Oncolytic virus-mediated p53 overexpression promotes immunogenic cell death and efficacy of PD-1 blockade in pancreatic cancer

Araki, Hiroyuki; Tazawa, Hiroshi; Kanaya, Nobuhiko; Kajiwara, Yoshinori; Yamada, Motohiko; Hashimoto, Masashi; Kikuchi, Shinichi; Kuroda, Shigetoshi; Yoshida, Ryuichi; Umeda, Yuzo; Urata, Yasuo; Kagawa, Shunsuke; Fujiwara, Toshiyoshi

doi:10.1016/j.omto.2022.09.003

Cited by 24 publications

(21 citation statements)

References 44 publications

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“…Due to poor immune responses, PDAC is refractory to PD-1 blockade therapy. More recently, it has been demonstrated the p53-expressing telomerase-specific oncolytic adenovirus OBP-702 induces ICD and anti-tumor immune responses in human PDAC cells with different p53 expression statuses ( Araki et al., 2022 ). Oncolytic OBP-702 adenovirus promotes ICD with secretion of extracellular adenosine triphosphate and HMGB1 by regulating p53-induced apoptosis and autophagy.…”

Section: Oncolytic Viruses-induced Immunogenic Cell Deathmentioning

confidence: 99%

“…Oncolytic OBP-702 adenovirus promotes ICD with secretion of extracellular adenosine triphosphate and HMGB1 by regulating p53-induced apoptosis and autophagy. Additionally, the OBP-702 significantly elevates the tumor infiltration of cytotoxic T cells and the anti-tumor efficacy of PD-1 blockade in a subcutaneous murine PDAC cells (PAN02) syngeneic tumor model ( Araki et al., 2022 ).…”

Section: Oncolytic Viruses-induced Immunogenic Cell Deathmentioning

confidence: 99%

“…Furthermore, Araki et al have demonstrated that oncolytic adenovirus OBP-702 promotes ICD with secretion of extracellular adenosine triphosphate and high-mobility group box protein B1 by regulating p53-induced apoptosis and autophagy. The OBP-702 significantly elevates the tumor infiltration of CD8 + T cells and the anti-tumor efficacy of PD-1 blockade in a subcutaneous PAN02 syngeneic tumor model (Araki et al, 2022). Japanese enveloped hemagglutination virus induces apoptosis and autophagy in human prostate cancer PC3 cells (Qian et al, 2018).…”

Section: Oncolytic Viruses-modulated Apoptosis Autophagy Syncytium Fo...mentioning

confidence: 99%

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Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response

Sun²,

Chen

et al. 2023

Front. Cell. Infect. Microbiol.

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Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis virus (VSV), parvovirus, mammalian reovirus (MRV), human adenovirus, Newcastle disease virus (NDV), herpes simplex virus (HSV), avian reovirus (ARV), Orf virus (ORFV), inactivated Sendai virus (ISV), enterovirus, and coxsackievirus offer unique opportunities in immunotherapy through diverse and dynamic pathways. This mini-review focuses on the mechanisms of OVs-mediated virotherapy and their effects on immunogenic cell death (ICD), apoptosis, autophagy and regulation of the immune system.

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Section: Oncolytic Viruses-induced Immunogenic Cell Deathmentioning

confidence: 99%

Section: Oncolytic Viruses-induced Immunogenic Cell Deathmentioning

confidence: 99%

Section: Oncolytic Viruses-modulated Apoptosis Autophagy Syncytium Fo...mentioning

confidence: 99%

See 1 more Smart Citation

Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response

Sun²,

Chen

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Furthermore, MLKL expressing VACV vectors induced a noticeable antitumor activity coupled with potent intrinsic antitumor immunity against neo-epitopes ( 82 ). On the other hand, Ad OBP-702 expressing p53, a tumor suppressor protein, substantially enhanced ICD via HMGB1 and ATP release by favoring apoptotic and autophagic cancer cell death ( 68 ). Ad/OBP-702-p53 thus promoted significant CD8 + T cell infiltration in pancreatic ductal adenocarcinoma (PDAC) tumors to achieve efficient antitumor response ( 68 ).…”

Section: Strategies To Modulate the Immunogenic Efficacy Of Ovsmentioning

confidence: 99%

Immunogenic cell death: The cornerstone of oncolytic viro-immunotherapy

Palanivelu

Lin

2023

Front. Immunol.

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According to the World Health Organization, cancer is one of the leading global health concerns, causing nearly 10 million deaths in 2020. While classical chemotherapeutics produce strong cytotoxicity on cancer cells, they carry limitations of drug resistance and off-target effects and sometimes fail to elicit adequate antitumor protection against tumor relapse. Additionally, most cancer cells have developed various ways to escape immune surveillance. Nevertheless, novel anticancer strategies such as oncolytic viro-immunotherapy can trigger immunogenic cell death (ICD), which can quickly grasp the attention of the host defense machinery, resulting in an ensuing antitumor immune response. Specifically, oncolytic viruses (OVs) can infect and destroy targeted cancer cells and stimulate the immune system by exposing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) to promote inflammatory reactions, and concomitantly prime and induce antitumor immunity by the release of neoantigens from the damaged cancer cells. Thus, OVs can serve as a novel system to sensitize tumor cells for promising immunotherapies. This review discusses the concept of ICD in cancer, centralizing ICD-associated danger signals and their consequence in antitumor responses and ICD induced by OVs. We also shed light on the potential strategies to enhance the immunogenicity of OVs, including the use of genetically modified OVs and their combination with ICD-enhancing agents, which are helpful as forthcoming anticancer regimens.

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“…This, in turn, elicits anti‐tumor CD4 + and CD8 + T‐cell responses 97 . Oncolytic adenovirus OBP‐702‐mediated p53 overexpression significantly enhanced ICD with secretion of extracellular ATP and HMGB1, contributing to augmenting the response to anti‐PD1 inhibitor in PAN02 syngeneic tumor model 98 . Oncolytic peptide LTX‐35 exhibited a strong anti‐tumor T‐cell immunity by inducing ICD via Bax/Bak‐mediated mitochondrial membrane permeabilization 99 .…”

Section: Crosstalk Between Microbes and Icd In Cancer Developmentmentioning

confidence: 99%

Microbes mediated immunogenic cell death in cancer immunotherapy

Huang

Duan

Xie

et al. 2023

Immunological Reviews

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SummaryImmunogenic cell death (ICD) is one of the 12 distinct cell death forms, which can trigger immune system to fight against cancer cells. During ICD, a number of cellular changes occur that can stimulate an immune response, including the release of molecules called damage‐associated molecular patterns (DAMPs), signaling to immune cells to recognize and attack cancer cells. By virtue of their pivotal role in immune surveillance, ICD‐based drug development has been a new approach to explore novel therapeutic combinations and personalized strategies in cancer therapy. Several small molecules and microbes can induce ICD‐relevant signals and cause cancer cell death. In this review, we highlighted the role of microbe‐mediate ICD in cancer immunotherapy and described the mechanisms through which microbes might serve as ICD inducers in cancer treatment. We also discussed current attempts to combine microbes with chemotherapy regimens or immune checkpoint inhibitors (ICIs) in the treatment of cancer patients. We surmise that manipulation of microbes may guide personalized therapeutic interventions to facilitate anticancer immune response.

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Oncolytic virus-mediated p53 overexpression promotes immunogenic cell death and efficacy of PD-1 blockade in pancreatic cancer

Cited by 24 publications

References 44 publications

Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response

Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response

Immunogenic cell death: The cornerstone of oncolytic viro-immunotherapy

Microbes mediated immunogenic cell death in cancer immunotherapy

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