Oncology nurse phone calls halve the risk of reduced dose intensity of immunochemotherapy: results of the randomized FORTIS study in chronic lymphocytic leukemia.

Ysebaert, Loïc; Larcher, Marie; Compaci, Gisèle; Obéric, Lucie; Sahnes, Laurence; Banos, Anne; Araujo, Carla; Sommet, Agnès; Laurent, Guy; Despas, Fabien

doi:10.1007/s00277-019-03631-z

Cited by 10 publications

(16 citation statements)

References 17 publications

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“…The Navigator procedure is a service offered to lymphoma patients treated as outpatients that involves the patient being contacted by a nurse via telephone twice a week. (19). The study included 4 (3.1%) patients with a prior medical history of depression, 6 (4,6%) with a current diagnosis of depression and 23 (17.8%) with a current diagnosis of generalized anxiety disorder.…”

Section: Resultsmentioning

confidence: 99%

Posttraumatic Stress Disorder Symptoms in Lymphoma Patients: A Prospective Study

et al. 2020

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The cancer experience may be marked by repeat stressors and/or traumas. The aim of our study was to assess traumatic events in a group of patients diagnosed with lymphoma and to determine which of these contribute to the development of Post-Traumatic Stress Disorder/PTSD. Two weeks after receiving a diagnosis of lymphoma, patients were referred for an assessment of peritraumatic distress (using the Peritraumatic Distress Inventory/PDI) and peritraumatic dissociation (using the Peritraumatic Dissociative Experiences Questionnaire/PDEQ). Three months after the diagnosis, we recorded the following parameters: the patients' worst experiences, the presence of PTSD symptoms, using the PTSD CheckList/PCL, as it related to the diagnosis, and symptoms of anxiety using the Hospital Anxiety and Depression/HAD scale and of depression using the Beck Depression Inventory/BDI-II. The study recruited 129 patients, with a mean age of 46 years (SD = 17.3); 70 (54%) men, 87 (67.5%) with Non-Hodgkin's lymphoma, and 42 with Hodgkin's lymphoma. Two weeks after the diagnosis, 49% of patients reported peritraumatic distress, and 20% peritraumatic dissociation, during or immediately after being informed of the lymphoma diagnosis. Three months after the diagnosis, the severity of PTSD symptoms was evaluated. At this stage none of the patients suffered PTSD, but 29 (23%) individuals exhibited partial PTSD: 13.4% correlated it to receiving the lymphoma diagnosis, 8% to telling family members, and 1.6% to adverse effects. Peritraumatic distress and dissociation as a result of receiving a lymphoma diagnosis, as well as anxiety and a mucositis within the first 3 months post-diagnosis, were factors that were significantly associated with PTSD symptoms, accounting for 35.8% in PTSD symptom load. Our study reveals that clinicians should assess the impact of a number of stressors, which are risk factors for PTSD symptoms, starting from the time point of the initial lymphoma diagnosis.

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Section: Resultsmentioning

confidence: 99%

Posttraumatic Stress Disorder Symptoms in Lymphoma Patients: A Prospective Study

et al. 2020

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“…More recently, AMA was used for monitoring lymphoma patient survivors [9]. Previous studies have suggested that the AMA procedure could improve the quality of clinical management, including observance, safety, comfort and reassurance [4,5]. We reasoned that such a procedure could be useful in LMIC to prevent refusal or abandonment of therapy, two major limitations of cancer care in underserved countries.…”

Section: Discussionmentioning

confidence: 99%

“…AMA also appeared to be efficient in its triage function, with considerable time saving for medical staff. More recently, a randomized study demonstrated that AMA could increase patient adherence in patients treated with chemotherapy for chronic lymphocytic leukemia [5].…”

Section: Introductionmentioning

confidence: 99%

AMAFRICA, a patient-navigator program for accompanying lymphoma patients during chemotherapy in Ivory Coast: a prospective randomized study

et al. 2019

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BackgroundPrevious studies have indicated that accompanying socially underserved cancer patients through Patient Navigator (PN) or PN-derived procedures improves therapy management and reassurance. At the Cancer Institute of Toulouse-Oncopole (France), we have implemented AMA (Ambulatory Medical Assistance), a PN-based procedure adapted for malignant lymphoma (ML) patients under therapy. We found that AMA improves adherence to chemotherapy and safety. In low-middle income countries (LMIC), refusal and abandonment were documented as major adverse factors for cancer therapy. We reasoned that AMA could improve clinical management of ML patients in LMIC.MethodsThis study was set up in the Abidjan University Medical Center (Ivory Coast) in collaboration with Toulouse. One hundred African patients were randomly assigned to either an AMA or control group. Main criteria of judgment were refusal and abandonment of CHOP or ABVD chemotherapy.ResultsWe found that AMA was feasible and had significant impact on refusal and abandonment. However, only one third of patients completed their therapy in both groups. No differences were noted in terms of complete response rate (CR) (16% based on intent-to-treat) and median overall survival (OS) (6 months). The main reason for refusal and abandonment was limitation of financial resources.ConclusionAltogether, this study showed that PN may reduce refusal and abandonment of treatment. However, due to insufficient health care coverage, its ultimate impact on OS remains limited.

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“…More recently, AMA was used for monitoring lymphoma patient survivors 9 . Previous studies have suggested that the AMA procedure could improve the quality of clinical management, including observance, safety, comfort and reassurance 4,5 . We reasoned that such a procedure could be useful The rate of treatment refusal and abandonment is very high (60%).…”

Section: Discussionmentioning

confidence: 99%

AMAFRICA, a patient-navigator program for accompanying lymphoma patients during chemotherapy in Ivory Coast: a prospective randomized study

Koffi

Silué

Laurent

et al. 2019

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Background Previous studies have indicated that accompanying socially undeserved cancer patients through Patient Navigator (PN) or PN-derived procedures improves therapy management and reassurance. At the Cancer Institute of Toulouse-Oncopole (France), we have implemented AMA (Ambulatory Medical Assistance), a PN-based procedure adapted for malignant lymphoma (ML) patients under therapy. We found that AMA improve adherence to chemotherapy and safety. In low-middle income countries (LMIC), refusal and abandonment were documented as major adverse factors for cancer therapy. We reasoned that AMA could improve clinical management of ML patients in LMIC. Methods This study was set up in the Abidjan University Medical Center (Ivory Coast) in collaboration with Toulouse. Hundred African patients were randomly assigned to either AMA or control group. Main criteria of judgment were refusal and abandonment of CHOP or ABVD chemotherapy. Results We found that AMA was feasible and has significant impact on refusal and abandonment. However, only one third of patients completed their therapy in both groups. No differences were noted in terms of complete response rate (CRR) (16% based on intent-to-treat) and median overall survival (OS) (6 months). The main reason for refusal and abandonment was limitation of financial resources. Conclusion Altogether, this study showed that PN may reduce refusal and abandonment of treatment. However, due to insufficient health care coverage, its ultimate impact on OS remains limited.

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Oncology nurse phone calls halve the risk of reduced dose intensity of immunochemotherapy: results of the randomized FORTIS study in chronic lymphocytic leukemia.

Cited by 10 publications

References 17 publications

Posttraumatic Stress Disorder Symptoms in Lymphoma Patients: A Prospective Study

Posttraumatic Stress Disorder Symptoms in Lymphoma Patients: A Prospective Study

AMAFRICA, a patient-navigator program for accompanying lymphoma patients during chemotherapy in Ivory Coast: a prospective randomized study

AMAFRICA, a patient-navigator program for accompanying lymphoma patients during chemotherapy in Ivory Coast: a prospective randomized study

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