells significantly improved the antitumor efficacy of the treatment in comparison to the use of regular MSCs. While cancer immunotherapies generally aim to boost local immune responses in the tumor microenvironment, low systemic inflammation after systemic administration of the treatment may indeed enhance their tumor-homing and improve the overall antitumor effect. These findings highlight the importance of selecting appropriate donor cells as therapeutic carriers in cell-based therapies for cancer treatment.

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“…Oncolytic virus (OV) therapy has recently been recognized as a promising therapeutic approach for cancer treatment. 4 , 5 Viruses preferentially infect, propagate, and kill tumor cells without causing damage to normal cells. 6 Over the past decade, enormous research has been reported on potential OVs and significant preclinical success.…”

Section: Introductionmentioning

confidence: 99%

NEBL and AKT1 maybe new targets to eliminate the colorectal cancer cells resistance to oncolytic effect of vesicular stomatitis virus M-protein

Mamizadeh

Kalani

Parsania

et al. 2021

Molecular Therapy - Oncolytics

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This study compares the oncolytic effect of vesicular stomatitis virus (VSV) wild type and M51R M-protein on the colorectal tumors of different invasive intensity on SW480 and HCT116 cell lines and 114 fresh colorectal cancer primary cell cultures. Fresh tumor samples were divided into two groups of lower stages (I/II) and higher stages (III/IV) regarding the medical records. The presence of two mutations in the PIK3CA gene and the expression of NEBL and AKT1 genes were evaluated. The cells were transfected with a plasmid encoding VSV wild-type and M51R mutant M-protein. Results showed either wild type or M51R mutant can kill SW480 and stage I/II primary cultures while mutant M-protein had no apoptotic effects on HCT116 cells and stage III/IV primary cultures. NEBL and AKT1 expression were significantly higher in resistant cells. Elevated caspase-9 activity confirmed that the intrinsic apoptosis pathway is the reason for cell death in lower-stage cells. Different tumors from the same cancer exhibit different treatment sensitivity due to genetic difference. NEBL and AKT1 gene expression may be responsible for this difference, which may be the target of future investigations. Therefore, tumor staging should be considered in oncolytic viral treatment as an interfering factor.

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Oncolytic viruses as a promising therapeutic strategy for hematological malignancies

Cited by 14 publications

References 171 publications

Nursing Effect and Prognosis Analysis of Self-Management Education Model Based on Protective Motivation Theory on Patients with Hematological Tumor after PICC Catheterization

Nursing Effect and Prognosis Analysis of Self-Management Education Model Based on Protective Motivation Theory on Patients with Hematological Tumor after PICC Catheterization

Toll-like Receptor Signaling–deficient Cells Enhance Antitumor Activity of Cell-based Immunotherapy by Increasing Tumor Homing

NEBL and AKT1 maybe new targets to eliminate the colorectal cancer cells resistance to oncolytic effect of vesicular stomatitis virus M-protein

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