This study aims to examine the specific health challenges experienced by cancer patients and survivors during the COVID-19 crisis. It's a descriptive mixed-methods study with 317 participants recruited from multiple sources. Participants were asked to complete an online anonymous 35-question semi-structured questionnaire. Data was analyzed both quantitatively and qualitatively. During the COVID-19 pandemic, 56% of the participants felt their medical care was disrupted or delayed. About 85% believed healthcare providers were taking the necessary measures to address COVID-19, yet, 50% of the participants felt they had received adequate information from healthcare providers. Participants had 49% satisfaction with general healthcare provided through telehealth, while only 33% were satisfied with telehealth cancer care. Common themes of challenges confronted by cancer patients during COVID-19 also include, delays in testing and treatment leading to cancer metastasis; lack of family and general support in hospitals/office visits, and feelings of isolation as a result of the quarantine; limited access to mental healthcare services; limited communication with medical personnel. There is an urgent need for medical and oncological institutions to create streamlined protocols for cancer treatment, appointments, and communication to minimize the number of challenges endured by cancer patients during a health pandemic.