Oncologic Outcome of ypT1-2N0 Rectal Cancer After Neoadjuvant Chemoradiotherapy Compared With pT1-2N0 Rectal Cancer

Oh, Seung Yeop; Kim, Young Bae; Suh, Kwang Wook

doi:10.1097/coc.0000000000000196

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…Li et al have used propensity score-matching to analyze 168 matched pairs of rectal cancer patients with ypStage I and pStage I, and demonstrated similar prognoses; however, 45.2% of ypStage I patients were treated using AC whereas no pStage I patients received AC, which may have influenced the survival outcomes (27). Moreover, this propensity score matching study and three other reports included only a few (five or less) ypT1 patients (23,24,26,27). To our best knowledge, the current study is the first to compare the prognosis of only rectal cancer patients with pathological T1 stage, including 18 ypT1 patients.…”

Section: Discussionmentioning

confidence: 97%

“…However, it remains unclear whether rectal cancer downstaged by preoperative CRT has a different prognosis from that of the same stage without preoperative CRT. Several groups have previously conducted comparative studies of patients with pathological stage I lower rectal cancer according to preoperative CRT, but the conclusions regarding their prognoses were inconsistent (23)(24)(25)(26)(27). Moreover, no similar study confined to pT1 stage has been conducted.…”

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confidence: 99%

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Oncological Outcomes of Pathological T1 Lower Rectal Cancer Patients With or Without Preoperative Chemoradiotherapy

Taira

Nozawa

Kawai

et al. 2020

In Vivo

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Background/Aim: It remains unclear whether rectal cancers down-staged by preoperative chemoradiotherapy (CRT) have similar prognoses to those of the same stage without preoperative CRT. We compared prognoses of pT1 rectal cancer patients stratified by preoperative CRT. Patients and Methods: We retrieved data of patients with pathological T1 rectal cancer between 2003 and 2020. Patients were divided into the "ypT1 group" who received preoperative CRT following surgery and the "pT1 group" who underwent surgery alone. Factors associated with relapse-free survival (RFS) were investigated. Results: Among 86 patients, ypT1 and pT1 groups comprised 18 and 68 patients, respectively. There was no significant difference in RFS between the groups (p=0.19). Tumor location within 5 cm from the anal verge was associated with recurrence (hazard ratio: 0.13, p=0.034). Conclusion: The prognosis of patients with ypT1 rectal cancer was similar to that of patients with pT1. Low tumor location was a poor prognostic factor.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Oncological Outcomes of Pathological T1 Lower Rectal Cancer Patients With or Without Preoperative Chemoradiotherapy

Taira

Nozawa

Kawai

et al. 2020

In Vivo

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“…However, the benefits of chemoradiotherapy for OS and CSS was only found in the groups of T2 stage in our study. Furthermore, some studies demonstrated neoadjuvant chemoradiotherapy prior to surgery could not reduce tumor recurrence in early T-stage lower rectal cancer compared with surgery alone [37,38]. This different result may be contributed to the number of patients and subgroup analysis.…”

Section: Discussionmentioning

confidence: 99%

Is local excision with chemoradiotherapy the optimal treatment for early stage rectal cancer patients？a population-based study

zhu,

Tu,

Pei

et al. 2023

Preprint

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Objective Adjuvant chemoradiotherapy in early stage rectal cancer is still controversial. The purpose of this study was to access the survival benefits of chemoradiotherapy for overall survival (OS) and cancer-specific survival (CSS) in patients with early stage rectal cancer and find the optimal treatment for these patients. Methods The study analyzed data from patients diagnosed with T1-2N0M0 rectal cancer between 2010 and 2016, using the Surveillance, Epidemiology, and End Results (SEER) database. The researchers then divided the patients into low-risk and high-risk groups based on various prognostic factors. Kaplan-Meier analysis was employed to evaluate the impact of chemoradiotherapy on OS and CSS in these patient groups. Results The Kaplan-Meier analysis revealed that patients with T1 stage (T1N0M0) had better OS and CSS outcomes than the T2 stage (T2N0M0) groups. Furthermore, it was shown that both low-risk groups of T1 stage and T2 stage had better OS and CSS outcomes than the high-risk groups. No significant benefits was shown when adding chemoradiotherapy in T1 stage groups while it was observed significant improvements for OS and CSS in T2 stage groups. Furthermore, local excision alone in T1 stage groups and local excision with chemoradiotherapy in T2 stage shown no significant difference comparing to those treated with segmental resection. Conclusion In our study, we found that chemoradiotherapy was beneficial for T2N0M0 rectal cancer patients. What’s more, local excision alone was a feasible alternative for T1N0M0 rectal cancer patients and local excision with chemoradiotherapy was a promising alternative for T2N0M0 rectal cancer patients.

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Prognoses in Pathologically Confirmed T1 Lower Rectal Cancer Patients with or without Preoperative Therapy: An Analysis Using the Surveillance, Epidemiology, and End Results Database

Taira¹,

Nozawa²,

Kawai³

et al. 2021

Oncology

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Introduction Preoperative chemoradiotherapy (CRT) is the standard therapy for downstaging in locally advanced lower rectal cancer. However, it remains unclear whether rectal cancers down-staged by preoperative therapy show similar prognoses to those of the same stage without preoperative therapy. We previously demonstrated that preoperative CRT did not affect prognosis of rectal cancer with pathological T1N0 (pT1N0) stage in a single institute. Here, using a larger dataset, we compared prognoses of (y)pT1 rectal cancer stratified by the use of preoperative therapy and analyzed prognostic factors. Methods Cases of pT1N0 rectal cancer, registered between 2004 and 2016, were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were categorized as the ‘ypT1 group’ if they had undergone preoperative therapy before surgery or as the ‘pT1 group’ if they had undergone surgery alone. overall survival (OS) and cancer-specific survival (CSS) between these groups of patients was compared. Factors associated with CSS and OS were identified by univariate and multivariate analyses. Results Among 3,757 eligible patients, ypT1 and pT1 groups comprised 720 and 3,037 patients, respectively. While ypT1 patients showed poorer CSS than ypT1 patients, there was no significant difference in OS. Preoperative therapy was not an independent prognostic factor for CSS or OS. Multivariate analysis identified age and histological type as significant factors associated with CSS. Sex, age, race, and number of lymph nodes dissected were identified as significant factors associated with OS. Conclusions Prognosis among patients with (y)p T1N0 rectal cancer was similar irrespective of whether they underwent preoperative therapy, which is consistent with our previous observations.

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Oncologic Outcome of ypT1-2N0 Rectal Cancer After Neoadjuvant Chemoradiotherapy Compared With pT1-2N0 Rectal Cancer

Cited by 6 publications

References 24 publications

Oncological Outcomes of Pathological T1 Lower Rectal Cancer Patients With or Without Preoperative Chemoradiotherapy

Oncological Outcomes of Pathological T1 Lower Rectal Cancer Patients With or Without Preoperative Chemoradiotherapy

Is local excision with chemoradiotherapy the optimal treatment for early stage rectal cancer patients？a population-based study

Prognoses in Pathologically Confirmed T1 Lower Rectal Cancer Patients with or without Preoperative Therapy: An Analysis Using the Surveillance, Epidemiology, and End Results Database

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