Oncological outcomes of minimally invasive partial versus minimally invasive radical nephrectomy for cT1-2/N0/M0 clear cell renal cell carcinoma: a propensity score-matched analysis

Simone, Giuseppe; Tuderti, Gabriele; Anceschi, Umberto; Papalia, Rocco; Ferriero, Mariaconsiglia; Misuraca, Leonardo; Minisola, Francesco; Mastroianni, Riccardo; Costantini, Manuela; Guaglianone, Salvatore; Sentinelli, Steno; Gallucci, Michele

doi:10.1007/s00345-016-1923-2

Cited by 33 publications

(32 citation statements)

References 22 publications

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“…T a g g e d E n d T a g g e d P Keywords: Robotic partial nephrectomy; Upstaging; Outcomes; PredictorsT a g g e d E n d T a g g e d H 1 1. IntroductionT a g g e d E n d T a g g e d P The exponential increase in early detection of kidney cancer has dramatically changed its management over the past 2 decades, and partial nephrectomy (PN) has replaced radical nephrectomy as standard surgical treatment for T1 disease [1,2]. A paradigm shift towards PN was also observed in the management of T1b and T2 renal masses [3−5].…”

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confidence: 99%

Upstaging to pT3a disease in patients undergoing robotic partial nephrectomy for cT1 kidney cancer: Outcomes and predictors from a multi-institutional dataset

Veccia

Antonelli

Minervini

et al. 2020

Urologic Oncology: Seminars and Original Investigations

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confidence: 99%

Upstaging to pT3a disease in patients undergoing robotic partial nephrectomy for cT1 kidney cancer: Outcomes and predictors from a multi-institutional dataset

Veccia

Antonelli

Minervini

et al. 2020

Urologic Oncology: Seminars and Original Investigations

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“…To date, partial nephrectomy is recommended as the preferred option for T1 tumours, if it is technically feasible 27–31 . There are no differences in terms of surgical radicality, cancer-specific survival and overall survival between open, laparoscopic or robot-assisted radical nephrectomy 32 .…”

Section: Management Of Localized Diseasementioning

confidence: 99%

Management of kidney cancer patients: 2018 guidelines of the Italian Medical Oncology Association (AIOM)

et al. 2019

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In the past two decades, the treatment landscape for patients with metastatic renal cell carcinoma has significantly changed thanks to the approval of several targeted molecular therapies (VEGF and mTOR inhibitors) and recently immune-checkpoint inhibitors. The Italian Association of Medical Oncology (AIOM) Renal Cell Cancer (RCC) Guidelines Panel has developed clinical guidelines to provide evidence-based information and recommendations to oncologists, urologists and all professionals involved in the management of patients with renal cell cancer.

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“…2 An analysis from Italy showed no significant difference in metastasis-free survival, local recurrence-free survival, CSS, and OS between PN and RN patients. 3 On the contrary, another report suggested that patients over 65 years who undergo PN have longer OS than those who undergo RN. 4 In terms of surgical complications, the European Organization for the Research and Treatment of Cancer (EORTC) showed that PN was associated with slightly higher complication rates compared to RN, while PN was found to be an acceptable treatment for patients with small RCC.…”

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confidence: 99%

Impact of Radical Nephrectomy and Partial Nephrectomy on Actual Estimated Overall Survival Compared to Life Expectancy in Patients with Renal Cell Carcinoma

Tanaka

Nakai

Miyake

et al. 2021

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Reports suggest that partial nephrectomy provides no significant benefit in terms of cancer-specific and overall survival (OS) compared to radical nephrectomy. Here, we focused on survival in terms of life expectancy and investigated the significance of partial nephrectomy for localized renal cell carcinoma (RCC) patients. Patients and Methods: Our retrospective study included 937 patients (median age 63 years) with localized RCC who underwent partial nephrectomy or radical nephrectomy. Various predictive factors were explored, and the association between actual OS and life expectancy was analyzed. Results: Performance status (PS) ≥1 and tumor size ≥40 mm were identified as independent poor prognostic factors for cancer-specific survival. Age ≥60, male sex, PS ≥1, C-reactive protein elevation, pT1b stage, and radical nephrectomy were identified as independent poor prognostic factors for OS. OS and life expectancy did not differ in the partial nephrectomy group (P=0.11). OS was significantly shorter than life expectancy in the radical nephrectomy group (P<0.0001). In PS0 or pT1a patients, there was a significant difference between actual OS and life expectancy in the radical nephrectomy group (P<0.0001), but not in the partial nephrectomy group (P=0.15). In patients with a life expectancy ≥10 years, PS0, and pTa, OS and life expectancy differed in the radical nephrectomy group, but not in the partial nephrectomy group. Conclusion: Partial nephrectomy can improve actual OS, and notably, PS and tumor size are crucial factors that determine the choice of surgical procedure. Further research is needed to establish appropriate treatment strategies and criteria for clinical practice.

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Oncological outcomes of minimally invasive partial versus minimally invasive radical nephrectomy for cT1-2/N0/M0 clear cell renal cell carcinoma: a propensity score-matched analysis

Abstract: PN and RN for patients with cc-RCC larger than 7 cm provided equivalent oncologic outcomes. Safety and reproducibility of our findings should be further investigated in larger multicentric cohorts.

Cited by 33 publications

References 22 publications

Upstaging to pT3a disease in patients undergoing robotic partial nephrectomy for cT1 kidney cancer: Outcomes and predictors from a multi-institutional dataset

Upstaging to pT3a disease in patients undergoing robotic partial nephrectomy for cT1 kidney cancer: Outcomes and predictors from a multi-institutional dataset

Management of kidney cancer patients: 2018 guidelines of the Italian Medical Oncology Association (AIOM)

Impact of Radical Nephrectomy and Partial Nephrectomy on Actual Estimated Overall Survival Compared to Life Expectancy in Patients with Renal Cell Carcinoma

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