Oncolytic vaccine virus harbouring the IL-24 gene suppresses the growth of lung cancer by inducing apoptosis

Lv, Chunwei; Su, Qunshu; Liang, Yupei; Hu, Jinqing; Yuan, Sujing

doi:10.1016/j.bbrc.2016.05.088

Cited by 27 publications

(22 citation statements)

References 25 publications

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“…In summary, although there have been investigations of Mda-7/IL-24 expression in a variety of tumours [21][22][23], this is the first study to analyse its association with C-myb in Burkitt patients to evaluate the prognostic significance. The present study revealed that low expression of Mda-7/IL-24 along with high expression of C-myb are associated with a worse clinical condition and outcomes in Burkitt lymphoma patients and further indicated the possible role of Cmyb in Mda-7/IL-24-induced terminal differentiation of Burkitt lymphoma cells; this outcome suggested they could be potent targets to establish new therapeutic strategies for improving the prognosis of patients with Burkitt lymphoma.…”

Section: Discussionmentioning

confidence: 98%

Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients

Zhao

Yang

et al. 2018

Hematology

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Section: Discussionmentioning

confidence: 98%

Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients

Zhao

Yang

et al. 2018

Hematology

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“…In addition, adenoviral vectors are widely used due to their large capacity with respect to exogenous genes and range of hosts. Ad-hIL-24 was constructed with a recombinant adenoviral vector, and has been shown to exert an inhibitory effect on various tumors ( 32 – 34 ). Recently, Ad-hIL-24 was demonstrated to be capable of reversing tumor drug resistance.…”

Section: Discussionmentioning

confidence: 99%

Reversal effect of adenovirus-mediated human interleukin 24 transfection on the cisplatin resistance of A549/DDP lung cancer cells

Tang

Sun

et al. 2017

Oncology Reports

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Interleukin-24 (IL-24) is a tumor-suppressor gene that has been documented in human melanoma cells. IL-24 has marked antitumor activities on various types of human cancer, but its underlying mechanism remains unclear. In the present, we investigated the effects of human IL-24 (hIL-24) on the chemotherapy resistance of lung cancer cells. The cisplatin (DDP)-resistant lung carcinoma cell line A549/DDP was subjected to adenovirus-mediated transfection with the human IL-24 gene (Ad-hIL-24). The growth-inhibitory and apoptotic effects of Ad-hIL-24 on A549/DDP cells were observed, and the expression levels of AKT, phosphorylated-AKT (p-AKT) and P-glycoprotein (P-gp) were detected. Ad-hIL-24 significantly decreased the levels of p-AKT and P-gp, and effectively inhibited A549/DDP cell growth. Furthermore, A549/DDP cells exhibited a significantly increased rate of apoptosis, as well as G2/M-phase arrest, following transfection with Ad-hIL-24, and these effects were increased in cells treated with Ad-IL-24 combined with DDP when compared with those treated with Ad-hIL-24 or DDP alone. These results suggest that hIL-24 can reverse the DDP resistance of lung cancer cells, and that the associated mechanism involves the induction of apoptosis and G2/M-phase arrest through the phosphoinositide3-kinase (PI3K)/AKT signaling pathway, as well as a decrease in drug resistance through P-gp expression.

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“…The production of these virus-encoded immune-regulatory factors by the virus-infected cells within the TME would have the ability to enhance the anti-tumor immune response potentially primed by viral lysis. Potential immune-enhancing molecules tested include chemokines [ 56 , 57 ], regulators of differentiation and maturation [ 58 , 59 ], and enhancers of antibody-based [ 60 ], as well as cell-mediated [ 61 ] immunity and molecules with direct cytopathic effects on cancer cells [ 62 ]. To date, the most extensively studied poxvirus cancer gene therapies have used vectors encoding the cell surface costimulatory molecules B7-1 (CD80), ICAM-1 (CD54), and LFA-3 (human CD58; murine CD48) termed collectively as TRICOM and the soluble enhancer of antigen-presenting dendritic cells/pathways GM-CSF.…”

Section: Recombinant Virusesmentioning

confidence: 99%

Recombinant Poxvirus and the Tumor Microenvironment: Oncolysis, Immune Regulation and Immunization

Sharp

Lattime

2016

Biomedicines

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Oncolytic viruses (OVs) are being extensively studied for their potential roles in the development of cancer therapy regimens. In addition to their direct lytic effects, OVs can initiate and drive systemic antitumor immunity indirectly via release of tumor antigen, as well as by encoding and delivering immunostimulatory molecules. This combination makes them an effective platform for the development of immunotherapeutic strategies beyond their primary lytic function. Engineering the viruses to also express tumor-associated antigens (TAAs) allows them to simultaneously serve as therapeutic vaccines, targeting and amplifying an immune response to TAAs. Our group and others have shown that vaccinating intratumorally with a poxvirus that encodes TAAs, in addition to immune stimulatory molecules, can modulate the tumor microenvironment, overcome immune inhibitory pathways, and drive both local and systemic tumor specific immune responses.

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Oncolytic vaccine virus harbouring the IL-24 gene suppresses the growth of lung cancer by inducing apoptosis

Cited by 27 publications

References 25 publications

Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients

Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients

Reversal effect of adenovirus-mediated human interleukin 24 transfection on the cisplatin resistance of A549/DDP lung cancer cells

Recombinant Poxvirus and the Tumor Microenvironment: Oncolysis, Immune Regulation and Immunization

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