Oncological progression of bone plasmacytoma to POEMS syndrome

Rathore, Narendra; Sharma, Ajay; Sathpathy, Shyama Prasanna; Walke, Rahul V.

doi:10.4103/0973-1482.87016

Cited by 4 publications

(3 citation statements)

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“…The average survival is around 13.7 years in large series analysis. Therapeutic options include: radiotherapy, indicated in cases of simple or multiple sclerotic lesions of limited location; chemotherapy (melphalan and prednisone, capable to produce an objective response in 90% of cases; cyclophosphamide or polychemotherapy); and autologous bone marrow transplantation, which can be used in young patients with disseminated osteosclerotic disease [ 5 , 20 , 21 ]. Monoclonal blocking antibodies for the VEGF receptor (bevacizumab) were employed successfully according to some reports [ 5 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Manifestations in POEMS Syndrome: Case Report and Review

Marinho¹,

Pirmez²,

Nogueira³

et al. 2015

Case Rep Dermatol

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The authors report a case of sensorimotor polyneuropathy, diffuse cutaneous hyperpigmentation, skin sclerodermiform thickening and papular lesions in the infraclavicular and abdominal region. Besides weight loss, there were diabetes mellitus and hypothyroidism. The alterations were consistent with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes) syndrome, which is a rare systemic disease with monoclonal proliferation of plasmacytes and slow progression. Cutaneous alterations are present in 68% of patients with diffuse cutaneous hyperpigmentation, plethora and acrocyanosis. Leukonychia, necrotizing vasculitis, hypertrichosis and cutaneous thickening of sclerodermiform type are also cited. The onset of multiple cutaneous angiomas in this syndrome has been observed in 24-44% of patients.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Manifestations in POEMS Syndrome: Case Report and Review

Marinho¹,

Pirmez²,

Nogueira³

et al. 2015

Case Rep Dermatol

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“…The majority of literature reported an improvement of polyneuropathy after management of plasmacytoma [5,[12][13][14], whereas some authors reported development of POEMS syndrome despite initial management of solitary plasmacytoma after several years [15,16]. Although our patient has been maintaining remission state during 1-year follow-up period, close observation may be needed, considering possibility of evolvement to POEMS or multiple myeloma.…”

Section: Discussionmentioning

confidence: 79%

Remission of Chronic Acquired Demyelinating Polyneuropathy Associated With Paraproteinemia After Removal of Skull Plasmacytoma

2017

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Chronic acquired demyelinating polyneuropathy can be caused by various etiologies. Although chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most common chronic acquired demyelinating polyneuropathy, currently there is no suitable biomarker to diagnose CIDP; hence misdiagnosis of CIDP has not been unusual. Herein, we present a patient with initially presumed CIDP, who maintains disease remission after early surgical removal of solitary plasmacytoma during 1-year follow-up. A 55-year-old woman was referred to our hospital due to progressive upper and lower extremity weakness from 6 months ago. Nerve conduction study findings were compatible with acquired demyelinating polyneuropathy, fulfilling electrodiagnostic criteria of CIDP. Serum electrophoresis suggested monoclonal gammopathy of lambda type, but the bone marrow biopsy showed no evidence of neoplastic plasma cell infiltration. Brain magnetic resonance imaging revealed an osteolytic mass involving the right parietal skull and adjacent dura mater. Total excision of the skull mass was performed. The biopsy result was compatible with plasmacytoma. Even without long term administration of high dose corticosteroid, the patient not only has continued to improve clinically, but also showed markedly improved electrophysiological findings during 1-year follow-up.

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“…In some cases, plasmacytoma precedes the development of POEMS syndrome but in this case it was the reverse. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

POEMS syndrome associated with plasmacytoma of the clivus

Thomas

Maramattom

Varghese

et al. 2016

Journal of Postgraduate Medicine

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Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) syndrome is characterized by the presence of a monoclonal plasma cell disorder, peripheral neuropathy, and one or more of the following features: Osteosclerotic myeloma, Castleman's disease (angiofollicular lymph node hyperplasia), increased levels of serum vascular endothelial growth factor (VEGF), organomegaly, endocrinopathy, edema, typical skin changes, and papilledema.[1] Solitary plasmacytomas most frequently occur in the bone but can also be found in soft tissues (extramedullary plasmacytoma).[2] We report a case that showed a rare association of POEMS syndrome with a plasmacytoma of the clivus.

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Oncological progression of bone plasmacytoma to POEMS syndrome

Cited by 4 publications

References 0 publications

Cutaneous Manifestations in POEMS Syndrome: Case Report and Review

Cutaneous Manifestations in POEMS Syndrome: Case Report and Review

Remission of Chronic Acquired Demyelinating Polyneuropathy Associated With Paraproteinemia After Removal of Skull Plasmacytoma

POEMS syndrome associated with plasmacytoma of the clivus

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