Oncological and pregnancy outcomes after high-dose density neoadjuvant chemotherapy and fertility-sparing surgery in cervical cancer

Incidence, risk factors and treatment of cervical stenosis after radical trachelectomy: A systematic review

“…The impact of neoadjuvant chemotherapy on stenosis is unclear. Based on the limited articles published in the literature, the incidence of cervical stenosis after neoadjuvant chemotherapy and VRT, which varied from 16.7% to 25%, was higher than that without neoadjuvant chemotherapy [29][30][31]. Robova et al hold the opinion that this might due to change of the tissues after chemotherapy.…”

Neoadjuvant chemotherapy followed by large cone resection as fertility-sparing therapy in stage IB cervical cancer

“…ACCEPTED MANUSCRIPT 12 Six of our patients got pregnant with a total of 7 delivered babies. In our case we see a low chance of preterm delivery of 33% and no extreme preterm deliveries.…”

“…[11] The option of neoadjuvant chemotherapy (NACT) has been described for above performed surgery. [12,13] Another option is conization which can be performed in a selected group of patients in the low-risk group FIGO stage IA2 to IB1 disease. [10] Tumor size smaller than 2 cm, negative lymphovascular space invasion (LVSI), stromal invasion less than 10 mm and low risk histological types (squamous, adeno-and adenosquamous carcinoma) are prognostic factors that have been proposed as criteria to perform conservative surgery.…”

Fertility-sparing management of gynecological cancers

“…Several authors published small series of patients diagnosed with bulky tumors of the cervix (FIGO IB > 2 cm up to FIGO IIA1 disease) who underwent conservative surgery after neoadjuvant chemotherapy (NACT) [17][18][19][20]. See Table 1.…”