Oncological and Renal Function Outcomes in Patients Who Underwent Simultaneous Radical Cystectomy and Nephroureterectomy for Synchronous or Metachronous Panurothelial Carcinoma

Subiela, José Daniel; González-Padilla, D.A.; Huguet, J.; Aumatell, Júlia; Rodríguez-Faba, Óscar; Krajewski, Wojciech; Feliu, Alejandro Hevia; Mínguez, Cesar; Plaza, J. L. de la; Medina, A. Artiles; Gajate, Pablo; Cidre, Miguel Ángel Jiménez; Revilla, Javier Burgos; Breda, Alberto; Palou, Joan

doi:10.1016/j.urology.2022.08.064

Cited by 1 publication

(2 citation statements)

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“…Three studies ( 11 , 12 , 21 ) reported two-year and five-year recurrence-free survival rates after RCUN. Meta-analysis showed that the recurrence-free survival rate was 91% (95% CI 86%, 95%, I 2 = 95%, P < 0.001) at 2 years ( Figure 6A ), and 65% (95% CI 58%, 73%, I 2 = 91.5%, P < 0.001) at 5 years ( Figure 6B ).…”

Section: Resultsmentioning

confidence: 99%

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Simultaneous radical cystectomy and nephroureterectomy in the treatment of panurothelial carcinoma: a systematic review and single-arm meta-analysis

Liu,

Zhang,

Wen

et al. 2023

Front. Oncol.

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BackgroundPanurothelial carcinoma is a rare and aggressive malignancy that requires effective treatment strategies to enhance patient outcomes.MethodsWe conducted a systematic search of English publications in databases including PubMed, Embase, Cochrane Library, and Web of Science up to May 2023. The quality of the literature was assessed using the Newcastle-Ottawa Scale (NOS) and the Methodological Quality and Synthesis of Case Series and Case Reports tool. Data statistics and analysis were performed using Stata 15.1 software (StataSE, USA).ResultsSix studies involving 339 patients were included in the analysis. Meta-analysis revealed that Simultaneous Radical Cystectomy and Nephroureterectomy had 2-year and 5-year overall survival rates of 68% (95% CI 60%-76%, I2 = 12.4%, P < 0.001) and 44% (95% CI 36%-53%, I2 = 0, P < 0.001), respectively. The 2-year and 5-year progression-free survival rates were 91% (95% CI 86%-95%, I2 = 95%, P < 0.001) and 65% (95% CI 58%-73%, I2 = 91.5%, P < 0.001), respectively. The 2-year and 5-year cancer-specific survival rates were 73% (95% CI 66%-81%, I2 = 16.7%, P < 0.001) and 57% (95% CI 49%-66%, I2 = 0, P < 0.001), respectively. Additionally, the incidence of minor complications was 19% (95% CI 15%-23%, P < 0.01), major complications was 49% (95% CI 34%-63%, P < 0.01), and the intraoperative blood transfusion rate was 53% (95% CI 44%-61%, P < 0.01).ConclusionsSimultaneous radical cystectomy and nephroureterectomy represent feasible approaches for the treatment of Panurothelial carcinoma. Nonetheless, a comprehensive assessment of the surgical risks and benefits is imperative, and larger-scale prospective cohort studies are required to validate therapeutic efficacy. Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023426401.

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Section: Resultsmentioning

confidence: 99%

“…However, the safety and efficacy of RCUN in the treatment of Panuc patients remain unclear due to the limited sample sizes of these studies ( 9 , 10 ), Recently, large-scale studies by Subiela et al. ( 11 ) and Britton et al. ( 12 ) have reported on the treatment of Panuc with RCUN.…”

Section: Introductionmentioning

confidence: 99%