Oncolytic Vaccinia Virus Expressing Aphrocallistes vastus Lectin as a Cancer Therapeutic Agent

Wu, Tao; Xiang, Yang; Liu, Tingting; Wang, Xue; Ren, Xiaoyuan; Ye, Ting; Li, Gongchu

doi:10.3390/md17060363

Cited by 19 publications

(24 citation statements)

References 49 publications

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“…A large number of studies have shown vaccinia virus to be well suited to biological cancer therapies. [29][30][31] It is worth noting that the combination of the oncolytic virus and Recent studies have shown MDA-7/IL-24 to control many mi-croRNAs, such as miR-221, which is upregulated in many types of cancer. 33 MDA-7/IL-24 downregulated miR-221, which in turn induces Beclin-1, leading to autophagy.…”

Section: Discussionmentioning

confidence: 99%

“…34,35 In our study, luteolin can increase VV-mediated IL-24 gene expression in liver cancer cells in vitro and in vivo. The ERK signaling pathway is necessary for the replication of vaccinia virus, 29 and whether luteolin promotes the expression of IL-24 through the ERK signaling pathway needs to be further explored. Furthermore, F I G U R E 4 VV-IL-24 and luteolin synergistically inhibit MHCC97-H cell growth in a mouse xenograft model.…”

Section: Discussionmentioning

confidence: 99%

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Luteolin enhances the antitumor efficacy of oncolytic vaccinia virus that harbors IL‐24 gene in liver cancer cells

Wang

Xiao

et al. 2020

Clinical Laboratory Analysis

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The pathogenesis of liver cancer involves genetic and epigenetic alterations. Usually, treatments such as surgical resection, local ablation and chemotherapy can only be effective in the early stage, but no therapies are available for advanced liver cancer. 1 Liver cancer is complex since it involves modifications and cross-talk among several signal pathways. 2 Therefore, the development of combination therapy could provide superior treatment for liver cancer in the future.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Luteolin enhances the antitumor efficacy of oncolytic vaccinia virus that harbors IL‐24 gene in liver cancer cells

Wang

Xiao

et al. 2020

Clinical Laboratory Analysis

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“…OncoVV-AVL was tested also on Balb/c nude mice bearing BEL-7404-or HCT116-derived tumors. In both cases, oncoVV-AVL efficiently inhibited tumor growth [63] (Table 2).…”

Section: Phylum Poriferamentioning

confidence: 91%

Antitumor Potential of Marine and Freshwater Lectins

et al. 2019

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Often, even the most effective antineoplastic drugs currently used in clinic do not efficiently allow complete healing due to the related toxicity. The reason for the toxicity lies in the lack of selectivity for cancer cells of the vast majority of anticancer agents. Thus, the need for new potent anticancer compounds characterized by a better toxicological profile is compelling. Lectins belong to a particular class of non-immunogenic glycoproteins and have the characteristics to selectively bind specific sugar sequences on the surface of cells. This property is exploited to exclusively bind cancer cells and exert antitumor activity through the induction of different forms of regulated cell death and the inhibition of cancer cell proliferation. Thanks to the extraordinary biodiversity, marine environments represent a unique source of active natural compounds with anticancer potential. Several marine and freshwater organisms, ranging from the simplest alga to the most complex vertebrate, are amazingly enriched in these proteins. Remarkably, all studies gathered in this review show the impressive anticancer effect of each studied marine lectin combined with irrelevant toxicity in vitro and in vivo and pave the way to design clinical trials to assess the real antineoplastic potential of these promising proteins. It provides a concise and precise description of the experimental results, their interpretation as well as the experimental conclusions that can be drawn.

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“…In vivo experiments showed that oncoVV-AVL induces a significant antitumor effect in colorectal cancer and liver cancer mouse models. These findings open the possibility of using the virus, containing marine lectin AVL, in oncolytic viral therapies [9].…”

mentioning

confidence: 87%

“…One article discusses the fatty acid composition and thermotropic behavior of glycolipids and other membrane lipids of green macrophyte Ulva lactuca [7]. Three articles cover lectin subjects [8][9][10]. One review article analyzes the results and perspectives of marine and freshwater lectins' application in experimental oncology and the therapy of oncological diseases; another article describes the use of a sponge lectin in the construction of a recombinant virus.…”

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confidence: 99%

Marine Glycoconjugates: Trends and Perspectives

2020

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Glycoconjugates play significant roles in biological systems and are used in medicine, for example as vaccines. Glycoproteins, peptidoglycans, lipopolysaccharides, and other biopolymer glycoconjugates are responsible for cellular interactions, including cell-cell recognition and the binding of cells to the intercellular matrix. These molecules perform signal, antigenic and transport functions, and participate in the formation of receptors and other important membrane and blood constituents. Due to the negative charges of some sulfated glycoconjugates and the binding of water, they are critical for maintaining the physical status of connective tissue [1]. Low molecular weight glycoconjugates, such as triterpene and steroidal glycosides [2][3][4], glycolipids, are also well known as molecules playing important internal and exterior roles. Diverse glycoconjugates show a very wide spectrum of biological activities, including defensive, cytotoxic, antitumor, immunomodulatory, and antioxidant properties. The water environment requires high solubility for signal or anti-predatory exometabolites of marine organisms, and carbohydrate moieties provide this property. All these peculiarities explain the very wide diversity of glycoconjugates of marine origin, including those presented in the current Special Issue.Sterol and sphingolipid glycoconjugates, which are widespread, but insufficiently studied metabolites of microalgae, were discussed by Stonik and Stonik in the review article. Glycosylated sterols play important biological roles in microalgae and show different beneficial properties useful for medicine and healthy food. Dietary sterols and their glycoconjugates of microalgae enter into marine invertebrates through food chains and may be converted into 7(8)-unsaturated sterols and their derivatives, such as polyhydroxylated sterols and, probably, glycosides of starfishes and sea cucumbers. The knowledge of microalgal glycosphingolipids still remains poor, despite intensive investigations. Some of them are important for their interactions with pathogens and may induce apoptosis in microalgae. They also participate in the termination of microalgal blooms [5].In their experimental article, Galasso et al. have discussed the obtaining and properties of a water-soluble bioactive fraction isolated from the toxic dinoflagellate Alexandrium minutem. This substance is a glycoprotein with a molecular weight above 20 kDa. It demonstrates specific antiproliferative activity (IC 50 = 0.4 µg/mL) against the A549 cell line (the human lung adenocarcinoma cells). Moreover, the glycoconjugate did not reveal a cytotoxicity against human normal lung fibroblasts (WI38), but induced cell death, triggered by mitochondrial autophagy (mitophagy) in tumor cells. No mitophagic events were activated by it in normal WI38 cells [6].Kostetsky et al. from the Far East Federal University (Vladivostok, Russia) have compared the fatty acid composition and thermal transitions of membrane lipids from green macroalgae Ulva lactuca, collected in the Sea of...

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Oncolytic Vaccinia Virus Expressing Aphrocallistes vastus Lectin as a Cancer Therapeutic Agent

Cited by 19 publications

References 49 publications

Luteolin enhances the antitumor efficacy of oncolytic vaccinia virus that harbors IL‐24 gene in liver cancer cells

Luteolin enhances the antitumor efficacy of oncolytic vaccinia virus that harbors IL‐24 gene in liver cancer cells

Antitumor Potential of Marine and Freshwater Lectins

Marine Glycoconjugates: Trends and Perspectives

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