Oncologic outcomes after surgery for locally aggressive basal cell carcinoma of the head and neck

Gill, Amarbir S.; Nittur, Vinay; Moore, Michael G.; Farwell, D. Gregory; Bewley, Arnaud F.

doi:10.1002/lary.27882

Cited by 2 publications

(3 citation statements)

References 20 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of BCCs occur in the head and neck [3]. Carcinomas of the external auditory canal (EAC) are rare tumors.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Basal cell carcinoma of the external auditory canal: Case report and literature review

Soussy¹,

Lahmer²,

Hammas³

et al. 2023

Our Dermatol Online

View full text Add to dashboard Cite

Basal cell carcinoma is a common, slowly growing, locally aggressive, and rarely metastatic skin cancer. Primary BCCs of the external auditory canal are extremely rare. A 67-year-old patient presented chronic otitis media associated with a mass in the concha and the external auditory canal of the left ear. The patient was diagnosed with basal cell carcinoma of the EAC. Locoregional assessment on a CT scan revealed thickening of soft tissues in the external left auricle and external auditory canal. She underwent surgery. Given the insufficient margins, adjuvant radiotherapy was indicated. Radiotherapy was performed with the intensity-modulated radiation therapy technique in order to the overcome anatomical complexity of the region, cover the tumor bed, and preserve the organs at risk. BCC of the EAC is a rare and challenging entity, whose management is multidisciplinary. The main goal is to avoid local recurrence, as well as to improve the patient’s quality of life.

show abstract

“…The majority of BCCs occur in the head and neck [3]. Carcinomas of the external auditory canal (EAC) are rare tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Surgery on BCC of the EAC is quite challenging. Due to the particular location of these tumors, the ability to perform a wide excision remains difficult, in addition to the aggressiveness of certain histological subtypes [3].…”

Section: Discussionmentioning

confidence: 99%

Basal cell carcinoma of the external auditory canal: Case report and literature review

Soussy¹,

Lahmer²,

Hammas³

et al. 2023

Our Dermatol Online

View full text Add to dashboard Cite

show abstract

“…Radiotherapy can be considered when surgery is not feasible for locally advanced tumors. Targeted chemotherapy, such as Sonic Hedgehog pathway inhibitors, is used for metastatic or locally advanced basal cell carcinoma that cannot be treated with surgery or radiation [ 6 , 7 ]. Locally aggressive basal cell carcinoma of head and neck patients experience a high rate of local recurrence but low disease-specific mortality when treated with primary surgery and selected use of adjuvant treatment [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Association of the Depth of Invasion With Recurrence Rates of Basal Cell Carcinoma in a Tertiary Health Care Facility: A Retrospective Study Over a Period of Six Years

Unar¹,

Khan²,

Zahid³

et al. 2023

Cureus

View full text Add to dashboard Cite

BackgroundBasal cell carcinoma (BCC) is one of the most common types of cutaneous malignancies and the most frequently occurring form of cancer worldwide. The incidence of basal cell carcinoma is difficult to determine due to its wide geographic variations; however, it has been increasing worldwide with an annual increase of 7% in the number of reported cases. Although BCC is more prevalent in the aging population, diagnosis in younger individuals is steadily increasing. BCC has overall low mortality, however, it leads to significant economic and physical impact on patients and their families along with adding burden to the healthcare system. The primary risk factor for the development of BCC is increased cumulative sun exposure, particularly to UV radiation. The UV index of Karachi averages around 12 (extremely high) during summer months, putting the population at a significantly higher risk of developing BCC in the long term. ObjectivesThis audit was undertaken with the following primary objectives: to use the data collected to determine possible prognostic factors for BCC, to measure the rate of recurrence and the number of new primary tumors detected, to study the completeness of follow-up by patients, and to co-relate histopathological findings with the recurrence rate of basal cell carcinoma. MethodsA retrospective analysis was performed for all patients with BCC who had undergone surgical resection over a six-year time period. Patient charts were reviewed for demographic information, tumor size, onset-todiagnosis, anatomic location, clinical subtype, histologic differentiation, method of surgical treatment, and recurrence. Data were entered and analyzed in SPSS version 23 (IBM Corp., Armonk, NY). ResultsThe review identified cases of BCC in 99 patients. Of the 99 patients, 60.39% were men and 38.38% were women. The most frequent age group was 65-85-year-olds (42 patients, 42.85%) for BCC. Based on the aesthetic units of the face, the most common location was the nasal unit (30 cases, 30.30%) for BCC. Most of the lesions were closed primarily; however; local flaps were used in the case of surgical defects. The recurrence rate was 19.19% for BCC in this study. Our study included 1.0% of patients who were classified as Clark classification level 2 of BCC, 6.1% as Clark level 3, 23.4% as Clark level 4, and 0.16% as Clark level 5. Recurrence rates were seen to increase with increasing Clark classification level in this study.

show abstract

Oncologic outcomes after surgery for locally aggressive basal cell carcinoma of the head and neck

Cited by 2 publications

References 20 publications

Basal cell carcinoma of the external auditory canal: Case report and literature review

Basal cell carcinoma of the external auditory canal: Case report and literature review

Association of the Depth of Invasion With Recurrence Rates of Basal Cell Carcinoma in a Tertiary Health Care Facility: A Retrospective Study Over a Period of Six Years

Contact Info

Product

Resources

About