Oncologic outcomes after nipple‐sparing mastectomy: A single‐institution experience

Frey, Jordan D.; Alperovich, Michael; Kim, Jennifer Chun; Axelrod, Deborah; Shapiro, Richard L.; Choi, Mihye; Schnabel, Freya; Karp, Nolan S.; Guth, Amber

doi:10.1002/jso.24097

Cited by 32 publications

(19 citation statements)

References 18 publications

(45 reference statements)

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“…2 The use of NSM for patients receiving NCT is increasingly described in the literature. 5–7,15 A recent series reported an increase in the proportion of therapeutic NSM patients receiving NCT from 8 to 21% over a 5-year period. 16 In our study, 12.7% of NSM patients received NCT.…”

Section: Discussionmentioning

confidence: 99%

Nipple-Sparing Mastectomy is Not Associated with a Delay of Adjuvant Treatment

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Nipple-Sparing Mastectomy is Not Associated with a Delay of Adjuvant Treatment

et al. 2018

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“…Recent critical analyses have suggested that the only true independent preoperative predictors are clinical or radiographic evidence of involvement of the NAC . As such, several authors have proposed expanding the indications for NSM, such that these are the only absolute contraindications, provided that intraoperative pathologic evaluation is performed .…”

Section: Introductionmentioning

confidence: 99%

Nipple-sparing mastectomy: A contemporary perspective

Sisco

Yao

2016

J. Surg. Oncol.

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“…NSM is associated with excellent aesthetic results and oncologic outcomes that seem equivalent to traditional mastectomy techniques, such as total and skin-sparing mastectomy. 1 , 2 , 6 , 7 , 10 , 20 , 42 However, reconstructive outcomes and risk factors for reconstructive complications in NSM continue to be defined. 9 – 11 , 14 Smoking, obesity, periareolar mastectomy incisions, radiation, and chemotherapy, among other factors, have all been identified as risk factors for adverse outcomes, specifically ischemic complications, after NSM.…”

Section: Discussionmentioning

confidence: 99%

Mastectomy Flap Thickness and Complications in Nipple-Sparing Mastectomy: Objective Evaluation using Magnetic Resonance Imaging

Frey

Salibian

Choi

et al. 2017

Plastic and Reconstructive Surgery - Global Open

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Background:Ischemic complications after nipple-sparing mastectomy (NSM) have been associated with numerous variables. However, the impact of NSM flap thickness has been incompletely evaluated.Methods:NSM flap thickness was determined for all NSMs from 2006 to 2016 with available pre- or postoperative breast magnetic resonance imaging (MRIs). Demographics and outcomes were stratified by those with and without ischemic complications.Results:Of 1,037 NSM reconstructions, 420 NSMs had MRI data available, which included 379 preoperative MRIs and 60 postoperative MRIs. Average total preoperative skin/subcutaneous tissue NSM flap thickness was 11.4 mm. Average total postoperative NSM flap thickness was 8.7 mm. NSMs with ischemic complications were found to have significantly thinner overall postoperative NSM flap thickness compared with those without ischemic complications (P = 0.0280). Average overall postoperative NSM flap thickness less than 8.0 mm was found to be an independent predictor of ischemic complications (odds ratio, 6.5263; P = 0.026). In NSMs with both pre- and postoperative MRIs, the overall average postoperative NSM flap thickness was 68.2% of preoperative measurements. Average overall postoperative NSM flap thickness was significantly less than average overall preoperative NSM flap thickness (P < 0.0001). NSMs with ischemic complications were found to have a significantly lower ratio of overall postoperative to preoperative flap thickness (52.0% versus 74.0%; P < 0.0001).Conclusions:Ischemic complications after NSM are significantly associated with thinner postoperative NSM flap thickness. Particularly, NSM flap thickness less than 8.0 mm is a positive independent predictor of ischemic complications. The ratio of postoperative to preoperative NSM flap thickness was significantly lower in reconstructions with ischemic complications.

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Oncologic outcomes after nipple‐sparing mastectomy: A single‐institution experience

Abstract: We examined our institutional outcomes with NSM and found a locoregional recurrence rate of 0.8% with no nipple-areolar complex recurrence. This rate is lower than published rates for both NSM and SSM.

Cited by 32 publications

References 18 publications

Nipple-Sparing Mastectomy is Not Associated with a Delay of Adjuvant Treatment

Nipple-Sparing Mastectomy is Not Associated with a Delay of Adjuvant Treatment

Nipple-sparing mastectomy: A contemporary perspective

Mastectomy Flap Thickness and Complications in Nipple-Sparing Mastectomy: Objective Evaluation using Magnetic Resonance Imaging

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